| Budget Amount *help |
¥23,530,000 (Direct Cost: ¥18,100,000、Indirect Cost: ¥5,430,000)
Fiscal Year 2015: ¥7,540,000 (Direct Cost: ¥5,800,000、Indirect Cost: ¥1,740,000)
Fiscal Year 2014: ¥7,540,000 (Direct Cost: ¥5,800,000、Indirect Cost: ¥1,740,000)
Fiscal Year 2013: ¥8,450,000 (Direct Cost: ¥6,500,000、Indirect Cost: ¥1,950,000)
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| Outline of Final Research Achievements |
The scope of soft Lewis acid/hard Bronsted base cooperative catalysis has been substantially expanded. In particular, direct enolization chemistry of 7-azaindoline amides paved the way to produce a variety of enantioenriched aldol and Mannich products with prefect atom economy. The specific activation mode of 7-azaindoline amide is also valid for electrophilic activation of unsaturated amides. In hard Lewis acid/hard Bronsted base cooperative catalysis, Nd/Na heterobimetallic catalyst confined in multi-walled carbon nanotube was implemented in a continuous-flow reaction platform, an ideal form of the industrial synthesis of commodity and speciality chemicals. The Nd/Na catalyst promotes anti-selective nitroaldol reaction to access enantioenriched 1,2-amino alcohols, privileged chiral building blocks for pharmaceuticals, leading to significantly contribution to medicinal chemistry.
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