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Functional analysis of stem cell glycans and development of novel glycan engineering technologies for regenerative medicine

Research Project

Project/Area Number 25712039
Research Category

Grant-in-Aid for Young Scientists (A)

Allocation TypePartial Multi-year Fund
Research Field Applied molecular and cellular biology
Research InstitutionNational Institute of Advanced Industrial Science and Technology

Principal Investigator

Tateno Hiroaki  国立研究開発法人産業技術総合研究所, 創薬基盤研究部門, 主任研究員 (30450670)

Project Period (FY) 2013-04-01 – 2016-03-31
Project Status Completed (Fiscal Year 2015)
Budget Amount *help
¥24,700,000 (Direct Cost: ¥19,000,000、Indirect Cost: ¥5,700,000)
Fiscal Year 2015: ¥7,930,000 (Direct Cost: ¥6,100,000、Indirect Cost: ¥1,830,000)
Fiscal Year 2014: ¥7,930,000 (Direct Cost: ¥6,100,000、Indirect Cost: ¥1,830,000)
Fiscal Year 2013: ¥8,840,000 (Direct Cost: ¥6,800,000、Indirect Cost: ¥2,040,000)
Keywords糖鎖 / レクチン / 幹細胞 / 再生医療 / 腫瘍
Outline of Final Research Achievements

hiPSCs and hESCs have abilities to proliferate eternally (self-renewal) and differentiate into any cell types such as cardiomyocytes and neurons (pluripotency). Therefore, hiPSCs and hESCs gain a lot of attentions as cell sources for regenerative medicine. I have discovered a hiPSC/hESC-specific lectin called rBC2LCN. In this study, I analyzed the binding mechanisms of rBC2LCN to hiPSCs/hESCs, clarified the functions of glycans recognized by the lectin, and developed technologies to detect and eliminate undifferentiated cells.

Report

(4 results)
  • 2015 Annual Research Report   Final Research Report ( PDF )
  • 2014 Annual Research Report
  • 2013 Annual Research Report
  • Research Products

    (60 results)

All 2016 2015 2014 2013 Other

All Journal Article (30 results) (of which Peer Reviewed: 20 results,  Open Access: 8 results,  Acknowledgement Compliant: 3 results) Presentation (21 results) (of which Int'l Joint Research: 3 results,  Invited: 9 results) Book (5 results) Remarks (3 results) Patent(Industrial Property Rights) (1 results)

  • [Journal Article] Cell surface localization of importin α1/KPNA2 affects cancer cell proliferation by regulating FGF1 signalling.2016

    • Author(s)
      Yamada K., Miyamoto Y., Tsujii A., Moriyama T., Ikuno Y., Shiromizu T., Serada S., Fujimoto M., Tomonaga T., Naka T., Oka M.
    • Journal Title

      Sci Rep

      Volume: 6 Issue: 1 Pages: 24823-24823

    • DOI

      10.1038/srep24823

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Mutated leguminous lectin containing a heparin-binding like motif in a carbohydrate-binding loop specifically binds to heparin2015

    • Author(s)
      Abo, H. , Soga, K., Tanaka, A., Tateno, H., Hirabayashi, J., Yamamoto, K
    • Journal Title

      PLoS One

      Volume: 10 Issue: 12 Pages: 1-13

    • DOI

      10.1371/journal.pone.0145834

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Mammalian Cell Surface Display as a Novel Method for Developing Engineered Lectins with Novel Characteristics.2015

    • Author(s)
      Soga K, Abo H, Qin SY, Kyoutou T, Hiemori K, Tateno H, Matsumoto N, Hirabayashi J, Yamamoto K
    • Journal Title

      Biomolecules

      Volume: 5 Issue: 3 Pages: 1540-1562

    • DOI

      10.3390/biom5031540

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Effects of Hemagglutination Activity in the Serum of a Deep-Sea Vent Endemic Crab, <i>Shinkaia Crosnieri</i>, on Non-Symbiotic and Symbiotic Bacteria2015

    • Author(s)
      So Fujiyoshi, Hiroaki Tateno, Tomoo Watsuji, Hideyuki Yamaguchi, Daisuke Fukushima, Sayaka Mino, Makoto Sugimura, Tomoo Sawabe, Ken Takai, Shigeki Sawayama, Satoshi Nakagawa
    • Journal Title

