| Budget Amount *help |
¥26,650,000 (Direct Cost: ¥20,500,000、Indirect Cost: ¥6,150,000)
Fiscal Year 2015: ¥8,580,000 (Direct Cost: ¥6,600,000、Indirect Cost: ¥1,980,000)
Fiscal Year 2014: ¥8,580,000 (Direct Cost: ¥6,600,000、Indirect Cost: ¥1,980,000)
Fiscal Year 2013: ¥9,490,000 (Direct Cost: ¥7,300,000、Indirect Cost: ¥2,190,000)
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| Outline of Final Research Achievements |
In Drosophila, planar cell polarity (PCP) molecules such as Dachsous (Ds) are thought to function as global directional cues orienting cellular asymmetry, which is manifested as polarized localization of PCP core proteins such as Frizzled (Fz). However, the relationship between the Ds gradient and Fz asymmetry in the eye is opposite to that in the wing, thereby causing controversy about how these two systems are connected. Here, using a combination of experiment and computer simulation, we elucidated a mechanism by which the Pk:Sple ratio determines the orientation of the core proteins relative to the Ds gradient.
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