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Construction of mass spectrometry based rapid cancer diagnosis system

Research Project

Project/Area Number 25713023
Research Category

Grant-in-Aid for Young Scientists (A)

Allocation TypePartial Multi-year Fund
Research Field Laboratory medicine
Research InstitutionUniversity of Yamanashi

Principal Investigator

YOSHIMURA Kentaro  山梨大学, 総合研究部, 助教 (70516921)

Project Period (FY) 2013-04-01 – 2016-03-31
Project Status Completed (Fiscal Year 2015)
Budget Amount *help
¥23,530,000 (Direct Cost: ¥18,100,000、Indirect Cost: ¥5,430,000)
Fiscal Year 2015: ¥7,540,000 (Direct Cost: ¥5,800,000、Indirect Cost: ¥1,740,000)
Fiscal Year 2014: ¥8,580,000 (Direct Cost: ¥6,600,000、Indirect Cost: ¥1,980,000)
Fiscal Year 2013: ¥7,410,000 (Direct Cost: ¥5,700,000、Indirect Cost: ¥1,710,000)
Keywords機械学習 / バルクデータ / がん診断 / 大気圧イオン化法 / リアルタイム質量分析 / メタボロミクス / 学習機械 / バルクデータ解析 / オンサイト質量分析 / 迅速診断 / オンサイト分析
Outline of Final Research Achievements

We constructed the rapid diagnosis system for human renal cell carcinoma and hepatocellular carcinoma using probe electrospray ionization-mass spectrometry (PESI-MS) and learning machine, and achieved over 90% coincidence of diagnosis with those judged by the conventional histopathology. To validate the applicability of this system, we applied PESI-MS to diagnosis of various cancers. In this study duration, we could collect the 22,000 mass spectra from glioma, oral squamous cell carcinoma, gastric cancer, colonic cancer, bladder cancer, and pancreatic cancer.

Report

(4 results)
  • 2015 Annual Research Report   Final Research Report ( PDF )
  • 2014 Annual Research Report
  • 2013 Annual Research Report
  • Research Products

    (23 results)

All 2016 2015 2014 2013 Other

All Journal Article (9 results) (of which Int'l Joint Research: 1 results,  Peer Reviewed: 7 results,  Open Access: 3 results,  Acknowledgement Compliant: 2 results) Presentation (8 results) (of which Invited: 1 results) Remarks (5 results) Patent(Industrial Property Rights) (1 results)

  • [Journal Article] Modulation of primary cilia length by melanin-concentrating hormone receptor 12016

    • Author(s)
      Hamamoto A, Yamato S, Katoh Y, Nakayama K, Yoshimura K, Takeda S, Kobayashi Y, *Saito Y
    • Journal Title

      Cellular Signalling

      Volume: 28 Issue: 6 Pages: 572

    • DOI

      10.1016/j.cellsig.2016.02.018

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] 相反する視座からの新しいがん診断支援装置の試み臨床病理2015

    • Author(s)
      竹田 扇、吉村 健太郎、田邉 國士
    • Journal Title

      臨床病理

      Volume: 63 Pages: 1083-1089

    • Related Report
      2015 Annual Research Report
  • [Journal Article] Involvement of FKBP6 in hepatitis C virus replication2015

    • Author(s)
      Kasai H, Kawakami Y, Yokoe H, Yoshimura K, Matsuda M, Yasumoto J, Maekawa S, Yamashita A, Tanaka T, Ikeda M, Kato N, Okamoto T, Matsuura Y, Sakamoto N, Enomoto N, Takeda S, Fujii H, Tsubuki M, Kusunoki M, Moriishi K.
    • Journal Title

      Scientific reports

      Volume: 5 Issue: 1 Pages: 16699-16699

    • DOI

      10.1038/srep16699

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Untreated and dried sample analysis by solid probe assisted nanoelectrospray ionization mass spectrometry2015

    • Author(s)
      Mridul Kanti Mandal, Subhrakanti Saha, Zhan Yu, Kentaro Yoshimura, Sen Takeda, Kenzo Hiraoka
    • Journal Title

      Analytical Methods

      Volume: 7 Pages: 2630-2635

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Development of Non-proximate Probe Electrospray Ionization for Real-Time Analysis of Living Animal2014

    • Author(s)
      Kentaro Yoshimura, Lee Chuin Chen, Hisashi Johno, Mayutaka Nakajima, Kenzo Hiraoka, Sen Takeda
    • Journal Title

      Mass Spectrometry

      Volume: 3 Pages: 1-7

    • NAID

      130004972836

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] 質量分析法と統計的学習機械を組み合わせた新規がん診断支援装置の開発2013

    • Author(s)
      竹田 扇、吉村 健太郎、出水 秀明、平岡 賢三、谷畑 博司、田邉 國士、中島 宏樹、堀 裕和
    • Journal Title

      島津評論

      Volume: 69 Pages: 203-210

    • Related Report
      2013 Annual Research Report
  • [Journal Article] Real-time diagnosis of chemically induced hepatocellular carcinoma using a novel mass spectrometry-based technique2013

    • Author(s)
      K. Yoshimura, M. K. Mandal, M . Hara, H. Fujii, L. C. Chen, K. Tanabe , K. Hiraoka and S. Takeda
    • Journal Title

      Analytical Biochemistry

      Volume: 441 Issue: 1 Pages: 32

    • DOI

      10.1016/j.ab.2013.06.017

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Direct electrospray ionization mass spectrometric profiling of real-world samples via a solid sampling probe2013

    • Author(s)
      Z. Yu, L. C. Chen, M. K. Mand al, K. Yoshimura, S. Takeda and K. Hiraoka
    • Journal Title