      Microbes and Environments

      Volume: 30 Issue: 3 Pages: 228-234

    • DOI

      10.1264/jsme2.ME15066

    • NAID

      130005099200

    • ISSN
      1342-6311, 1347-4405
    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Lectin Engineering, a Molecular Evolutionary Approach to Expanding the Lectin Utilities2015

    • Author(s)
      Hu D, Tateno H, Hirabayashi J
    • Journal Title

      Molecules

      Volume: 20 Issue: 5 Pages: 7637-7656

    • DOI

      10.3390/molecules20057637

    • Related Report
      2015 Annual Research Report 2014 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] A Novel Probe as Surface Glycan Marker of Pluripotent Stem Cells: Research Outcomes and Application to Regenerative Medicine.2015

    • Author(s)
      Hirabayashi J, Tateno H, Onuma Y, Ito Y
    • Journal Title

      Adv Healthc Mater.

      Volume: なし Issue: 16 Pages: 2520-2529

    • DOI

      10.1002/adhm.201400837

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Mannose-recognition mutant of the galactose/N-acetylgalactosamine-specific C-type lectin CEL-I engineered by site-directed mutagenesis2015

    • Author(s)
      Moriuchi H, Unno H, Goda S, Tateno H, Hirabayashi J, Hatakeyama T
    • Journal Title

      Biochim Biophys Acta

      Volume: 1850 Issue: 7 Pages: 1457-1465

    • DOI

      10.1016/j.bbagen.2015.04.004

    • Related Report
      2015 Annual Research Report 2014 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Elimination of tumorigenic human pluripotent stem cells by a recombinant lectin-toxin fusion protein2015

    • Author(s)
      Tateno H, Onuma Y, Ito Y, Minoshima F, Saito S, Shimizu M, Aiki Y, Asashima M, Hirabayashi J
    • Journal Title

      Stem Cell Reports

      Volume: 4 Issue: 5 Pages: 811

    • DOI

      10.1016/j.stemcr.2015.02.016

    • URL

      https://pure.teikyo.jp/en/publications/82cd5f23-0e97-4770-9612-8e4b9ebff79c

    • Related Report
      2015 Annual Research Report 2014 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Development and Applications of the Lectin Microarray2015

    • Author(s)
      Hirabayashi J, Kuno A, Tateno H
    • Journal Title

      Top Curr Chem

      Volume: 367 Pages: 105-124

    • DOI

      10.1007/128_2014_612

    • ISBN
      9783319213163, 9783319213170
    • Related Report
      2015 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Engineering of a 3'-sulpho-Galβ1-4GlcNAc-specific probe by a single amino acid substitution of a fungal galectin2015

    • Author(s)
      Hu D, Huang H, Tateno H, Nakakita S, Sato T, Narimatsu H, Yao X, Hirabayashi J
    • Journal Title

      J Biochem

      Volume: 157 Issue: 4 Pages: 197-200

    • DOI

      10.1093/jb/mvv023

    • Related Report
      2015 Annual Research Report 2014 Annual Research Report
    • Peer Reviewed
  • [Journal Article] S-nitrosylation of mouse galectin-2 prevents oxidative inactivation by hydrogen peroxide2015

    • Author(s)
      Tamura M, Saito M, Yamamoto K, Takeuchi T, Ohtake K, Tateno H, Hirabayashi J, Kobayashi J, Arata Y
    • Journal Title

      Biochem Biophys Res Commun

      Volume: 457 Issue: 4 Pages: 712

    • DOI

      10.1016/j.bbrc.2015.01.055

    • NAID

      120005575972

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Isolation and Biochemical Characterization of Apios Tuber Lectin2015

    • Author(s)
      Eri Kenmochi, Syed Rashel Kabir, Tomohisa Ogawa, Ryno Naude, Hiroaki Tateno, Jun Hirabayashi and Koji Muramoto
    • Journal Title

      Molecules

      Volume: 20 Issue: 1 Pages: 987-1002

    • DOI

      10.3390/molecules20010987

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] The Lectin Frontier Database (LfDB), and data generation based on frontal affinity chromatography2015

    • Author(s)
      Hirabayashi J, Tateno H, Shikanai T, Aoki-Kinoshita KF, Narimatsu H
    • Journal Title

      Molecules

      Volume: 20 Issue: 1 Pages: 951-973

    • DOI

      10.3390/molecules20010951

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] A C-type lectin isolated from the skin of Japanese bullhead shark (Heterodontus japonicus) binds a remarkably broad range of sugars and induces blood coagulation2015

