| Budget Amount *help |
¥24,180,000 (Direct Cost: ¥18,600,000、Indirect Cost: ¥5,580,000)
Fiscal Year 2015: ¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2014: ¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2013: ¥13,910,000 (Direct Cost: ¥10,700,000、Indirect Cost: ¥3,210,000)
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| Outline of Final Research Achievements |
In this study, we evaluate the toxicity of antitrypsin aggregates leading to disease in antitrypsin deficiency, which is represented by its lesion. We here consider the influence on the living body of the formation of an ordered aggregate structure of the causative protein. We examined that antitrypsin aggregates by three kinds of mechanisms and further clarified that its structure changes skillfully with time. Furthermore, due to the fact that they are also secreted out of the cell, abnormality of homeostasis in cells that may take in it was analyzed, but clear observation of cell death etc could not be obtained. Formation of regular aggregates of antitrypsin might be toxic to living organisms
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