Studies on development of examination of pathological condition using mass spectrometry imaging

• Project/Area Number: 25713024
• Research Category: Grant-in-Aid for Young Scientists (A)
• Allocation Type: Partial Multi-year Fund
• Research Field: Laboratory medicine
• Research Institution: Kindai University
• Principal Investigator: ZAIMA Nobuhiro 近畿大学, 農学部, 准教授 (40455572)
• Project Period (FY): 2013-04-01 – 2017-03-31
• Project Status: Completed (Fiscal Year 2016)
• Budget Amount: ¥18,070,000 (Direct Cost: ¥13,900,000、Indirect Cost: ¥4,170,000); Fiscal Year 2016: ¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000); Fiscal Year 2015: ¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000); Fiscal Year 2014: ¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000); Fiscal Year 2013: ¥6,370,000 (Direct Cost: ¥4,900,000、Indirect Cost: ¥1,470,000)
• Keywords: 質量分析イメージング / 病態検査 / 質量顕微鏡法 / イメージングマススペクトロメトリー / 代謝物イメージング / イメージング / MALDI-IMS / MALDI-MSI

Outline of Final Research Achievements

Mass microscopy (mass spectrometry imaging : MSI) is a method to visualize the spatial distribution of molecules in tissue section. This new method will provide important findings for the pathological examination. However, there is some limitations to apply this method to pathological examination. In this study, we establish a new method to enhance the sensitivity and specificity of MSI. In addition, we clarified the pathological meaning of data obtained from MSI analysis of biological samples.

