| Budget Amount *help |
¥18,590,000 (Direct Cost: ¥14,300,000、Indirect Cost: ¥4,290,000)
Fiscal Year 2015: ¥5,980,000 (Direct Cost: ¥4,600,000、Indirect Cost: ¥1,380,000)
Fiscal Year 2014: ¥5,980,000 (Direct Cost: ¥4,600,000、Indirect Cost: ¥1,380,000)
Fiscal Year 2013: ¥6,630,000 (Direct Cost: ¥5,100,000、Indirect Cost: ¥1,530,000)
|
|---|
| Outline of Final Research Achievements |
Microvilli are dynamic filamentous-actin-based protrusions of the plasma membrane that are found in the apical membrane of epithelial cells. However, it remains poorly understood how their formation is regulated. The importance of regulators of actin cytoskeleton in the formation of microvilli had been revealed in the previous studies; however,the contribution of membrane lipids in the formation of microvilli has been largely underestimated.In this research project, we found that sphingomyelin clustering underlies the formation of microvilli. Furthermore, we clarified how sphingomyelin cluster regulates actin cytoskeleton in the formation of microvilli. We also examined the molecular mechanisms of membrane bleb, which is another protrusion of plasma membrane.
|
