| Budget Amount *help |
¥25,090,000 (Direct Cost: ¥19,300,000、Indirect Cost: ¥5,790,000)
Fiscal Year 2015: ¥10,400,000 (Direct Cost: ¥8,000,000、Indirect Cost: ¥2,400,000)
Fiscal Year 2014: ¥6,500,000 (Direct Cost: ¥5,000,000、Indirect Cost: ¥1,500,000)
Fiscal Year 2013: ¥8,190,000 (Direct Cost: ¥6,300,000、Indirect Cost: ¥1,890,000)
|
|---|
| Outline of Final Research Achievements |
Type I IFN are produced in response to viral infection and are key cytokines for the activation of innate immunity. The pathogen invasion is sensed by pattern-recognition receptors(PRRs) of innate immune system through the recognition of pathogen associated molecular patterns(PAMPs). The PRRs trigger the activation of intracellular signaling pathway, which leads to the induction of antimicrobial genes. RIG-I is the key PRR for detection of positive- and negative strand RNA viruses in the cytoplasm of cells and has an important triggering response to viruses, such as influenza A virus. However, the NS1 from influenza virus counters host antiviral defenses. In this study, the interaction of RIG-I and ZAPS is one of the keypoints, wherein NS1 inhibits RIG-I-mediated antiviral activity.
|