Research Products

• [Journal Article] Adipocyte in vascular wall can induce the rupture of abdominal aortic aneurysm. (2016)
  • Author(s): Kugo H, Zaima N, Tanaka H, Mouri Y, Yanagimoto K, Hayamizu K, Hashimoto K, Sasaki T, Sano M, Yata T, Urano T, Setou M, Unno N, Moriyama T.
  • Journal Title: Sci Rep. Volume: 6 Issue: 1 Pages: 31268-31268
  • DOI: 10.1038/srep31268
  • Peer Reviewed / Open Access
• [Journal Article] Significant advancement of mass spectrometry imaging for food Chemistry (2016)
  • Author(s): Yukihiro Yoshimura, Naoko Goto-Inoue, Tatsuya Moriyama, Nobuhiro Zaima
  • Journal Title: Food Chemistry Volume: 210 Pages: 200-211
  • DOI: 10.1016/j.foodchem.2016.04.096
  • Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] 質量分析イメージング法による脂質の可視化 (2016)
  • Author(s): 久後 裕菜、山本 彩実、森山 達哉、財満 信宏
  • Journal Title: オレオサイエンス Volume: 5 Pages: 225-231
  • NAID: 130007589139
  • Acknowledgement Compliant
• [Journal Article] Characteristic Distribution Pattern of Lysophosphatidylcholine in Fibromuscular Dysplasia-Associated Visceral Artery Aneurysms Compared with Atherosclerotic Visceral Artery Aneurysms (2016)
  • Author(s): Tanaka, H., Zaima, N., Sasaki, T., Yamamoto, N., Inuzuka, K., Sano, M., Saito, T., Konno, T., Urano, T, Setou, M, Unno N
  • Journal Title: Journal of Atherosclerosis and Thrombosis Volume: 23 Issue: 6 Pages: 673-680
  • DOI: 10.5551/jat.32318
  • NAID: 130005154756
  • ISSN: 1340-3478, 1880-3873
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] The preventive effect of fish oil on abdominal aortic aneurysm development (2016)
  • Author(s): Hirona Kugo, Nobuhiro Zaima, Youhei Mouri, Hiroki Tanaka, Kenichi Yanagimoto, Tetsumei Urano, Naoki Unno, Tatsuya Moriyama
  • Journal Title: Bioscience, Biotechnology, and Biochemistry Volume: 未定 Issue: 6 Pages: 1186-1191
  • DOI: 10.1080/09168451.2016.1146073
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Applications of MALDI-IMS for Food Science (2016)
  • Author(s): 久後裕菜・山本彩実・森山達哉・財満信宏
  • Journal Title: Journal of the Mass Spectrometry Society of Japan Volume: 64 Issue: 1 Pages: 11-15
  • DOI: 10.5702/massspec.S16-03
  • NAID: 130005125541
  • ISSN: 1340-8097, 1880-4225, 1884-3271
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Hypoperfusion of the Adventitial Vasa Vasorum Develops an Abdominal Aortic Aneurysm (2015)
  • Author(s): Hiroki Tanaka, Nobuhiro Zaima, Takeshi Sasaki, Masaki Sano, Naoto Yamamoto, Takaaki Saito, Kazunori Inuzuka, Takahiro Hayasaka, Naoko Goto-Inoue, Yuki Sugiura, Kohji Sato, Hirona Kugo, Tatsuya Moriyama, Hiroyuki Konno, Mitsutoshi Setou, Naoki Unno
  • Journal Title: PLOS ONE Volume: 10
  • DOI: 10.5061/DRYAD.CM7PG
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Imaging Mass Spectrometry Reveals a Unique Distribution of Triglycerides in the Abdominal Aortic Aneurysmal Wall. (2015)
  • Author(s): Tanaka H, Zaima N, Sasaki T, Yamamoto N, Inuzuka K, Sano M, Saito T, Hayasaka T, Goto-Inoue N, Sato K, Kugo H, Moriyama T, Konno H, Setou M, Unno N.
  • Journal Title: J Vasc Res Volume: 52 Issue: 2 Pages: 127-135
  • DOI: 10.1159/000439169
  • Peer Reviewed / Open Access
• [Journal Article] Enhanced specificity for phosphatidylcholine analysis by positive ion mode MALDI-imaging mass spectrometry. (2014)
  • Author(s): Zaima, N., Yoshioka, S., Sato, Y., Shinano, S., Ikeda, Y., Moriyama, T
  • Journal Title: Rapid Commun. Mass Spectrom. Volume: 28 Issue: 13 Pages: 1453-1458
  • DOI: 10.1002/rcm.6917
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Matrix-assisted laser desorption/ionization imaging mass spectrometry - New technology for vascular pathology - (2014)
  • Author(s): Nobuhiro Zaima, Naoko Goto-Inoue, Tatsuya Moriyama
  • Journal Title: Journal of Vascular Research Volume: in press
  • Peer Reviewed
• [Presentation] イメージングマススペクトロメトリーの原理と分析事例 (2014)
  • Author(s): 財満 信宏
  • Organizer: 第45回 中部化学関係学協会支部連合秋季大会
  • Place of Presentation: 中部大学（愛知県春日井市）
  • Year and Date: 2014-11-29
  • Invited
• [Presentation] イメージングマススペクトロメトリーによる食品機能研究 (2014)
  • Author(s): 財満 信宏、森山 達哉
  • Organizer: 第５９回食品新素材研究会
  • Place of Presentation: 京都テルサ（京都府京都市）
  • Year and Date: 2014-09-14
  • Invited
• [Presentation] イメージング質量分析の食品科学への応用 (2014)
  • Author(s): 財満信宏
  • Organizer: 第41回BMSコンファレンス
  • Place of Presentation: 能登ロイヤルホテル（石川県羽咋郡）
  • Year and Date: 2014-07-09
  • Invited
• [Presentation] イメージングマススペクトロメトリー
  • Author(s): 財満信宏
  • Organizer: 第12回ホスファチジルセリン研究会
  • Place of Presentation: 東京海洋大学(東京都）
  • Invited
• [Presentation] イメージングマススペクトロメトリーによる機能性食品成分の可視化
  • Author(s): 財満信宏
  • Organizer: 第8回メタボロームシンポジウム
  • Place of Presentation: 九州大学（福岡県）
  • Invited
• [Presentation] イメージングマススペクトロメトリーによるスフィンゴ脂質の可視化
  • Author(s): 財満信宏
  • Organizer: 日本農芸化学会2014年度大会シンポジウム
  • Place of Presentation: 明治大学（神奈川県）
  • Invited
• [Presentation] Screening for triglyceride deposit cardiomyovasculopathy in type 2 diabetes mellitus patients
  • Author(s): Nobuhiro Zaima, Yoshihiko Ikeda, Hatsue Ishibashi-Ueda, Mitsutoshi Setou, Ken-ichi Hirano
  • Organizer: The 2nd International Symposium on Triglyceride Deposit Cardiomyovasculopathy and
  • Place of Presentation: 大阪大学中之島センター（大阪府）
• [Presentation] イメージングマススペクトロメトリー－質量分析で脂質を見る－
  • Author(s): 財満信宏
  • Organizer: 日本油化学会第52回年会
  • Place of Presentation: 東北大学（宮城県）
  • Invited
• [Book] Encyclopedia of Analytical Chemistry (2015)
  • Author(s): Nobuhiro Zaima, Naoko Goto-Inoue, Takahiro Hayasaka
  • Total Pages: 20
  • Publisher: John Wiley & Sons, Inc.