    • Author(s)
      Tsutsui S, Dotsuta Y, Ono A, Suzuki M, Tateno H, Hirabayashi J, Nakamura O
    • Journal Title

      J Biochem

      Volume: 157 Issue: 5 Pages: 345-356

    • DOI

      10.1093/jb/mvu080

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Molecular clock regulates daily α1-2-fucosylation of the neural cell adhesion molecule (NCAM) within mouse secondary olfactory neurons2014

    • Author(s)
      Kondoh D, Tateno H, Hirabayashi J, Yasumoto Y, Nakao R, Oishi K
    • Journal Title

      J Biol Chem

      Volume: 289 Issue: 12 Pages: 36158-36165

    • DOI

      10.1080/09168451.2014.948376

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Lectin structures: classification based on the 3-D structures2014

    • Author(s)
      Fujimoto Z, Tateno H, Hirabayashi J
    • Journal Title

      Methods Mol Biol

      Volume: 1200 Pages: 579-606

    • DOI

      10.1007/978-1-4939-1292-6_46

    • ISBN
      9781493912919, 9781493912926
    • Related Report
      2014 Annual Research Report
  • [Journal Article] Comprehensive list of lectins: origins, natures, and carbohydrate specificities2014

    • Author(s)
      Kobayashi, Y, Tateno, H, Ogawa, H, Yamamoto, K, Hirabayashi, J.
    • Journal Title

      Methods Mol. Biol.

      Volume: 1200 Pages: 555-577

    • DOI

      10.1007/978-1-4939-1292-6_45

    • ISBN
      9781493912919, 9781493912926
    • Related Report
      2014 Annual Research Report
  • [Journal Article] Directed evolution of lectins by an improved error-prone PCR and ribosome display method2014

    • Author(s)
      Hu D, Tateno H, Hirabayashi J
    • Journal Title

      Methods Mol Biol

      Volume: 1200 Pages: 527-538

    • DOI

      10.1007/978-1-4939-1292-6_43

    • ISBN
      9781493912919, 9781493912926
    • Related Report
      2014 Annual Research Report
  • [Journal Article] Evaluation of glycan-binding specificity by glycoconjugate microarray with an evanescent-field fluorescence detection system2014

    • Author(s)
      Tateno H
    • Journal Title

      Methods Mol Biol

      Volume: 1200 Pages: 353-359

    • DOI

      10.1007/978-1-4939-1292-6_30

    • ISBN
      9781493912919, 9781493912926
    • Related Report
      2014 Annual Research Report
  • [Journal Article] Live-cell imaging of human pluripotent stem cells by a novel lectin probe rBC2LCN2014

    • Author(s)
      Tateno H, Onuma Y, Ito Y
    • Journal Title

      Methods Mol Biol

      Volume: 1200 Pages: 313-318

    • DOI

      10.1007/978-1-4939-1292-6_26

    • ISBN
      9781493912919, 9781493912926
    • Related Report
      2014 Annual Research Report
  • [Journal Article] Application of lectin microarray to bacteria including Lactobacillus casei/paracasei strains2014

    • Author(s)
      Yasuda E, Sako T, Tateno H, Hirabayashi J
    • Journal Title

      Methods Mol Biol

      Volume: 1200 Pages: 295-311

    • DOI

      10.1007/978-1-4939-1292-6_25

    • ISBN
      9781493912919, 9781493912926
    • Related Report
      2014 Annual Research Report
  • [Journal Article] A medium hyperglycosylated podocalyxin enables noninvasive and quantitative detection of tumorigenic human pluripotent stem cells2014

    • Author(s)
      Tateno H, Onuma Y, Ito Y, Hiemori K, Aiki Y, Shimizu M, Higuchi K, Fukuda M, Warashina M, Honda S, Asashima M, Hirabayashi J.
    • Journal Title

      Scientific Reports

      Volume: 4 Issue: 1 Pages: 4069-4069

    • DOI

      10.1038/srep04069

    • URL

      https://pure.teikyo.jp/en/publications/d022209b-532e-4f84-9920-e62011f45116

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 先端糖鎖プロファイリング技術による新規未分化細胞マーカーの発見とレクチン育種2014

    • Author(s)
      平林淳、舘野浩章
    • Journal Title

      化学と生物

      Volume: 52 Pages: 40-47

    • NAID

      40019936731

    • Related Report
      2013 Annual Research Report
  • [Journal Article] Terminal N-acetylgalactosamine-specific leguminous lectin from Wisteria japonica as a probe for human lung squamous cell carcinoma.2013

