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Establishment of nutrient renal medicine -lessoned from starvation-

Research Project

Project/Area Number 25713033
Research Category

Grant-in-Aid for Young Scientists (A)

Allocation TypePartial Multi-year Fund
Research Field Kidney internal medicine
Research InstitutionShiga University of Medical Science

Principal Investigator

Kume Shinji  滋賀医科大学, 医学部, 助教 (00452235)

Research Collaborator TAKAGI Ayano  
YAMAHARA Mako  
TAGAWA Atsuko  
KUWAGATA Shogo  
Ono Shinya  
TANAKA Yuki  
Project Period (FY) 2013-04-01 – 2017-03-31
Project Status Completed (Fiscal Year 2016)
Budget Amount *help
¥24,180,000 (Direct Cost: ¥18,600,000、Indirect Cost: ¥5,580,000)
Fiscal Year 2016: ¥3,250,000 (Direct Cost: ¥2,500,000、Indirect Cost: ¥750,000)
Fiscal Year 2015: ¥5,850,000 (Direct Cost: ¥4,500,000、Indirect Cost: ¥1,350,000)
Fiscal Year 2014: ¥5,720,000 (Direct Cost: ¥4,400,000、Indirect Cost: ¥1,320,000)
Fiscal Year 2013: ¥9,360,000 (Direct Cost: ¥7,200,000、Indirect Cost: ¥2,160,000)
Keywords腎臓 / 飢餓 / 糖尿病性腎症 / mTORC1 / オートファジー / NAD代謝 / 糖鎖修飾 / マイクロRNA / 生理学 / 内科 / 栄養 / 脂肪酸 / 糸球体上皮細胞 / 尿細管細胞
Outline of Final Research Achievements

This study revealed the novel physiological role of kidney to combat starvation. Renal autophagy is essential for hepatic and renal ketogenesis during starvation. Furthermore, we concluded that some renal nutrient-sensing signals and autophagy are associated with the pathogenesis of diabetic nephropathy. 1) Fatty acids are novel nutrient factors to regulate mTORC1 lysosomal localization and apoptosis in podocytes. 2) MicroRNA148b-3p inhibits mTORC1-dependent apoptosis in diabetes by repressing TNFR2 in proximal tubular cells. 3) Impaired podocyte- and proximal tubular cell-autophagy exacerbate proteinuria-related kidney injury in diabetic nephropathy. 4) 1-Methylnicotinamide ameliorates lipotoxicity-induced oxidative stress and cell death in kidney proximal tubular cells. 5) O-linked β-N-acetylglucosamine modification of proteins is essential for foot process maturation and survival in podocytes.

Report

(5 results)
  • 2016 Annual Research Report   Final Research Report ( PDF )
  • 2015 Annual Research Report
  • 2014 Annual Research Report
  • 2013 Annual Research Report
  • Research Products

    (61 results)

All 2017 2016 2015 2014 2013 Other

All Int'l Joint Research (1 results) Journal Article (20 results) (of which Int'l Joint Research: 4 results,  Peer Reviewed: 16 results,  Acknowledgement Compliant: 9 results,  Open Access: 6 results) Presentation (36 results) (of which Int'l Joint Research: 2 results,  Invited: 16 results) Book (4 results)

  • [Int'l Joint Research] Baylor College of Medicine(米国)

    • Related Report
      2015 Annual Research Report
  • [Journal Article] O-linked β-N-acetylglucosamine modification of proteins is essential for foot process maturation and survival in podocytes.2017

    • Author(s)
      Ono S, Kume S, Yasuda-Yamahara M, Yamahara K, Takeda N, Chin-Kanasaki M, Araki H, Sekine O, Yokoi H, Mukoyama M, Uzu T, Araki SI, Maegawa H.
    • Journal Title

      Nephrol Dial Transplant.

      Volume: 未定 Issue: 9 Pages: 000-000

    • DOI

      10.1093/ndt/gfw463

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Stearoyl-CoA Desaturase-1 Protects Cells against Lipotoxicity-Mediated Apoptosis in Proximal Tubular Cells.2017

    • Author(s)
      Iwai T, Kume S, Chin-Kanasaki M, Kuwagata S, Araki H, Takeda N, Sugaya T, Uzu T, Maegawa H, Araki SI.
    • Journal Title

      Int J Mol Sci.

