| Budget Amount *help |
¥24,050,000 (Direct Cost: ¥18,500,000、Indirect Cost: ¥5,550,000)
Fiscal Year 2015: ¥6,110,000 (Direct Cost: ¥4,700,000、Indirect Cost: ¥1,410,000)
Fiscal Year 2014: ¥6,500,000 (Direct Cost: ¥5,000,000、Indirect Cost: ¥1,500,000)
Fiscal Year 2013: ¥11,440,000 (Direct Cost: ¥8,800,000、Indirect Cost: ¥2,640,000)
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| Outline of Final Research Achievements |
After myocardial infarction occurs, many cardiomyocytes receiving blood supply from occluded blood vessels die. However, the molecular mechanisms underlying engulfment of dead cells in myocardial infarction still remain largely unknown. We found that cardiac myofibroblasts that have been known to exert fibrosis engulf the dead cells in myocardial infarction. We also revealed that engulfment by cardiac myofibroblasts depends on MFG-E8.
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