    • Author(s)
      Soga et al.
    • Journal Title

      PLoS ONE

      Volume: 8(12) Issue: 12 Pages: e83886-e83886

    • DOI

      10.1371/journal.pone.0083886

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Conformational change of a unique sequence in a fungal galectin from Agrocybe cylindracea controls glycan ligand-binding specificity2013

    • Author(s)
      Kuwabara N, Hu D, Tateno H, Makyio H, Hirabayashi J, Kato R
    • Journal Title

      FEBS Letter

      Volume: 587 Issue: 22 Pages: 3620-3625

    • DOI

      10.1016/j.febslet.2013.08.046

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Tailoring GalNAcα1-3Galβ-specific lectins from a multi-specific fungal galectin: dramatic change of carbohydrate specificity by a single amino-acid substitution2013

    • Author(s)
      Hu D, Tateno H, Sato T, Narimatsu H, Hirabayashi J
    • Journal Title

      Biochemical Journal

      Volume: 453 Issue: 2 Pages: 261-270

    • DOI

      10.1042/bj20121901

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Podocalyxin is a glycoprotein ligand of the human pluripotent stem cell-specific probe rBC2LCN2013

    • Author(s)
      Tateno H, Matsushima A, Hiemori K, Onuma Y, Ito Y, Hasehira K, Nishimura K,Ohtaka M, Takayasu S, Nakanishi M, Ikehara Y,Nakanishi M, Ohnuma K, Chan T,Toyoda M, Akutsu H, Umezawa A, Asashima M, Hirabayashi J.
    • Journal Title

      Stem Cells Transl Med.

      Volume: 2 Issue: 4 Pages: 265

    • DOI

      10.5966/sctm.2012-0154

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 特異的レクチンを利用したヒト幹細胞の簡便な品質管理法の開発2013

    • Author(s)
      伊藤弓弦、舘野浩章、小沼泰子、平林淳
    • Journal Title

      バイオサイエンスとインダストリー(B&I)

      Volume: 71 Pages: 432-433

    • NAID

      10031192977

    • Related Report
      2013 Annual Research Report
  • [Journal Article] ヒトiPS・ES細胞特異的プローブrBC2LCNの開発2013

    • Author(s)
      舘野浩章
    • Journal Title

      和光純薬時報

      Volume: 81 Pages: 2-3

    • Related Report
      2013 Annual Research Report
  • [Journal Article] The Cellular Glycome of Human Induced Pluripotent Stem Cells and Their Specific Probe rBC2LCN2013

    • Author(s)
      舘野浩章、平林淳
    • Journal Title

      TRENDS IN GLYCOSCIENCE AND GLYCOTECHNOLOGY

      Volume: 26 Pages: 1-35

    • Related Report
      2013 Annual Research Report
  • [Presentation] Detection and elimination of human pluripotent stem cells residing in cell therapy2016

    • Author(s)
      舘野浩章・小沼泰子・伊藤弓弦・浅島誠・平林淳
    • Organizer
      CiRA/ISSCR 2016 International Symposium
    • Place of Presentation
      京都大学
    • Year and Date
      2016-03-22
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 培養液を用いたin vitro造腫瘍性試験の開発2016

    • Author(s)
      舘野浩章
    • Organizer
      第15回日本再生医療学会総会
    • Place of Presentation
      大阪国際会議場
    • Year and Date
      2016-03-19
    • Related Report
      2015 Annual Research Report
    • Invited
  • [Presentation] 薬剤融合型レクチン(rBC2LCN-PE23)によるヒトiPS/ES細胞除去技術の2016

    • Author(s)
      舘野浩章・小沼泰子・伊藤弓弦・浅島誠・平林淳
    • Organizer
      第15回日本再生医療学会総会
    • Place of Presentation
      大阪国際会議場
    • Year and Date
      2016-03-18
    • Related Report
      2015 Annual Research Report
  • [Presentation] 培養液を用いた未分化ヒトiPS細胞の新規定量測定法(GlycoStem法)の開発2016

    • Author(s)
      舘野浩章
    • Organizer
      第2回再生医療産業化展
    • Place of Presentation
      インテックス大阪
    • Year and Date
      2016-02-24
    • Related Report
      2015 Annual Research Report
    • Invited
  • [Presentation] 細胞の品質管理技術の現状と将来2016

