Molecular basis of mucosal immunity maintained by Th17 cells
| Project/Area Number |
25713019
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| Research Category |
Grant-in-Aid for Young Scientists (A)
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| Allocation Type | Partial Multi-year Fund |
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| Research Field |
Immunology
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| Research Institution | Kyoto University (2015)
Osaka University |
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Principal Investigator |
HIROTA Keiji 京都大学, 再生医科学研究所, 准教授 (90631250)
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥23,530,000 (Direct Cost: ¥18,100,000、Indirect Cost: ¥5,430,000)
Fiscal Year 2015: ¥7,540,000 (Direct Cost: ¥5,800,000、Indirect Cost: ¥1,740,000)
Fiscal Year 2014: ¥7,540,000 (Direct Cost: ¥5,800,000、Indirect Cost: ¥1,740,000)
Fiscal Year 2013: ¥8,450,000 (Direct Cost: ¥6,500,000、Indirect Cost: ¥1,950,000)
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| Keywords | IL-17 / Th17 / 炎症性Tヘルパー細胞 / サイトカイン / 粘膜免疫 |
|---|
| Outline of Final Research Achievements |
Interleukin (IL)-17-producing T helper (Th17) cells play an important role in the maintenance of mucosal immune homeostasis and the host defense against pathogens. In this study, we have established a reporter strain that visualizes IL-17-producing cells and is able to assess their fate. We have studied the regulation and function of Th17 cells and an interaction between Th17 cells and the microbiota in the gut, which controls the constitutive expression of IL-17 and drives production of anti-microbial peptides. We have demonstrated that Th17 cells show plasticity toward T follicular helper cells and help antigen-specific B cells to differentiate into IgA-secreting B cells in the small intestine. Taken together, Th17 cells regulate multiple layers for mucosal immune homeostasis.
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Report
(4 results)
Research Products
(11 results)
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[Journal Article] Detection of T-cell responses to a ubiquitous cellular protein in autoimmune disease.2014
Author(s)
Ito Y, Hashimoto M, Hirota K, Ohkura N, Morikawa H, Nishikawa H, Tanaka A, Furu M, Ito H, Fujii T, Nomura T, Yamazaki S, Morita A, Vignali D, Kappler J, Matsuda S, Mimori T, Sakaguchi N, Sakaguchi S.
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Journal Title
Science
Volume: 346
Issue: 6207
Pages: 363-8
DOI
Related Report
Peer Reviewed
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[Journal Article] Activation of the Aryl Hydrocarbon Receptor Dampens the Severity of Inflammatory Skin Conditions.2014
Author(s)
2)Di Meglio P, Duarte JH, Ahlfors H, Owens ND, Li Y, Villanova F, Tosi I, Hirota K, Nestle FO, Mrowietz U, Gilchrist MJ, Stockinger B.
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Journal Title
Immunity
Volume: 40
Issue: 6
Pages: 989-1001
DOI
Related Report
Peer Reviewed
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