Development of PPIs for a histone methyltransferase for leukemia therapy
| Project/Area Number |
25713016
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| Research Category |
Grant-in-Aid for Young Scientists (A)
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| Allocation Type | Partial Multi-year Fund |
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| Research Field |
Experimental pathology
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| Research Institution | The University of Tokyo |
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Principal Investigator |
OKADA YUKI 東京大学, 分子細胞生物学研究所, 准教授 (60546430)
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| Research Collaborator |
SUGA HIROAKI 東京大学, 大学院理学系研究科, 教授 (00361668)
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| Project Period (FY) |
2013-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥19,630,000 (Direct Cost: ¥15,100,000、Indirect Cost: ¥4,530,000)
Fiscal Year 2016: ¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2015: ¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2014: ¥8,450,000 (Direct Cost: ¥6,500,000、Indirect Cost: ¥1,950,000)
Fiscal Year 2013: ¥3,250,000 (Direct Cost: ¥2,500,000、Indirect Cost: ¥750,000)
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| Keywords | エピドラッグ / 白血病 / ペプチドライブラリ / ヒストンメチル化 / トランスレーショナルリサーチ / 癌 / 遺伝子 / エピゲノム / スクリーニング |
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| Outline of Final Research Achievements |
Accumulating evidences have been indicating the involvement of epigenetic dysregulation in various type of diseases, and it accelerates the drug development targeting epigenetic modifiers. Among such modifiers, DOT1L, a histone methyltransferase, has been demonstrated as a promising target for several types of leukemia. In this study, we utilized a peptide library screening system called “RaPID system”, and identified a peptide which inhibits the catalytic activity of DOT1L comparable to an existing commercially-available inhibitor. Thus, our finding not only proposes another inhibitor of DOT1L for leukemia therapy but also suggests peptide libraries for an useful source of epidrugs.
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Report
(5 results)
Research Products
(1 results)