    • Author(s)
      舘野浩章
    • Organizer
      平成27年度 先導技術交流会・シンポジウム
    • Place of Presentation
      機械振興会館ホール(地下2階)
    • Year and Date
      2016-01-25
    • Related Report
      2015 Annual Research Report
    • Invited
  • [Presentation] レクチンを用いた幹細胞評価技術の開発と再生医療への実用化2016

    • Author(s)
      舘野浩章
    • Organizer
      かがわ糖質バイオフォーラム「複合糖質・糖鎖研究会」
    • Place of Presentation
      香川県立ミュージアム
    • Year and Date
      2016-01-22
    • Related Report
      2015 Annual Research Report
    • Invited
  • [Presentation] ELIMINATION OF TUMORIGENIC HUMAN PLURIPOTENT STEM CELLS USING A RECOMBINANT LECTIN-TOXIN FUSION PROTEIN2015

    • Author(s)
      舘野浩章・小沼泰子・伊藤弓弦・平林淳
    • Organizer
      23rd International Symposium on Glycoconjugates
    • Place of Presentation
      クロアチア
    • Year and Date
      2015-09-15
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 薬剤融合型レクチンによる腫瘍原生 ヒトiPS/ES細胞除去技術の開発2015

    • Author(s)
      舘野浩章・小沼泰子・伊藤弓弦・浅島誠・平林淳
    • Organizer
      平成 27 年度(第 18 回)日本糖質学会
    • Place of Presentation
      東京大学
    • Year and Date
      2015-07-31
    • Related Report
      2015 Annual Research Report
  • [Presentation] Development and industrial application of lectin-based technologies to detect and eliminate tumorigenic human pluripotent stem cells for safe cell-based therapy2015

    • Author(s)
      舘野浩章・比江森恵子・鈴木加代・小沼泰子・伊藤弓弦・平林淳
    • Organizer
      ISSCR 13th Annual Meeting
    • Place of Presentation
      スウェーデン
    • Year and Date
      2015-06-24
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 培養液を用いた非侵襲的造腫瘍性評価技術(GlycoStem法)の開発2015

    • Author(s)
      舘野浩章、小沼泰子、伊藤弓弦、福田雅和、藁科雅岐、本多進、浅島誠、平林淳
    • Organizer
      第14回日本再生医療学会総会
    • Place of Presentation
      パシフィコ横浜
    • Year and Date
      2015-03-21
    • Related Report
      2014 Annual Research Report
  • [Presentation] Development of a noninvasive and quantitative detection system of tumorigenic human pluripotent stem cells using cell culture supernatants2014

    • Author(s)
      Hiroaki Tateno, Yasuko Onuma, Yuzuru Ito, Masakazu Fukuda, Masaki Warashina, Susumu Honda, Makoto Asashima, Jun Hirabayashi
    • Organizer
      The 5th meeting of Asian Cellular Therapy Organization
    • Place of Presentation
      Hyatt Regency Osaka
    • Year and Date
      2014-11-11
    • Related Report
      2014 Annual Research Report
  • [Presentation] 先端糖鎖プロファイリング技術の開発と再生医療への応用2014

    • Author(s)
      舘野浩章
    • Organizer
      第31回医用高分子研究会講座
    • Place of Presentation
      首都大東京秋葉原サテライトキャンパス 秋葉原ダイビル12階1202室
    • Year and Date
      2014-11-10
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] 先端糖鎖プロファイリング技術の開発と再生医療への応用2014

    • Author(s)
      舘野浩章
    • Organizer
      バイオアナリシス2014
    • Place of Presentation
      東北大学薬学部大講義室
    • Year and Date
      2014-11-08
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] 未分化細胞特異的レクチンBC2LCNの発見と再生医療への応用2014

    • Author(s)
      舘野浩章
    • Organizer
      平成 26 年度(第 17 回)日本糖質学会
    • Place of Presentation
      名古屋大学
    • Year and Date
      2014-08-11
    • Related Report
      2014 Annual Research Report
  • [Presentation] 糖鎖レクチン工学による幹細胞評価 技術の開発と産業展開2014

    • Author(s)
      舘野浩章
    • Organizer
      平成 26 年度(第 17 回)日本糖質学会
    • Place of Presentation
      名古屋大学
    • Year and Date
      2014-08-10
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] レクチンを活用した幹細胞評価技術の開発と産業応用2014

