Elucidation of roles of sphingomyelin in the formation of microvilli
| Project/Area Number |
25711012
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| Research Category |
Grant-in-Aid for Young Scientists (A)
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| Allocation Type | Partial Multi-year Fund |
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| Research Field |
Cell biology
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| Research Institution | Kyushu University |
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Principal Investigator |
Ikenouchi Junicni 九州大学, 理学(系)研究科(研究院), 准教授 (10500051)
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥18,590,000 (Direct Cost: ¥14,300,000、Indirect Cost: ¥4,290,000)
Fiscal Year 2015: ¥5,980,000 (Direct Cost: ¥4,600,000、Indirect Cost: ¥1,380,000)
Fiscal Year 2014: ¥5,980,000 (Direct Cost: ¥4,600,000、Indirect Cost: ¥1,380,000)
Fiscal Year 2013: ¥6,630,000 (Direct Cost: ¥5,100,000、Indirect Cost: ¥1,530,000)
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| Keywords | 微絨毛 / スフィンゴミエリン / ブレブ / アクチン細胞骨格 / 細胞膜突起構造 / アクチン / 細胞膜突起 / アピカル膜 / 細胞極性 / コレステロール / 上皮細胞 |
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| Outline of Final Research Achievements |
Microvilli are dynamic filamentous-actin-based protrusions of the plasma membrane that are found in the apical membrane of epithelial cells. However, it remains poorly understood how their formation is regulated. The importance of regulators of actin cytoskeleton in the formation of microvilli had been revealed in the previous studies; however,the contribution of membrane lipids in the formation of microvilli has been largely underestimated.In this research project, we found that sphingomyelin clustering underlies the formation of microvilli. Furthermore, we clarified how sphingomyelin cluster regulates actin cytoskeleton in the formation of microvilli. We also examined the molecular mechanisms of membrane bleb, which is another protrusion of plasma membrane.
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Report
(4 results)
Research Products
(17 results)
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[Journal Article] EPLIN is a crucial regulator for extrusion of RasV12-transformed cells.2015
Author(s)
Ohoka, A., Kajita, M., Ikenouchi, J., Yako, Y., Kitamoto, S., Kon, S., Ikegawa, M., Shimada, T., Ishikawa, S., and Fujita, Y.
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Journal Title
Journal of Cell Science
Volume: 128
Pages: 781-789
DOI
Related Report
Peer Reviewed / Acknowledgement Compliant
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