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Observed regular protein aggregation structure and their fate, affecting the fail of our living organism homeostasis

Research Project

Project/Area Number 25713012
Research Category

Grant-in-Aid for Young Scientists (A)

Allocation TypePartial Multi-year Fund
Research Field General medical chemistry
Research InstitutionRyukoku University (2015-2016)
Kyoto University (2013-2014)

Principal Investigator

Yamasaki Masayuki  龍谷大学, 農学部, 准教授 (80397562)

Project Period (FY) 2013-04-01 – 2016-03-31
Project Status Completed (Fiscal Year 2016)
Budget Amount *help
¥24,180,000 (Direct Cost: ¥18,600,000、Indirect Cost: ¥5,580,000)
Fiscal Year 2015: ¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2014: ¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2013: ¥13,910,000 (Direct Cost: ¥10,700,000、Indirect Cost: ¥3,210,000)
Keywordsタンパク質凝集性疾患 / アンチトリプシン / ドメインスワップ / タンパク質の凝集 / 老化とストレス / アンチトリプシン欠損症 / 生体分子医学
Outline of Final Research Achievements

In this study, we evaluate the toxicity of antitrypsin aggregates leading to disease in antitrypsin deficiency, which is represented by its lesion. We here consider the influence on the living body of the formation of an ordered aggregate structure of the causative protein. We examined that antitrypsin aggregates by three kinds of mechanisms and further clarified that its structure changes skillfully with time. Furthermore, due to the fact that they are also secreted out of the cell, abnormality of homeostasis in cells that may take in it was analyzed, but clear observation of cell death etc could not be obtained. Formation of regular aggregates of antitrypsin might be toxic to living organisms

Report

(4 results)
  • 2016 Final Research Report ( PDF )
  • 2015 Annual Research Report
  • 2014 Annual Research Report
  • 2013 Annual Research Report
  • Research Products

    (3 results)

All 2014 Other

All Presentation (2 results) (of which Invited: 1 results) Remarks (1 results)

  • [Presentation] アンチトリプシン凝集体の構造平衡とその毒性評価2014

    • Author(s)
      山崎正幸、小寺里奈、清水瞳
    • Organizer
      第87回日本生化学大会
    • Place of Presentation
      京都
    • Year and Date
      2014-10-17
    • Related Report
      2014 Annual Research Report
  • [Presentation] Serpin polymerizations ; their Structural diversity and Toxicity -2014

    • Author(s)
      Masayuki Yamasaki
    • Organizer
      The 3rd International Conference of Indonesian Chemical Society 2014
    • Place of Presentation
      Ambon, Indonesia
    • Year and Date
      2014-09-16
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Remarks] タンパク質の凝集メカニズムとその疾患の研究

    • URL

      http://www.frontier.kyoto-u.ac.jp/bf01/j/researchMY.html

    • Related Report
      2014 Annual Research Report

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Published: 2013-05-21   Modified: 2019-07-29  

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