    • Author(s)
      舘野浩章
    • Organizer
      平成26年度第2回つくばイブニングセミナー
    • Place of Presentation
      産総研つくばセンター本部・情報棟1階ネットワーク会議室
    • Year and Date
      2014-07-25
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] 新規未分化細胞特異的プローブ・rBC2LCNの標的分子解明と生細胞イメージングへの応用

    • Author(s)
      舘野浩章、小沼泰子、伊藤弓弦、浅島誠、平林淳
    • Organizer
      第32回日本糖質学会
    • Place of Presentation
      大阪国際交流センター
    • Related Report
      2013 Annual Research Report
  • [Presentation] 高密度レクチンアレイによる新規未分化マーカーrBC2LCNの発見

    • Author(s)
      舘野浩章
    • Organizer
      BIOtech2013
    • Place of Presentation
      東京ビッグサイト
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] DISCOVERY OF A NOVEL PLURIPOTENCY MARKER BC2LCN USING LECTIN MICROARRAY

    • Author(s)
      舘野浩章、小沼泰子、伊藤弓弦、浅島誠、平林淳
    • Organizer
      ISSCR 11th Annual Meeting
    • Place of Presentation
      ボストン
    • Related Report
      2013 Annual Research Report
  • [Presentation] rBC2LCN, a powerful lectin probe for human pluripotent stem cells

    • Author(s)
      小沼泰子、舘野浩章、、平林淳、伊藤弓弦、浅島誠
    • Organizer
      ISSCR 11th Annual Meeting
    • Place of Presentation
      ボストン
    • Related Report
      2013 Annual Research Report
  • [Presentation] ポドカリキシンは新規ヒトiPS/ES細胞特異的プローブrBC2LCNの糖タンパク質リガンドである

    • Author(s)
      舘野浩章、小沼泰子、伊藤弓弦、浅島誠、平林淳
    • Organizer
      第86回日本生化学会
    • Place of Presentation
      パシフィコ横浜
    • Related Report
      2013 Annual Research Report
  • [Book] バイオチップの基礎と応用2015

    • Author(s)
      舘野浩章
    • Total Pages
      274
    • Publisher
      シーエムシー出版
    • Related Report
      2015 Annual Research Report
  • [Book] Topics in Current Chemistry2015

    • Author(s)
      Hirabayashi J, Kuno A, Tateno H
    • Total Pages
      20
    • Publisher
      Springer
    • Related Report
      2014 Annual Research Report
  • [Book] レクチンマイクロアレイによる糖鎖マーカー開発ーがんと多能性幹細胞2014

    • Author(s)
      平林淳、舘野浩章、久野敦
    • Total Pages
      6
    • Publisher
      メディカルビュー社
    • Related Report
      2014 Annual Research Report
  • [Book] Sugar Chains2014

    • Author(s)
      Tateno, H. and Hirabayashi, J.
    • Total Pages
      7
    • Publisher
      Springer Japan
    • Related Report
      2014 Annual Research Report
  • [Book] Glycoscience: Biology and Medicine2014

    • Author(s)
      Tateno, H.
    • Total Pages
      12
    • Publisher
      Springer Japan
    • Related Report
      2014 Annual Research Report
  • [Remarks] 移植用細胞から腫瘍を引き起こすヒトiPS/ES細胞を除く技術を開発

    • URL

      http://www.aist.go.jp/aist_j/press_release/pr2015/pr20150410/pr20150410.html

    • Related Report
      2015 Annual Research Report 2014 Annual Research Report
  • [Remarks] ヒト間葉系幹細胞の分化する能力を評価できる技術を開発

    • URL

      http://www.aist.go.jp/aist_j/press_release/pr2016/pr20160404/pr20160404.html

    • Related Report
      2015 Annual Research Report
  • [Remarks] 再生医療に用いる細胞の安全性を培養液で検査することが可能に

    • URL

      http://www.aist.go.jp/aist_j/new_research/nr20140217/nr20140217.html

    • Related Report
      2013 Annual Research Report
  • [Patent(Industrial Property Rights)] 細胞分化ポテンシャル判別法2014

    • Inventor(s)
      舘野浩章、伊藤弓弦、小沼泰子、平林淳
    • Industrial Property Rights Holder
      舘野浩章、伊藤弓弦、小沼泰子、平林淳
    • Industrial Property Rights Type
      特許
    • Industrial Property Number
      2014-142919
    • Filing Date
      2014-07-11
    • Related Report
      2014 Annual Research Report

URL: 

Published: 2013-05-21   Modified: 2019-07-29  

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