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Studies on development of examination of pathological condition using mass spectrometry imaging

Research Project

Project/Area Number 25713024
Research Category

Grant-in-Aid for Young Scientists (A)

Allocation TypePartial Multi-year Fund
Research Field Laboratory medicine
Research InstitutionKindai University

Principal Investigator

ZAIMA Nobuhiro  近畿大学, 農学部, 准教授 (40455572)

Project Period (FY) 2013-04-01 – 2017-03-31
Project Status Completed (Fiscal Year 2016)
Budget Amount *help
¥18,070,000 (Direct Cost: ¥13,900,000、Indirect Cost: ¥4,170,000)
Fiscal Year 2016: ¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2015: ¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2014: ¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2013: ¥6,370,000 (Direct Cost: ¥4,900,000、Indirect Cost: ¥1,470,000)
Keywords質量分析イメージング / 病態検査 / 質量顕微鏡法 / イメージングマススペクトロメトリー / 代謝物イメージング / イメージング / MALDI-IMS / MALDI-MSI
Outline of Final Research Achievements

Mass microscopy (mass spectrometry imaging : MSI) is a method to visualize the spatial distribution of molecules in tissue section. This new method will provide important findings for the pathological examination. However, there is some limitations to apply this method to pathological examination. In this study, we establish a new method to enhance the sensitivity and specificity of MSI. In addition, we clarified the pathological meaning of data obtained from MSI analysis of biological samples.

Report

(5 results)
  • 2016 Annual Research Report   Final Research Report ( PDF )
  • 2015 Annual Research Report
  • 2014 Annual Research Report
  • 2013 Annual Research Report
  • Research Products

    (19 results)

All 2016 2015 2014 Other

All Journal Article (10 results) (of which Int'l Joint Research: 1 results,  Peer Reviewed: 9 results,  Open Access: 4 results,  Acknowledgement Compliant: 7 results) Presentation (8 results) (of which Invited: 7 results) Book (1 results)

  • [Journal Article] Adipocyte in vascular wall can induce the rupture of abdominal aortic aneurysm.2016

    • Author(s)
      Kugo H, Zaima N, Tanaka H, Mouri Y, Yanagimoto K, Hayamizu K, Hashimoto K, Sasaki T, Sano M, Yata T, Urano T, Setou M, Unno N, Moriyama T.
    • Journal Title

      Sci Rep.

      Volume: 6 Issue: 1 Pages: 31268-31268

    • DOI

      10.1038/srep31268

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Significant advancement of mass spectrometry imaging for food Chemistry2016

    • Author(s)
      Yukihiro Yoshimura, Naoko Goto-Inoue, Tatsuya Moriyama, Nobuhiro Zaima
    • Journal Title

      Food Chemistry

      Volume: 210 Pages: 200-211

    • DOI

      10.1016/j.foodchem.2016.04.096

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] 質量分析イメージング法による脂質の可視化2016

    • Author(s)
      久後 裕菜、山本 彩実、森山 達哉、財満 信宏
    • Journal Title

      オレオサイエンス

      Volume: 5 Pages: 225-231

    • NAID

      130007589139

    • Related Report
      2016 Annual Research Report
    • Acknowledgement Compliant
  • [Journal Article] Characteristic Distribution Pattern of Lysophosphatidylcholine in Fibromuscular Dysplasia-Associated Visceral Artery Aneurysms Compared with Atherosclerotic Visceral Artery Aneurysms2016

    • Author(s)
      Tanaka, H., Zaima, N., Sasaki, T., Yamamoto, N., Inuzuka, K., Sano, M., Saito, T., Konno, T., Urano, T, Setou, M, Unno N
    • Journal Title

      Journal of Atherosclerosis and Thrombosis

      Volume: 23 Issue: 6 Pages: 673-680

    • DOI

      10.5551/jat.32318

    • NAID

      130005154756

    • ISSN
      1340-3478, 1880-3873
    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] The preventive effect of fish oil on abdominal aortic aneurysm development2016

    • Author(s)
      Hirona Kugo, Nobuhiro Zaima, Youhei Mouri, Hiroki Tanaka, Kenichi Yanagimoto, Tetsumei Urano, Naoki Unno, Tatsuya Moriyama
    • Journal Title

      Bioscience, Biotechnology, and Biochemistry

      Volume: 未定 Issue: 6 Pages: 1186-1191

    • DOI

      10.1080/09168451.2016.1146073

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Applications of MALDI-IMS for Food Science2016

    • Author(s)
      久後裕菜・山本彩実・森山達哉・財満信宏
    • Journal Title

      Journal of the Mass Spectrometry Society of Japan

      Volume: 64 Issue: 1 Pages: 11-15

    • DOI

      10.5702/massspec.S16-03

    • NAID

      130005125541

    • ISSN
      1340-8097, 1880-4225, 1884-3271
    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Hypoperfusion of the Adventitial Vasa Vasorum Develops an Abdominal Aortic Aneurysm2015

