Establishment of nutrient renal medicine -lessoned from starvation-

• Project/Area Number: 25713033
• Research Category: Grant-in-Aid for Young Scientists (A)
• Allocation Type: Partial Multi-year Fund
• Research Field: Kidney internal medicine
• Research Institution: Shiga University of Medical Science
• Principal Investigator: Kume Shinji 滋賀医科大学, 医学部, 助教 (00452235)
• Research Collaborator: TAKAGI Ayano ; YAMAHARA Mako ; TAGAWA Atsuko ; KUWAGATA Shogo ; Ono Shinya ; TANAKA Yuki
• Project Period (FY): 2013-04-01 – 2017-03-31
• Project Status: Completed (Fiscal Year 2016)
• Budget Amount: ¥24,180,000 (Direct Cost: ¥18,600,000、Indirect Cost: ¥5,580,000); Fiscal Year 2016: ¥3,250,000 (Direct Cost: ¥2,500,000、Indirect Cost: ¥750,000); Fiscal Year 2015: ¥5,850,000 (Direct Cost: ¥4,500,000、Indirect Cost: ¥1,350,000); Fiscal Year 2014: ¥5,720,000 (Direct Cost: ¥4,400,000、Indirect Cost: ¥1,320,000); Fiscal Year 2013: ¥9,360,000 (Direct Cost: ¥7,200,000、Indirect Cost: ¥2,160,000)
• Keywords: 腎臓 / 飢餓 / 糖尿病性腎症 / mTORC1 / オートファジー / NAD代謝 / 糖鎖修飾 / マイクロRNA / 生理学 / 内科 / 栄養 / 脂肪酸 / 糸球体上皮細胞 / 尿細管細胞

Outline of Final Research Achievements

This study revealed the novel physiological role of kidney to combat starvation. Renal autophagy is essential for hepatic and renal ketogenesis during starvation. Furthermore, we concluded that some renal nutrient-sensing signals and autophagy are associated with the pathogenesis of diabetic nephropathy. 1) Fatty acids are novel nutrient factors to regulate mTORC1 lysosomal localization and apoptosis in podocytes. 2) MicroRNA148b-3p inhibits mTORC1-dependent apoptosis in diabetes by repressing TNFR2 in proximal tubular cells. 3) Impaired podocyte- and proximal tubular cell-autophagy exacerbate proteinuria-related kidney injury in diabetic nephropathy. 4) 1-Methylnicotinamide ameliorates lipotoxicity-induced oxidative stress and cell death in kidney proximal tubular cells. 5) O-linked β-N-acetylglucosamine modification of proteins is essential for foot process maturation and survival in podocytes.

Research Products

• [Int'l Joint Research] Baylor College of Medicine(米国)
• [Journal Article] O-linked β-N-acetylglucosamine modification of proteins is essential for foot process maturation and survival in podocytes. (2017)
  • Author(s): Ono S, Kume S, Yasuda-Yamahara M, Yamahara K, Takeda N, Chin-Kanasaki M, Araki H, Sekine O, Yokoi H, Mukoyama M, Uzu T, Araki SI, Maegawa H.
  • Journal Title: Nephrol Dial Transplant. Volume: 未定 Issue: 9 Pages: 000-000
  • DOI: 10.1093/ndt/gfw463
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Stearoyl-CoA Desaturase-1 Protects Cells against Lipotoxicity-Mediated Apoptosis in Proximal Tubular Cells. (2017)
  • Author(s): Iwai T, Kume S, Chin-Kanasaki M, Kuwagata S, Araki H, Takeda N, Sugaya T, Uzu T, Maegawa H, Araki SI.
