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Molecular evolutionary processes of dosage compensation based on the comparisons of closely-related species in Drosophila

Research Project

Project/Area Number 25711023
Research Category

Grant-in-Aid for Young Scientists (A)

Allocation TypePartial Multi-year Fund
Research Field Evolutionary biology
Research InstitutionTokyo Metropolitan University (2016-2017)
National Institute of Genetics (2013-2015)

Principal Investigator

Nozawa Masafumi  首都大学東京, 理工学研究科, 助教 (50623534)

Project Period (FY) 2013-04-01 – 2018-03-31
Project Status Completed (Fiscal Year 2017)
Budget Amount *help
¥26,390,000 (Direct Cost: ¥20,300,000、Indirect Cost: ¥6,090,000)
Fiscal Year 2016: ¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2015: ¥5,590,000 (Direct Cost: ¥4,300,000、Indirect Cost: ¥1,290,000)
Fiscal Year 2014: ¥7,280,000 (Direct Cost: ¥5,600,000、Indirect Cost: ¥1,680,000)
Fiscal Year 2013: ¥9,100,000 (Direct Cost: ¥7,000,000、Indirect Cost: ¥2,100,000)
Keywords性染色体 / ショウジョウバエ / 遺伝子量補償 / 遺伝子発現 / ゲノム / トランスクリプトーム / 偽遺伝子化 / 進化 / 遺伝学 / 遺伝子 / 昆虫 / 抗体
Outline of Final Research Achievements

When sex chromosomes emerge from a pair of autosomes, the Y chromosomes highly degenerate due to recombination suppression in many cases. To overcome this potential disadvantage, many organisms acquire the so-called dosage compensation by which X-linked genes in males are upregulated to compensate the decrease of gene dosage due to the loss of Y-linked homologs. However, how dosage compensation evolves at the molecular level largely remains unknown.
To tackle this question, I have focused on Drosophila miranda that acquired the sex chromosomes around 1 million years ago. Comparing the genomes and transcriptomes of D. miranda and its closely-related species without young sex chromosomes, I found that not only Y but also X degenerate in the early stage of sex chromosome evolution. I also found that dosage compensation operates on each gene at the initial evolutionary stage (i.e., gene-by-gene dosage compensation).

Report

(6 results)
  • 2017 Annual Research Report   Final Research Report ( PDF )
  • 2016 Annual Research Report
  • 2015 Annual Research Report
  • 2014 Annual Research Report
  • 2013 Annual Research Report
  • Research Products

    (26 results)

All 2018 2017 2016 2015 2014 2013 Other

All Journal Article (4 results) (of which Int'l Joint Research: 2 results,  Peer Reviewed: 4 results,  Open Access: 2 results,  Acknowledgement Compliant: 3 results) Presentation (21 results) (of which Int'l Joint Research: 3 results,  Invited: 13 results) Remarks (1 results)

  • [Journal Article] Accelerated pseudogenization on the neo-X chroosome in Drosophila miranda2016

    • Author(s)
      Nozawa M, Onizuka K, Fujimi M, Ikeo K, and Gojobori T
    • Journal Title

      Nature Communications

      Volume: 7 Issue: 1 Pages: 13659-13659

    • DOI

      10.1038/ncomms13659

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Evolutionary transitions of microRNA-target pairs2016

    • Author(s)
      Nozawa M, Fujimi M, Iwamoto C, Fukuda N, Ikeo K, and Gojobori T
    • Journal Title

      Genome Biology and Evolution

      Volume: 8 Issue: 5 Pages: 1621-1633

    • DOI

      10.1093/gbe/evw092

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Origin and evolution of noncoding RNAs2016

    • Author(s)
      Nozawa M and Kinjo S
    • Journal Title

      Encyclopedia of Evolutionary Biology

      Volume: 3 Pages: 130-135

    • DOI

      10.1016/b978-0-12-800049-6.00181-5

    • ISBN
      9780128004265
    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Tissue- and stage-dependent dosage compensation on the neo-X chromosome in Drosophila pseudoobscura2014

    • Author(s)
      Masafumi NOZAWA, Nana FUKUDA, Kazuho IKEO, and Takashi GOJOBORI
    • Journal Title

      Molecular Biology and Evolution

      Volume: 31 Issue: 3 Pages: 614-624

    • DOI

      10.1093/molbev/mst239

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Presentation] How have sex chromosomes become a major sex-determination system in spite of their potential disadvantage?2018

    • Author(s)
      Nozawa M
    • Organizer
      2017 UOS-TMU Joint Conference
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] 性染色体はY染色体だけでなくX染色体の退化も引き起こす?:ショウジョウバエNeo性染色体を用いた検証2017

    • Author(s)
      野澤昌文
    • Organizer
      性と生殖の懇談会
    • Place of Presentation
      名古屋大学
    • Year and Date
      2017-01-24
    • Related Report
      2016 Annual Research Report
    • Invited
  • [Presentation] ショウジョウバエにおけるNeo性染色体の進化:性染色体化は有害か?2017

    • Author(s)
      野澤昌文
    • Organizer
      ConBio2017・多細胞動物における性決定システムの多様性と進化
    • Related Report
      2017 Annual Research Report
    • Invited
  • [Presentation] ショウジョウバエゲノムと遺伝学で性染色体の進化をどこまで理解できるか?2017

    • Author(s)
      野澤昌文
    • Organizer
      遺伝研研究集会・進化遺伝学における実験的研究と理論的研究の融合
    • Related Report
      2017 Annual Research Report
    • Invited
  • [Presentation] Accelerated pseudogenization on the neo-X chromosome in Drosophila miranda2017

