Observed regular protein aggregation structure and their fate, affecting the fail of our living organism homeostasis
Project/Area Number |
25713012
|
Research Category |
Grant-in-Aid for Young Scientists (A)
|
Allocation Type | Partial Multi-year Fund |
Research Field |
General medical chemistry
|
Research Institution | Ryukoku University (2015-2016) Kyoto University (2013-2014) |
Principal Investigator |
|
Project Period (FY) |
2013-04-01 – 2016-03-31
|
Project Status |
Completed (Fiscal Year 2016)
|
Budget Amount *help |
¥24,180,000 (Direct Cost: ¥18,600,000、Indirect Cost: ¥5,580,000)
Fiscal Year 2015: ¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2014: ¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2013: ¥13,910,000 (Direct Cost: ¥10,700,000、Indirect Cost: ¥3,210,000)
|
Keywords | タンパク質凝集性疾患 / アンチトリプシン / ドメインスワップ / タンパク質の凝集 / 老化とストレス / アンチトリプシン欠損症 / 生体分子医学 |
Outline of Final Research Achievements |
In this study, we evaluate the toxicity of antitrypsin aggregates leading to disease in antitrypsin deficiency, which is represented by its lesion. We here consider the influence on the living body of the formation of an ordered aggregate structure of the causative protein. We examined that antitrypsin aggregates by three kinds of mechanisms and further clarified that its structure changes skillfully with time. Furthermore, due to the fact that they are also secreted out of the cell, abnormality of homeostasis in cells that may take in it was analyzed, but clear observation of cell death etc could not be obtained. Formation of regular aggregates of antitrypsin might be toxic to living organisms
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Report
(4 results)
Research Products
(3 results)