  • Journal Title: Int J Mol Sci. Volume: 17 Issue: 11 Pages: 1-17
  • DOI: 10.3390/ijms17111868
  • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] 糖尿病性腎症の発症進展におけるオートファジーの関与 (2017)
  • Author(s): 山原康佑, 山原真子, 久米真司
  • Journal Title: 日本腎臓学会誌 Volume: 59 Pages: 50-57
• [Journal Article] MicroRNA148b-3p inhibits mTORC1-dependent apoptosis in diabetes by repressing TNFR2 in proximal tubular cells. (2016)
  • Author(s): Kuwagata S, Kume S, Chin-Kanasaki M, Araki H, Araki S, Nakazawa J, Sugaya T, Koya D, Haneda M, Maegawa H, Uzu T.
  • Journal Title: Kidney Int. Volume: 90 Issue: 6 Pages: 1211-1225
  • DOI: 10.1016/j.kint.2016.06.036
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Emerging role of mammalian autophagy in ketogenesis to overcome starvation. (2016)
  • Author(s): Takagi A, Kume S, Maegawa H, Uzu T.
  • Journal Title: Autophagy. 2016;12(4):709-10. Volume: 12 Issue: 4 Pages: 709-10
  • DOI: 10.1080/15548627.2016.1151597
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] 老化と腎とカロリー制限 (2016)
  • Author(s): 久米真司
  • Journal Title: 腎臓内科・泌尿器科 Volume: 3 Pages: 368-375
  • NAID: 40022581950
• [Journal Article] 糖尿病性腎症における細胞内代謝異常 (2016)
  • Author(s): 久米 真司, 安田 真子, 山原 康佑
  • Journal Title: Pharma Medica Volume: 34 Pages: 51-54
• [Journal Article] 糖尿病性腎症の病態 (2016)
  • Author(s): 久米真司
  • Journal Title: 尿酸と血糖 Volume: 2
• [Journal Article] A very-low-protein diet ameliorates advanced diabetic nephropathy through autophagy induction by suppression of the mTORC1 pathway in Wistar fatty rats, an animal model of type 2 diabetes and obesity. (2016)
  • Author(s): Kitada M, Ogura Y, Suzuki T, Sen S, Lee SM, Kanasaki K, Kume S, Koya D.
  • Journal Title: Diabetologia Volume: 未定
  • Peer Reviewed
• [Journal Article] Mammalian autophagy is essential for hepatic and renal ketogenesis during starvation. (2016)
  • Author(s): Takagi A, Kume S, Kondo M, Nakazawa J, Chin-Kanasaki M, Araki H, Araki S, Koya D, Haneda M, Chano T, Matsusaka T, Nagao K, Adachi Y, Chan L, Maegawa H, Uzu T.
  • Journal Title: Sci Rep Volume: 6 Issue: 1 Pages: 18944-18944
  • DOI: 10.1038/srep18944
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Impaired podocyte autophagy exacerbates proteinuria in diabetic nephropathy. (2016)
  • Author(s): Tagawa A, Yasuda M, Kume S, Ymahara K, Nakazawa J, Chin-Kanasaki M, Araki H, Araki SI, Koya D, Asanuma K, Kim EH, Haneda M, Kajiwara N, Hayashi K, Ohashi H, Ugi S, Maegawa H, Uzu T
  • Journal Title: Diabetes. Volume: - Issue: 3 Pages: 755-767
  • DOI: 10.2337/db15-0473
  • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] Autophagy: A Novel Therapeutic Target for Diabetic Nephropathy. (2015)
  • Author(s): Kume S, Koya D.
  • Journal Title: Diabetes Metab J. Volume: 39 Issue: 6 Pages: 451-460
  • DOI: 10.4093/dmj.2015.39.6.451
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Emerging role of podocyte autophagy in the progression of diabetic nephropathy. (2015)
  • Author(s): Yasuda-Yamahara M, Kume S, Tagawa A, Maegawa H, Uzu T.