    • Author(s)
      Nozawa M
    • Organizer
      SMBE satellite meeting on Molecular Evolution and Medicine
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] ミランダショウジョウバエにおけるNeo-X染色体の退化2017

    • Author(s)
      野澤昌文
    • Organizer
      第19回日本進化学会
    • Related Report
      2017 Annual Research Report
  • [Presentation] Not only the neo-Y chromosome but also the neo-X chromosome is under accelerated pseudogenization in Drosophila miranda2017

    • Author(s)
      Nozawa M
    • Organizer
      The 2017 SMBE conference
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 性染色体の進化:なぜ多くの生物が性染色体を持つのか?2016

    • Author(s)
      野澤昌文
    • Organizer
      第88回日本遺伝学会
    • Place of Presentation
      日本大学三島キャンパス
    • Year and Date
      2016-09-07
    • Related Report
      2016 Annual Research Report
    • Invited
  • [Presentation] 性染色体の退化過程の解明:ORFの破損?それとも転写の停止?2016

    • Author(s)
      野澤昌文
    • Organizer
      第18回日本進化学会
    • Place of Presentation
      東京工業大学大岡山キャンパス
    • Year and Date
      2016-08-25
    • Related Report
      2016 Annual Research Report
  • [Presentation] 性染色体と性的拮抗の進化2016

    • Author(s)
      野澤昌文
    • Organizer
      遺伝研研究集会・分子進化学の現状と今後の展望
    • Place of Presentation
      国立遺伝学研究所
    • Year and Date
      2016-08-20
    • Related Report
      2016 Annual Research Report
    • Invited
  • [Presentation] ショウジョウバエにおける性染色体の進化:性染色体は進化の袋小路か?2015

    • Author(s)
      野澤昌文
    • Organizer
      首都大学東京生命科学コース教室セミナー
    • Place of Presentation
      首都大学東京(八王子)
    • Year and Date
      2015-11-11
    • Related Report
      2015 Annual Research Report
  • [Presentation] メス化およびオス化がショウジョウバエNeo性染色体の偽遺伝子化を促進する2015

    • Author(s)
      野澤昌文
    • Organizer
      日本遺伝学会
    • Place of Presentation
      東北大学(仙台)
    • Year and Date
      2015-09-24
    • Related Report
      2015 Annual Research Report
  • [Presentation] ショウジョウバエにおける遺伝子量補償の進化-異型性染色体の進化過程解明を目指して-2015

    • Author(s)
      野澤昌文
    • Organizer
      遺伝研研究集会・ビッグデータ時代の分子進化
    • Place of Presentation
      国立遺伝学研究所(三島)
    • Year and Date
      2015-06-27
    • Related Report
      2015 Annual Research Report
  • [Presentation] 遺伝子発現からみる表現型進化2015

    • Author(s)
      野澤昌文
    • Organizer
      バイオサイエンス教育研究センター・セミナー
    • Place of Presentation
      宇都宮大学(栃木県宇都宮市)
    • Year and Date
      2015-03-26
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] 遺伝子量補償機構の分子進化2014

    • Author(s)
      野澤昌文
    • Organizer
      遺伝研シンポジウム・木村資生博士生誕90周年記念シンポジウム
    • Place of Presentation
      国立遺伝学研究所(静岡県三島市)
    • Year and Date
      2014-11-13 – 2014-11-14
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] ショウジョウバエ種間比較から探る遺伝子量補償機構の進化2014

    • Author(s)
      野澤昌文
    • Organizer
      日本遺伝学会第86回大会
    • Place of Presentation
      長浜バイオ大学(滋賀県長浜市)
    • Year and Date
      2014-09-17 – 2014-09-19
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] Tissue- and stage-dependent dosage compensation on the neo-X chromosome in Drosophila pseudoobscura2014

    • Author(s)
      Masafumi NOZAWA
    • Organizer
      SMBE Satellite Meeting/NIG International Symposium: The Causes of Genome Evolution
    • Place of Presentation
      Toray Conference Center (Mishima, Japan)
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] Re-evaluation of dosage compensation in Drosophila species2013

    • Author(s)
      Masafumi NOZAWA
    • Organizer
      Society for Molecular Biology and Evolution
    • Place of Presentation
      Hyatt Regency Chicago (Chiago, USA)
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] ショウジョウバエにおける遺伝子量補償機構の進化2013

    • Author(s)
      野澤 昌文
    • Organizer
      国立遺伝学研究所研究集会「新機能獲得の分子進化」
    • Place of Presentation
      国立遺伝学研究所(静岡県三島市)
    • Related Report
      2013 Annual Research Report
  • [Presentation] ショウジョウバエの種間比較から遺伝子量補償機構を明らかにする2013

    • Author(s)
      野澤 昌文
    • Organizer
      日本進化学会第15回大会
    • Place of Presentation
      筑波大学(茨城県つくば市)
    • Related Report
      2013 Annual Research Report
  • [Presentation] 種間比較から遺伝子量補償機構の進化を探る2013

    • Author(s)
      野澤 昌文
    • Organizer
      第42回東北大学インシリコ-メガバンク研究会
    • Place of Presentation
      東北大学(宮城県仙台市)
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Remarks] 首都大学東京生命科学コース進化遺伝学研究室

    • URL

      http://www.biol.se.tmu.ac.jp/labo.asp?ID=evogen

    • Related Report
      2016 Annual Research Report

URL: 

Published: 2013-05-21   Modified: 2019-07-29  

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