| Budget Amount *help |
¥27,040,000 (Direct Cost: ¥20,800,000、Indirect Cost: ¥6,240,000)
Fiscal Year 2015: ¥6,370,000 (Direct Cost: ¥4,900,000、Indirect Cost: ¥1,470,000)
Fiscal Year 2014: ¥6,370,000 (Direct Cost: ¥4,900,000、Indirect Cost: ¥1,470,000)
Fiscal Year 2013: ¥14,300,000 (Direct Cost: ¥11,000,000、Indirect Cost: ¥3,300,000)
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| Outline of Final Research Achievements |
Rapid growth in high-throughput genomic biology opens new directions for studies focusing on human evolution and search for the molecular basis of human uniqueness. One of such direction is neurogenomics, a discipline bordering functional genomics and neuroscience. Neurogenomics aims to uncover how the genome contributes to the structure and function of the nervous system. Here we investigated transcriptome features distinguishing human brain regions from those of non-human apes by using eight distinct brain regions. The results show extensive transcriptome divergence among species in all brain regions, as well as excess of human-specific transcriptome changes in all brain regions except hippocampus. Furthermore, we identified thousands of human-specific expression changes in particular regions, providing candidate genes potentially linked to the unique functions of human brain. Taken together, our analysis provides insights into the evolution of brain region functionality to humans.
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