  • Journal Title: Autophagy Volume: 11 Issue: 12 Pages: 2385-2386
  • DOI: 10.1080/15548627.2015.1115173
  • Peer Reviewed / Open Access
• [Journal Article] 1-Methylnicotinamide ameliorates lipotoxicity-induced oxidative stress and cell death in kidney proximal tubular cells. (2015)
  • Author(s): Tanaka Yuki, Kume Shinji, Araki Hisazumi, Nakazawa Jun, Chin-Kanasaki Masami, Araki Shin-ichi, Nakagawa Fumiyuki, Koya Daisuke, Haneda Masakazu, Maegawa Hiroshi, Uzu Takashi.
  • Journal Title: Free Radic Biol Med. Volume: 89 Pages: 831-841
  • DOI: 10.1016/j.freeradbiomed.2015.10.414
  • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] Role of nutrient-sensing signals in the pathogenesis of diabetic nephropathy. (2014)
  • Author(s): Kume S, Koya D, Uzu T, Maegawa H.
  • Journal Title: Biomed Res Int. Volume: 2014 Pages: 315494-500
  • DOI: 10.1155/2014/315494
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Fatty acids are novel nutrient factors to regulate mTORC1 lysosomal localization and apoptosis in podocytes. (2014)
  • Author(s): Yasuda M, Tanaka Y, Kume S, Morita Y, Chin-Kanasaki M, Araki H, Isshiki K, Araki SI, Koya D, Haneda M, Kashiwagi A, Maegawa H, Uzu T.
  • Journal Title: Biochim Biophys Acta. Volume: 1842 Issue: 7 Pages: 1097-1108
  • DOI: 10.1016/j.bbadis.2014.04.001
  • Peer Reviewed / Open Access
• [Journal Article] Autophagy: emerging therapeutic target for diabetic nephropathy. (2014)
  • Author(s): Kume S, Yamahara K, Yasuda M, Maegawa H, Koya D.
  • Journal Title: Semin Nephrol. Volume: 34 Issue: 1 Pages: 9-16
  • DOI: 10.1016/j.semnephrol.2013.11.003
  • Peer Reviewed
• [Journal Article] 肥満と腎臓病 新規治療標的の開発を目指して (2014)
  • Author(s): 久米 真司, 前川 聡
  • Journal Title: 肥満研究 Volume: 20 Pages: 160-167
  • NAID: 40020321227
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Obesity-mediated autophagy insufficiency exacerbates proteinuria-induced tubulointerstitial lesions. (2013)
  • Author(s): Yamahara K, Kume S, Koya D, Tanaka Y, Morita Y, Chin-Kanasaki M, Araki H, Isshiki K, Araki S, Haneda M, Matsusaka T, Kashiwagi A, Maegawa H, Uzu T.
  • Journal Title: J Am Soc Nephrol. Volume: 24 Issue: 11 Pages: 1769-81
  • DOI: 10.1681/asn.2012111080
  • Peer Reviewed
• [Journal Article] The role of autophagy in the pathogenesis of diabetic nephropathy. (2013)
  • Author(s): Yamahara K, Yasuda M, Kume S, Koya D, Maegawa H, Uzu T.
