| Budget Amount *help |
¥24,570,000 (Direct Cost: ¥18,900,000、Indirect Cost: ¥5,670,000)
Fiscal Year 2016: ¥6,500,000 (Direct Cost: ¥5,000,000、Indirect Cost: ¥1,500,000)
Fiscal Year 2015: ¥6,370,000 (Direct Cost: ¥4,900,000、Indirect Cost: ¥1,470,000)
Fiscal Year 2014: ¥6,110,000 (Direct Cost: ¥4,700,000、Indirect Cost: ¥1,410,000)
Fiscal Year 2013: ¥5,590,000 (Direct Cost: ¥4,300,000、Indirect Cost: ¥1,290,000)
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| Outline of Final Research Achievements |
Infertility is now a major human issue worldwide and one-sixth of couples use infertility clinics in Japan. Although more than 1 in 30 babies have now been born using assisted reproductive technologies (ARTs) such as in vitro fertilization, unfortunately, the success rates of ARTs have reduced gradually to about 10 to 20%. One of the main reasons of the poor quality of oocytes and early embryos is chromosome abnormality, most probably caused by advanced maternal age and environmental stresses. Therefore, to increase the pregnancy rate and ensure safe births, assessing embryo quality, particularly focusing on chromosome integrity, before implantation is essential. In this study, we have developed a live-cell imaging methodology that enables us to quantify various events taking place continuously from fertilization to the blastocyst stage, including chromosome segregation during cleavages in various mammalian embryos.
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