| Budget Amount *help |
¥23,530,000 (Direct Cost: ¥18,100,000、Indirect Cost: ¥5,430,000)
Fiscal Year 2015: ¥7,540,000 (Direct Cost: ¥5,800,000、Indirect Cost: ¥1,740,000)
Fiscal Year 2014: ¥7,540,000 (Direct Cost: ¥5,800,000、Indirect Cost: ¥1,740,000)
Fiscal Year 2013: ¥8,450,000 (Direct Cost: ¥6,500,000、Indirect Cost: ¥1,950,000)
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| Outline of Final Research Achievements |
Interleukin (IL)-17-producing T helper (Th17) cells play an important role in the maintenance of mucosal immune homeostasis and the host defense against pathogens. In this study, we have established a reporter strain that visualizes IL-17-producing cells and is able to assess their fate. We have studied the regulation and function of Th17 cells and an interaction between Th17 cells and the microbiota in the gut, which controls the constitutive expression of IL-17 and drives production of anti-microbial peptides. We have demonstrated that Th17 cells show plasticity toward T follicular helper cells and help antigen-specific B cells to differentiate into IgA-secreting B cells in the small intestine. Taken together, Th17 cells regulate multiple layers for mucosal immune homeostasis.
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