  • Journal Title: J Diabetes Res Volume: 2013 Pages: 193757-193762
  • DOI: 10.1155/2013/193757
  • Peer Reviewed
• [Presentation] Role of autophagy in diabetic nephropathy and renal ketogenesis (2016)
  • Author(s): Shinji Kume
  • Organizer: Kidney Week 2016
  • Place of Presentation: Chicago, USA
  • Year and Date: 2016-11-16
  • Int'l Joint Research / Invited
• [Presentation] Role of autophagy in diabetic nephropathy and renal ketogenesis (2016)
  • Author(s): Shinji Kume
  • Organizer: Kidney Week 2016
  • Place of Presentation: Chicago, USA
  • Year and Date: 2016-11-15
  • Int'l Joint Research / Invited
• [Presentation] 糖尿病性腎症の克服を目指して (2016)
  • Author(s): 久米真司
  • Organizer: 第46回日本腎臓学会西部学術大会
  • Place of Presentation: 宮崎
  • Year and Date: 2016-10-14
  • Invited
• [Presentation] 糖尿病性腎症進展におけるポドサイト障害の関与 (2016)
  • Author(s): 久米真司
  • Organizer: 第46回日本腎臓学会西部学術大会
  • Place of Presentation: 宮崎
  • Year and Date: 2016-10-14
  • Invited
• [Presentation] 糖尿病に伴う糖・脂質代謝異常に起因する細胞内低酸素応答の破綻に着目した近位尿細管障害の病態解析 (2016)
  • Author(s): 桑形 尚吾, 久米 真司, 武田 尚子, 金崎 雅美, 荒木 久澄, 荒木 信一, 古家 大祐, 羽田 勝計, 宇津 貴, 前川 聡
  • Organizer: 第31回日本糖尿病合併症学会
  • Place of Presentation: 仙台
  • Year and Date: 2016-10-07
• [Presentation] 糖尿病性腎症の新規治療標的の解明を目指して (2016)
  • Author(s): 久米真司
  • Organizer: 第59回日本腎臓学会学術総会
  • Place of Presentation: 横浜
  • Year and Date: 2016-06-17
  • Invited
• [Presentation] 食事制限に学ぶ腎老化 (2016)
  • Author(s): 久米真司
  • Organizer: 第59回日本腎臓学会学術総会
  • Place of Presentation: 横浜
  • Year and Date: 2016-06-17
  • Invited
• [Presentation] 蛋白O-GlcNAc修飾は糸球体上皮細胞(ポドサイト)の機能維持に不可欠である (2016)
  • Author(s): 小野 真也, 山原 真子, 久米 真司, 中澤 純, 金崎 雅美, 荒木 久澄, 荒木 信一, 宇津 貴, 前川 聡
  • Organizer: 第59回日本腎臓学会学術総会
  • Place of Presentation: 横浜
  • Year and Date: 2016-06-17
• [Presentation] 腎老化 (2016)
  • Author(s): 久米真司
  • Organizer: 第59回日本腎臓学会学術総会
  • Place of Presentation: 横浜
  • Year and Date: 2016-06-17
  • Invited
• [Presentation] 低酸素ストレス応答の破綻に伴う近位尿細管障害に着目した新規糖尿病性腎症治療標的の同定 (2016)
  • Author(s): 桑形 尚吾, 久米 真司, 中澤 純, 金崎 雅美, 荒木 久澄, 荒木 信一, 古家 大祐, 羽田 勝計, 宇津 貴, 前川 聡
  • Organizer: 第59回日本糖尿病学会年次学術集会
  • Place of Presentation: 京都
  • Year and Date: 2016-05-19
• [Presentation] 創薬を目指した糖尿病性腎症研究の展望 腎老化と糖尿病性腎症対策におけるオートファジーの新たな役割 (2016)
  • Author(s): 久米真司
  • Organizer: 第59回日本糖尿病学会年次学術集会
  • Place of Presentation: 京都
  • Year and Date: 2016-05-19
  • Invited
• [Presentation] Renoprotective role of autophagy in kidney injury related to aging, obesity and diabetes (2016)