    • Author(s)
      Hiroki Tanaka, Nobuhiro Zaima, Takeshi Sasaki, Masaki Sano, Naoto Yamamoto, Takaaki Saito, Kazunori Inuzuka, Takahiro Hayasaka, Naoko Goto-Inoue, Yuki Sugiura, Kohji Sato, Hirona Kugo, Tatsuya Moriyama, Hiroyuki Konno, Mitsutoshi Setou, Naoki Unno
    • Journal Title

      PLOS ONE

      Volume: 10

    • DOI

      10.5061/DRYAD.CM7PG

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Imaging Mass Spectrometry Reveals a Unique Distribution of Triglycerides in the Abdominal Aortic Aneurysmal Wall.2015

    • Author(s)
      Tanaka H, Zaima N, Sasaki T, Yamamoto N, Inuzuka K, Sano M, Saito T, Hayasaka T, Goto-Inoue N, Sato K, Kugo H, Moriyama T, Konno H, Setou M, Unno N.
    • Journal Title

      J Vasc Res

      Volume: 52 Issue: 2 Pages: 127-135

    • DOI

      10.1159/000439169

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Enhanced specificity for phosphatidylcholine analysis by positive ion mode MALDI-imaging mass spectrometry.2014

    • Author(s)
      Zaima, N., Yoshioka, S., Sato, Y., Shinano, S., Ikeda, Y., Moriyama, T
    • Journal Title

      Rapid Commun. Mass Spectrom.

      Volume: 28 Issue: 13 Pages: 1453-1458

    • DOI

      10.1002/rcm.6917

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Matrix-assisted laser desorption/ionization imaging mass spectrometry - New technology for vascular pathology -2014

    • Author(s)
      Nobuhiro Zaima, Naoko Goto-Inoue, Tatsuya Moriyama
    • Journal Title

      Journal of Vascular Research

      Volume: in press

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Presentation] イメージングマススペクトロメトリーの原理と分析事例2014

    • Author(s)
      財満 信宏
    • Organizer
      第45回 中部化学関係学協会支部連合秋季大会
    • Place of Presentation
      中部大学(愛知県春日井市)
    • Year and Date
      2014-11-29
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] イメージングマススペクトロメトリーによる食品機能研究2014

    • Author(s)
      財満 信宏、森山 達哉
    • Organizer
      第59回食品新素材研究会
    • Place of Presentation
      京都テルサ(京都府京都市)
    • Year and Date
      2014-09-14
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] イメージング質量分析の食品科学への応用2014

    • Author(s)
      財満信宏
    • Organizer
      第41回BMSコンファレンス
    • Place of Presentation
      能登ロイヤルホテル(石川県羽咋郡)
    • Year and Date
      2014-07-09
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] イメージングマススペクトロメトリー

    • Author(s)
      財満信宏
    • Organizer
      第12回ホスファチジルセリン研究会
    • Place of Presentation
      東京海洋大学(東京都)
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] イメージングマススペクトロメトリーによる機能性食品成分の可視化

    • Author(s)
      財満信宏
    • Organizer
      第8回メタボロームシンポジウム
    • Place of Presentation
      九州大学(福岡県)
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] イメージングマススペクトロメトリーによるスフィンゴ脂質の可視化

    • Author(s)
      財満信宏
    • Organizer
      日本農芸化学会2014年度大会シンポジウム
    • Place of Presentation
      明治大学(神奈川県)
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] Screening for triglyceride deposit cardiomyovasculopathy in type 2 diabetes mellitus patients

    • Author(s)
      Nobuhiro Zaima, Yoshihiko Ikeda, Hatsue Ishibashi-Ueda, Mitsutoshi Setou, Ken-ichi Hirano
    • Organizer
      The 2nd International Symposium on Triglyceride Deposit Cardiomyovasculopathy and
    • Place of Presentation
      大阪大学中之島センター(大阪府)
    • Related Report
      2013 Annual Research Report
  • [Presentation] イメージングマススペクトロメトリー-質量分析で脂質を見る-

    • Author(s)
      財満信宏
    • Organizer
      日本油化学会第52回年会
    • Place of Presentation
      東北大学(宮城県)
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Book] Encyclopedia of Analytical Chemistry2015

    • Author(s)
      Nobuhiro Zaima, Naoko Goto-Inoue, Takahiro Hayasaka
    • Total Pages
      20
    • Publisher
      John Wiley & Sons, Inc.
    • Related Report
      2015 Annual Research Report

URL: 

Published: 2013-05-21   Modified: 2020-01-20  

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