| Budget Amount *help |
¥24,310,000 (Direct Cost: ¥18,700,000、Indirect Cost: ¥5,610,000)
Fiscal Year 2016: ¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2015: ¥6,370,000 (Direct Cost: ¥4,900,000、Indirect Cost: ¥1,470,000)
Fiscal Year 2014: ¥6,370,000 (Direct Cost: ¥4,900,000、Indirect Cost: ¥1,470,000)
Fiscal Year 2013: ¥6,890,000 (Direct Cost: ¥5,300,000、Indirect Cost: ¥1,590,000)
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| Outline of Final Research Achievements |
To elucidate roles of GARP complex during mammalian development, we obtained previously established mutant mouse lines for components of the GARP complex and generated knockout mouse lines for genes that we newly identified as components of the GARP complex. From phenotypes of mutant embryos, we found that these genes could be classified into three groups. These results suggest that the GARP complex plays various roles by exchanging components during mammalian development. Furthermore, we carried out liver specific Vps52 knockout analysis for a model for identification of the role of the GARP complex during tissue development. Liver specific Vps52 knockout embryos showed very similar phenotypes to liver specific knockout embryos for an autophagy related gene. These results provide new evidence that the GARP complex seems to regulate autophagy.
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