  • Author(s): 久米真司
  • Organizer: 第59回日本糖尿病学会年次学術集会
  • Place of Presentation: 京都
  • Year and Date: 2016-05-19
  • Invited
• [Presentation] 糖尿病性腎症の新規治療標的の解明を目指して (2015)
  • Author(s): 久米真司
  • Organizer: 第58回日本腎臓学会学術総会
  • Place of Presentation: 名古屋
  • Year and Date: 2015-06-05
  • Invited
• [Presentation] 糸球体上皮細胞におけるオートファジー不全は糖尿病性腎症における蛋白尿を増悪させる (2015)
  • Author(s): 田川 安都子, 安田 真子, 久米 真司, 中澤 純, 金崎 雅美, 荒木 久澄,荒木 信一, 古家 大祐, 羽田 勝計, 宇津 貴, 前川 聡
  • Organizer: 第58回日本腎臓学会学術総会
  • Place of Presentation: 名古屋
  • Year and Date: 2015-06-05
• [Presentation] 飢餓時の糖新生ならびにケトン産生における肝腎オートファジーの役割 (2015)
  • Author(s): 高木 彩乃, 久米 真司, 中澤 純, 金崎 雅美, 荒木 久澄, 荒木 信一, 宇津 貴, 前川 聡
  • Organizer: 第58回日本腎臓学会学術総会
  • Place of Presentation: 名古屋
  • Year and Date: 2015-06-05
• [Presentation] 肥満による近位尿細管細胞のオートファジー破綻が尿蛋白誘発腎障害を増悪させる (2015)
  • Author(s): 古家 大祐, 山原 康佑, 久米 真司
  • Organizer: 第15回日本抗加齢医学会総会
  • Place of Presentation: 福岡
  • Year and Date: 2015-05-29
• [Presentation] Sirtuin研究の深化と展望 SIRT1によるオートファジー制御 (2015)
  • Author(s): 久米真司
  • Organizer: 第58回日本糖尿病学会年次学術集会
  • Place of Presentation: 下関
  • Year and Date: 2015-05-21
  • Invited
• [Presentation] 糖尿病性腎症における近位尿細管障害をmTORC1依存性に制御する新規microRNAsの同定. (2015)
  • Author(s): 桑形 尚吾, 久米 真司, 中澤 純, 金崎 雅美, 荒木 久澄, 荒木 信一, 古家 大祐,羽田 勝計, 宇津 貴, 前川 聡
  • Organizer: 第58回日本糖尿病学会年次学術集会
  • Place of Presentation: 下関
  • Year and Date: 2015-05-21
• [Presentation] NAD代謝関連酵素Nicotinamide n-methyltransferase(NNMT)は糖尿病性腎症の脂肪酸結合アルブミンによる近位尿細管障害を抑制する (2015)
  • Author(s): 田中 裕紀, 久米 真司, 中澤 純, 金崎 雅美, 荒木 久澄, 荒木 信一, 古家 大祐, 羽田 勝計, 宇津 貴, 前川 聡
  • Organizer: 第58回日本糖尿病学会年次学術集会
  • Place of Presentation: 下関
  • Year and Date: 2015-05-21
• [Presentation] 糸球体上皮細胞の機能維持における蛋白O-GlcNAc修飾の役割 (2015)
  • Author(s): 小野 真也, 安田 真子, 久米 真司, 関根 理, 中澤 純, 金崎 雅美, 荒木 久澄, 荒木 信一, 古家 大祐, 羽田 勝計, 宇津 貴, 前川 聡
  • Organizer: 第58回日本糖尿病学会年次学術集会
  • Place of Presentation: 下関
  • Year and Date: 2015-05-21
• [Presentation] Protein O-GlcNAcylation is essential for maintaining normal podocyte function (2014)
  • Author(s): Shinya Ono, Mako Yasuda, Shinji Kume, Jun Nakazawa, Hisazumi Araki, Masami Chin-Kanasaki, Shin-ichi Araki, Daisuke Koya, Masakazu Haneda, Takashi Uzu, Hiroshi Maegawa
  • Organizer: American Society of Nephrology (Kidney Week 2014)
  • Place of Presentation: フィラデルフィア, アメリカ合衆国
  • Year and Date: 2014-11-11 – 2014-11-16