      Journal of The American Society for Mass Spectr ometry

      Volume: 24 Issue: 10 Pages: 1612

    • DOI

      10.1007/s13361-013-0697-7

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Biomolecular analysis and biological tissue diagnostics by electrospray ionization with a metal wire inserted gel-loading tip2013

    • Author(s)
      M. K. Mandal, K. Yoshimua, S. Saha, Z. Yu, S. Takeda and K. Hiraoka.
    • Journal Title

      Analytical Chemistry

      Volume: 86 Issue: 2 Pages: 987

    • DOI

      10.1021/ac403261s

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Presentation] ミエリン形成におけるヘッジホッグシグナルの機能とシグナル活性調節機構の解明2016

    • Author(s)
      吉村 健太郎
    • Organizer
      第121回日本解剖学会総会・全国学術集会
    • Place of Presentation
      ビッグバレットふくしま(福島県・郡山市)
    • Year and Date
      2016-03-28
    • Related Report
      2015 Annual Research Report
  • [Presentation] Hedgehog signaling specifically regulates the morphogenesis of Schwann cell in promyelinating stage2015

    • Author(s)
      吉村 健太郎
    • Organizer
      第38回 日本神経科学大会
    • Place of Presentation
      神戸国際会議場(兵庫県・神戸市)
    • Year and Date
      2015-07-30
    • Related Report
      2015 Annual Research Report
  • [Presentation] Development of real-time metabolomic analysis system and database construction/statistical analysis software2015

    • Author(s)
      吉村 健太郎
    • Organizer
      第63回質量分析総合討論会
    • Place of Presentation
      つくば国際会議場エポカルつくば(茨城県・つくば市)
    • Year and Date
      2015-06-19
    • Related Report
      2015 Annual Research Report
  • [Presentation] Developing a cancer diagnostics system: Towards on-site multi purpose gadgetry2014

    • Author(s)
      K.Yoshimura, L.C.Chen, K.Tanabe, M. Nakajima, S. Ninomiya, H. Hori, H. Izumi, K. Hiraoka, S. Takeda
    • Organizer
      20th International Mass Spectrometry Conference
    • Place of Presentation
      Centre International de Confrences Genve (Swiss)
    • Year and Date
      2014-08-25
    • Related Report
      2014 Annual Research Report
  • [Presentation] Development and Application of Diagnosis System Using Probe Electrospray Ionization and Dual Penalized Logistic Regression Machine2014

    • Author(s)
      K.Yoshimura, K.Tanabe, L.C.Chen, S.Ninomiya, H.Hori, H.Izumi, K.Hiraoka, S.Takeda
    • Organizer
      第62回質量分析総合討論会
    • Place of Presentation
      ホテル阪急エキスポパーク (大阪府・吹田市)
    • Year and Date
      2014-05-14
    • Related Report
      2014 Annual Research Report
  • [Presentation] Human cancer diagnosis by the electrospray ionization and Bayesian statistics

    • Author(s)
      Kentaro Yoshimura, Kunio Tanabe, Lee Chuin Chen, Hiroki Nakajima, Kenzo Hiraoka, Sen Takeda
    • Organizer
      4th Asia Oceania Mass Spectrometry Conference
    • Place of Presentation
      Taipei International Convention Center, Taipei, Taiwan
    • Related Report
      2013 Annual Research Report
  • [Presentation] ベイズ統計を用いた質量分析型がん診断装置の開発

    • Author(s)
      吉村健太郎・田邉國士・Lee Chuin Chen・二宮啓・堀裕和・中島宏樹・平岡賢三・竹田扇
    • Organizer
      第61回質量分析総合討論会
    • Place of Presentation
      つくば国際会議場エポカルつくば (茨城県、つくば市)
    • Related Report
      2013 Annual Research Report
  • [Presentation] 大気圧イオン化法および学習機械を用いた 質量分析型迅速診断システムの開発

    • Author(s)
      吉村健太郎
    • Organizer
      大阪大学質量分析シンポジウム、大阪大学未来研究イニシアティブ・グループ支援事業講演会
    • Place of Presentation
      大阪大学理学研究科、H棟701号室 (大阪府、豊中市)
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Remarks] 国立大学法人山梨大学研究者総覧

    • URL

      http://erdb.yamanashi.ac.jp/rdb/A_DispDetail.Scholar

    • Related Report
      2015 Annual Research Report
  • [Remarks] 山梨大学 大学院医学工学総合研究部 解剖学講座細胞生物学教室

    • URL

      http://www.cellbiology.jp

    • Related Report
      2015 Annual Research Report
  • [Remarks] 質量分析、メタボロミクス、データ解析

    • URL

      http://hh-bd.link

    • Related Report
      2015 Annual Research Report
  • [Remarks] 国立大学法人山梨大学研究者総覧

    • URL

      http://erdb.yamanashi.ac.jp/rdb/A_DispInfo.Scholar/3_51/39A95025371B8030.html

    • Related Report
      2014 Annual Research Report
  • [Remarks] 山梨大学大学院医学工学総合研究部解剖学講座細胞生物学教室ホームページ

    • URL

      http://www.cellbiology.jp/

    • Related Report
      2013 Annual Research Report
  • [Patent(Industrial Property Rights)] マススペクトル解析システム,方法およびプログラム2015

    • Inventor(s)
      吉村健太郎、城野悠志、船山慧、川井将敬、森優喜、竹田扇
    • Industrial Property Rights Holder
      国立大学法人山梨大学
    • Industrial Property Rights Type
      特許
    • Industrial Property Number
      2015-078992
    • Filing Date
      2015-04-08
    • Related Report
      2015 Annual Research Report

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Published: 2013-05-21   Modified: 2019-07-29  

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