Construction of mass spectrometry based rapid cancer diagnosis system
Project/Area Number |
25713023
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Research Category |
Grant-in-Aid for Young Scientists (A)
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Allocation Type | Partial Multi-year Fund |
Research Field |
Laboratory medicine
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Research Institution | University of Yamanashi |
Principal Investigator |
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Project Period (FY) |
2013-04-01 – 2016-03-31
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Project Status |
Completed (Fiscal Year 2015)
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Budget Amount *help |
¥23,530,000 (Direct Cost: ¥18,100,000、Indirect Cost: ¥5,430,000)
Fiscal Year 2015: ¥7,540,000 (Direct Cost: ¥5,800,000、Indirect Cost: ¥1,740,000)
Fiscal Year 2014: ¥8,580,000 (Direct Cost: ¥6,600,000、Indirect Cost: ¥1,980,000)
Fiscal Year 2013: ¥7,410,000 (Direct Cost: ¥5,700,000、Indirect Cost: ¥1,710,000)
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Keywords | 機械学習 / バルクデータ / がん診断 / 大気圧イオン化法 / リアルタイム質量分析 / メタボロミクス / 学習機械 / バルクデータ解析 / オンサイト質量分析 / 迅速診断 / オンサイト分析 |
Outline of Final Research Achievements |
We constructed the rapid diagnosis system for human renal cell carcinoma and hepatocellular carcinoma using probe electrospray ionization-mass spectrometry (PESI-MS) and learning machine, and achieved over 90% coincidence of diagnosis with those judged by the conventional histopathology. To validate the applicability of this system, we applied PESI-MS to diagnosis of various cancers. In this study duration, we could collect the 22,000 mass spectra from glioma, oral squamous cell carcinoma, gastric cancer, colonic cancer, bladder cancer, and pancreatic cancer.
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Report
(4 results)
Research Products
(23 results)
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[Journal Article] Involvement of FKBP6 in hepatitis C virus replication.2015
Author(s)
Kasai H, Kawakami Y, Yokoe H, Yoshimura K, Matsuda M, Yasumoto J, Maekawa S, Yamashita A, Tanaka T, Ikeda M, Kato N, Okamoto T, Matsuura Y, Sakamoto N, Enomoto N, Takeda S, Fujii H, Tsubuki M, Kusunoki M, Moriishi K.
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Journal Title
Scientific reports
Volume: 5
Issue: 1
Pages: 16699-16699
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
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