• [Presentation] Identification of novel miRNAs regulating proximal tubular cell apoptosis in diabetes (2014)
  • Author(s): Shogo Kuwagata, Shinji Kume, Hisazumi Araki, Masami Chin-Kanasaki, Shin-ichi Araki, Daisuke Koya, Masakazu Haneda, Takashi Uzu, Hiroshi Maegawa
  • Organizer: American Society of Nephrology (Kidney Week 2014)
  • Place of Presentation: フィラデルフィア, アメリカ合衆国
  • Year and Date: 2014-11-11 – 2014-11-16
• [Presentation] Nicotinamide n-methyltransferase (NNMT) is a novel enzyme that protects proximal tubular cells from lipotoxicity-mediated apoptosis (2014)
  • Author(s): Yuki Tanaka, Shinji Kume, Hisazumi Araki, Shin-ichi Araki, Daisuke Koya, Masakazu Haneda, Takashi Uzu, Hiroshi Maegawa
  • Organizer: American Society of Nephrology (Kidney Week 2014)
  • Place of Presentation: フィラデルフィア, アメリカ合衆国
  • Year and Date: 2014-11-11 – 2014-11-16
• [Presentation] 肥満関連腎障害とオートファジー (2014)
  • Author(s): 久米真司
  • Organizer: 第35回日本肥満学会
  • Place of Presentation: 宮崎
  • Year and Date: 2014-10-24 – 2014-10-25
  • Invited
• [Presentation] Role of autophagy in diabetic nephropathy (2014)
  • Author(s): Shinji Kume
  • Organizer: 2014 International Conference on Diabetes and Metabolism, Korea Diabetes Association
  • Place of Presentation: Ilsan, Republic of Korea
  • Year and Date: 2014-10-16 – 2014-10-18
  • Invited
• [Presentation] NAD代謝関連酵素Nicotinamide n-methyltransferase(NNMT)は糖尿病における脂肪毒性に伴う近位尿細管細胞障害を抑制する (2014)
  • Author(s): 田中 裕紀, 久米 真司, 荒木 久澄, 一色 啓二, 荒木 信一, 古家 大祐, 羽田 勝計, 宇津 貴, 前川 聡
  • Organizer: 第29回日本糖尿病合併症学会
  • Place of Presentation: 東京
  • Year and Date: 2014-10-03 – 2014-10-04
• [Presentation] NAD代謝関連酵素Nicotinamide n-methyltransferase(NNMT)は脂肪毒性に伴う近位尿細管細胞障害を抑制する (2014)
  • Author(s): 田中 裕紀, 久米 真司, 荒木 久澄, 一色 啓二, 荒木 信一, 古家 大祐, 羽田 勝計, 宇津 貴, 前川 聡
  • Organizer: 第57回日本腎臓学会学術総会
  • Place of Presentation: 横浜
  • Year and Date: 2014-07-04 – 2014-07-06
• [Presentation] 生活習慣病とCKDの相互連関 肥満が腎に与える影響 (2014)
  • Author(s): 山原 康佑, 久米 真司, 前川 聡, 宇津 貴
  • Organizer: 第57回日本腎臓学会学術総会
  • Place of Presentation: 横浜
  • Year and Date: 2014-07-04 – 2014-07-06
  • Invited
• [Presentation] The Role of Starvation-induced Autophagy in Gluconeogenesis and Ketogenesis (2014)
  • Author(s): Ayano Takagi, Shinji Kume, Yuki Tanaka, Hisazumi Araki, Keiji Isshiki, Shin-Ichi Araki, Takashi Uzu, Hiroshi Maegawa
  • Organizer: American Diabetes Association (ADA) 74th Scientific Sessions
  • Place of Presentation: サンフランシスコ, アメリカ合衆国
  • Year and Date: 2014-06-13 – 2014-06-17
