Elucidation of the mechanisms of growth stimulation of lactic acid bacteria by neurotransmitter and proposal for the novel concept of neurobiotics
| Project/Area Number |
25712032
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| Research Category |
Grant-in-Aid for Young Scientists (A)
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| Allocation Type | Partial Multi-year Fund |
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| Research Field |
Animal production science
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| Research Institution | National Agriculture and Food Research Organization |
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Principal Investigator |
Tohno Masanori 国立研究開発法人農業・食品産業技術総合研究機構, 畜産研究部門・飼養管理技術研究領域, 主任研究員 (50547718)
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥24,960,000 (Direct Cost: ¥19,200,000、Indirect Cost: ¥5,760,000)
Fiscal Year 2015: ¥7,410,000 (Direct Cost: ¥5,700,000、Indirect Cost: ¥1,710,000)
Fiscal Year 2014: ¥6,890,000 (Direct Cost: ¥5,300,000、Indirect Cost: ¥1,590,000)
Fiscal Year 2013: ¥10,660,000 (Direct Cost: ¥8,200,000、Indirect Cost: ¥2,460,000)
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| Keywords | 微生物 / 畜産学 / 乳酸菌 / ゲノム |
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| Outline of Final Research Achievements |
The aim of this study is to elucidate the mechanisms of growth stimulation of lactic acid bacteria by neurotransmitter, namely neurobiotics. The genome DNA of neurobiotics belonging to the genus Lactobacillus species, such as Lactobacillus hokkaidonensis, L. plantarum and L. buchneri contains several genes associated with the bacterial two-component systems. After feeding with a diet including certain neurobiotics for cows, rumen samples were collected and applied to the metagenomic analysis based on bacterial 16S rRNA genes. Metagenomic data from rumen samples clearly showed that the genus Lactobacillus was detected only in the rumen samples from cows with a necrobiotic diet, and that the copy numbers of 16S rRNA genes were significantly increased in the samples. This could contribute to the production of new functional foods and feeds with useful abilities such as maintenance of intestinal microflora.
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Report
(5 results)
Research Products
(9 results)
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[Journal Article] Aerococcus vaginalis sp. nov., isolated from the vaginal mucosa of a beef cow, and emended descriptions of Aerococcus suis, Aerococcus viridans, Aerococcus urinaeequi, Aerococcus urinaehominis, Aerococcus urinae, Aerococcus christensenii and Aerococcus sanguinicol2014
Author(s)
Tohno M, Kitahara M, Matsuyama S, Kimura K, Ohkuma M, Tajima K
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Journal Title
International Journal of Systematic and Evolutionary Microbiology
Volume: 64
Issue: Pt_4
Pages: 1229-1236
DOI
Related Report
Peer Reviewed / Open Access
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