Elucidation of the molecular mechanism of engulfment by cardiac myofibroblast in myocardial infarction
Project/Area Number |
25713007
|
Research Category |
Grant-in-Aid for Young Scientists (A)
|
Allocation Type | Partial Multi-year Fund |
Research Field |
Pharmacology in pharmacy
|
Research Institution | Kyushu University |
Principal Investigator |
Michio Nakaya 九州大学, 薬学研究科(研究院), 准教授 (80464387)
|
Project Period (FY) |
2013-04-01 – 2016-03-31
|
Project Status |
Completed (Fiscal Year 2015)
|
Budget Amount *help |
¥24,050,000 (Direct Cost: ¥18,500,000、Indirect Cost: ¥5,550,000)
Fiscal Year 2015: ¥6,110,000 (Direct Cost: ¥4,700,000、Indirect Cost: ¥1,410,000)
Fiscal Year 2014: ¥6,500,000 (Direct Cost: ¥5,000,000、Indirect Cost: ¥1,500,000)
Fiscal Year 2013: ¥11,440,000 (Direct Cost: ¥8,800,000、Indirect Cost: ¥2,640,000)
|
Keywords | 筋線維芽細胞 / 心筋梗塞 |
Outline of Final Research Achievements |
After myocardial infarction occurs, many cardiomyocytes receiving blood supply from occluded blood vessels die. However, the molecular mechanisms underlying engulfment of dead cells in myocardial infarction still remain largely unknown. We found that cardiac myofibroblasts that have been known to exert fibrosis engulf the dead cells in myocardial infarction. We also revealed that engulfment by cardiac myofibroblasts depends on MFG-E8.
|
Report
(4 results)
Research Products
(22 results)
-
-
[Journal Article] Characterization of Imidazopyridine Compounds as Negative Allosteric Modulators of Proton-Sensing GPR4 in Extracellular Acidification-Induced Responses2015
Author(s)
2. Ayaka Tobo, Masayuki Tobo, Takashi Nakakura, Masashi Ebara, Hideaki Tomura, Chihiro Mogi, Dong-Soon Im, Naoya Murata, Atsushi Kuwabara, Saki Ito, Hayato Fukuda, Mitsuhiro Arisawa, Satoshi Shuto, Michio Nakaya, Hitoshi Kurose, Koichi Sato, & Fumikazu Okajima.
-
Journal Title
PLoS ONE
Volume: 10
Pages: e0129334
DOI
Related Report
Peer Reviewed / Open Access
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-