• [Presentation] Podocyte Autophagy is Associated with the Progression of Proteinuria in Diabetic Nephropathy (2014)
  • Author(s): Mako Yasuda, Atsuko Tagawa, Shinji Kume, Yuki Tanaka, Kosuke Yamahara, Hisazumi Araki, Keiji Isshiki, Shin-ichi Araki, Daisuke Koya, Masakazu Haneda, Takashi Uzu and Hiroshi Maegawa
  • Organizer: American Diabetes Association (ADA) 74th Scientific Sessions
  • Place of Presentation: サンフランシスコ, アメリカ合衆国
  • Year and Date: 2014-06-13 – 2014-06-17
• [Presentation] 飢餓時の糖新生ならびにケトン産生におけるオートファジーの役割 (2014)
  • Author(s): 高木 彩乃, 久米 真司, 金崎 雅美, 荒木 久澄, 一色 啓二, 荒木 信一, 茶野 徳宏, 柏木 厚典, 宇津 貴, 前川 聡
  • Organizer: 第57回日本糖尿病学会年次学術集会
  • Place of Presentation: 大阪
  • Year and Date: 2014-05-22 – 2014-05-24
• [Presentation] 糸球体上皮細胞オートファジー不全は糖尿病性腎症における蛋白尿を増悪させる (2014)
  • Author(s): 安田 真子, 田川 安都子, 久米 真司, 田中 敬, 金崎 雅美, 荒木 久澄, 一色 啓二, 荒木 信一, 古家 大祐, 羽田 勝計, 柏木 厚典, 宇津 貴, 前川 聡
  • Organizer: 第57回日本糖尿病学会年次学術集会
  • Place of Presentation: 大阪
  • Year and Date: 2014-05-22 – 2014-05-24
• [Presentation] Insufficient podocyte autophagy is associated with the progression of proteinuria in diabetic nephropathy (2014)
  • Author(s): Mako Yasuda, Atsuko Tagawa, Shinji Kum, Yuki Tanaka, Shin-ichi Araki, Daisuke Koya, Masakazu Haneda, Takashi Uzu and Hiroshi Maegawa
  • Organizer: The 14th Asian Pacific Congress of Nephrology (APCN2014)
  • Place of Presentation: 東京
  • Year and Date: 2014-05-14 – 2014-05-17
• [Presentation] 異所性脂肪の概念と臨床展開 腎内脂肪蓄積の生理的役割から病態形成への関与まで (2014)
  • Author(s): 久米真司
  • Organizer: 第87回日本内分泌学会学術総会
  • Place of Presentation: 福岡
  • Year and Date: 2014-04-24 – 2014-04-26
  • Invited
• [Presentation] オートファジー機構の破綻と糖尿病性腎症との関わり (2013)
  • Author(s): 久米真司
  • Organizer: 第55回西部腎臓学会学術総会
  • Place of Presentation: 愛媛
  • Invited
• [Presentation] 飽和脂肪酸はmTORC1過剰亢進を介し糸球体上皮細胞のアポトーシスを惹起する. (2013)
  • Author(s): 安田 真子, 田中 敬, 久米 真司, 森田 善方, 荒木 久澄, 一色 啓二, 荒木 信一, 古家 大祐, 羽田 勝計, 柏木 厚典, 宇津 貴, 前川 聡.
  • Organizer: 第28回日本糖尿病合併症学会
  • Place of Presentation: 旭川
• [Book] 尿病腎症克服に残された課題へ挑戦 発症メカニズムに立脚した治療の将来展望 (2015)
  • Author(s): 久米 真司, 安田 真子, 山原 康佑
  • Total Pages: 7
  • Publisher: 月刊糖尿病
• [Book] 尿細管における糖代謝 (2015)
  • Author(s): 菅原 翔, 荒木 信一, 久米 真司
  • Total Pages: 6
  • Publisher: 腎臓内科・泌尿器科
• [Book] 高血圧の最新治療 (2013)
  • Author(s): 久米 真司, 猪木 健
  • Total Pages: 7
  • Publisher: フジメディカル出版
• [Book] BIO Clinica (2013)
  • Author(s): 久米 真司
  • Total Pages: 5
  • Publisher: 北隆館／ニュー・サイエンス社