A molecular mechanism underlying cell orientation relative to global directional cues
| Project/Area Number |
25711013
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| Research Category |
Grant-in-Aid for Young Scientists (A)
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| Allocation Type | Partial Multi-year Fund |
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| Research Field |
Developmental biology
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| Research Institution | Akita University |
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Principal Investigator |
Yamazaki Masakazu 秋田大学, 医学(系)研究科(研究院), 准教授 (40373378)
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥26,650,000 (Direct Cost: ¥20,500,000、Indirect Cost: ¥6,150,000)
Fiscal Year 2015: ¥8,580,000 (Direct Cost: ¥6,600,000、Indirect Cost: ¥1,980,000)
Fiscal Year 2014: ¥8,580,000 (Direct Cost: ¥6,600,000、Indirect Cost: ¥1,980,000)
Fiscal Year 2013: ¥9,490,000 (Direct Cost: ¥7,300,000、Indirect Cost: ¥2,190,000)
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| Keywords | 発生・分化 / 細胞・組織 / 遺伝学 / 平面内細胞極性 / PCP |
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| Outline of Final Research Achievements |
In Drosophila, planar cell polarity (PCP) molecules such as Dachsous (Ds) are thought to function as global directional cues orienting cellular asymmetry, which is manifested as polarized localization of PCP core proteins such as Frizzled (Fz). However, the relationship between the Ds gradient and Fz asymmetry in the eye is opposite to that in the wing, thereby causing controversy about how these two systems are connected. Here, using a combination of experiment and computer simulation, we elucidated a mechanism by which the Pk:Sple ratio determines the orientation of the core proteins relative to the Ds gradient.
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Report
(4 results)
Research Products
(32 results)
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[Presentation] 平面内細胞極性の数理モデル2016
Author(s)
秋山正和（発表者）, 鮎川 友紀, 山崎正和
Organizer
基生研研究会「物理学は生物現象の謎を解けるか」
Place of Presentation
基礎生物学研究所
Year and Date
2016-01-05
Related Report
Invited
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[Presentation] A Mathematical Model of Planar Cell Polality2014
Author(s)
Masakazu Akiyama（発表者）, Tomonori Ayukawa, Masakazu Yamazaki
Organizer
The 2nd Slovak-Japan Conference on Applied Mathematics in the South-Central Slovakia Gemer
Place of Presentation
Slovakia
Year and Date
2014-09-14 – 2014-09-18
Related Report
Invited
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[Presentation] 平面内細胞極性の分子機構に関する研究2014
Author(s)
山崎正和（発表者）, 鮎川友紀, 秋山正和, 佐々木雄彦, 妹尾春樹
Organizer
日本解剖学会第60回東北・北海道連合支部学術集会
Place of Presentation
福島
Year and Date
2014-09-06 – 2014-09-07
Related Report
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