      Volume: 17 Issue: 11 Pages: 1-17

    • DOI

      10.3390/ijms17111868

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] 糖尿病性腎症の発症進展におけるオートファジーの関与2017

    • Author(s)
      山原康佑, 山原真子, 久米真司
    • Journal Title

      日本腎臓学会誌

      Volume: 59 Pages: 50-57

    • Related Report
      2016 Annual Research Report
  • [Journal Article] MicroRNA148b-3p inhibits mTORC1-dependent apoptosis in diabetes by repressing TNFR2 in proximal tubular cells.2016

    • Author(s)
      Kuwagata S, Kume S, Chin-Kanasaki M, Araki H, Araki S, Nakazawa J, Sugaya T, Koya D, Haneda M, Maegawa H, Uzu T.
    • Journal Title

      Kidney Int.

      Volume: 90 Issue: 6 Pages: 1211-1225

    • DOI

      10.1016/j.kint.2016.06.036

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Emerging role of mammalian autophagy in ketogenesis to overcome starvation.2016

    • Author(s)
      Takagi A, Kume S, Maegawa H, Uzu T.
    • Journal Title

      Autophagy. 2016;12(4):709-10.

      Volume: 12 Issue: 4 Pages: 709-10

    • DOI

      10.1080/15548627.2016.1151597

    • Related Report
      2016 Annual Research Report 2015 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] 老化と腎とカロリー制限2016

    • Author(s)
      久米真司
    • Journal Title

      腎臓内科・泌尿器科

      Volume: 3 Pages: 368-375

    • NAID

      40022581950

    • Related Report
      2016 Annual Research Report
  • [Journal Article] 糖尿病性腎症における細胞内代謝異常2016

    • Author(s)
      久米 真司, 安田 真子, 山原 康佑
    • Journal Title

      Pharma Medica

      Volume: 34 Pages: 51-54

    • Related Report
      2016 Annual Research Report
  • [Journal Article] 糖尿病性腎症の病態2016

    • Author(s)
      久米真司
    • Journal Title

      尿酸と血糖

      Volume: 2

    • Related Report
      2016 Annual Research Report
  • [Journal Article] A very-low-protein diet ameliorates advanced diabetic nephropathy through autophagy induction by suppression of the mTORC1 pathway in Wistar fatty rats, an animal model of type 2 diabetes and obesity.2016

    • Author(s)
      Kitada M, Ogura Y, Suzuki T, Sen S, Lee SM, Kanasaki K, Kume S, Koya D.
    • Journal Title

      Diabetologia

      Volume: 未定

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Mammalian autophagy is essential for hepatic and renal ketogenesis during starvation.2016

    • Author(s)
      Takagi A, Kume S, Kondo M, Nakazawa J, Chin-Kanasaki M, Araki H, Araki S, Koya D, Haneda M, Chano T, Matsusaka T, Nagao K, Adachi Y, Chan L, Maegawa H, Uzu T.
    • Journal Title

      Sci Rep

      Volume: 6 Issue: 1 Pages: 18944-18944

    • DOI

      10.1038/srep18944

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Impaired podocyte autophagy exacerbates proteinuria in diabetic nephropathy.2016

    • Author(s)
      Tagawa A, Yasuda M, Kume S, Ymahara K, Nakazawa J, Chin-Kanasaki M, Araki H, Araki SI, Koya D, Asanuma K, Kim EH, Haneda M, Kajiwara N, Hayashi K, Ohashi H, Ugi S, Maegawa H, Uzu T
    • Journal Title

      Diabetes.

      Volume: - Issue: 3 Pages: 755-767

    • DOI

      10.2337/db15-0473

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Autophagy: A Novel Therapeutic Target for Diabetic Nephropathy.2015

    • Author(s)
      Kume S, Koya D.
    • Journal Title

      Diabetes Metab J.

      Volume: 39 Issue: 6 Pages: 451-460

    • DOI

      10.4093/dmj.2015.39.6.451

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Emerging role of podocyte autophagy in the progression of diabetic nephropathy.2015

    • Author(s)
      Yasuda-Yamahara M, Kume S, Tagawa A, Maegawa H, Uzu T.
    • Journal Title

      Autophagy

      Volume: 11 Issue: 12 Pages: 2385-2386

    • DOI

      10.1080/15548627.2015.1115173

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] 1-Methylnicotinamide ameliorates lipotoxicity-induced oxidative stress and cell death in kidney proximal tubular cells.2015

    • Author(s)
      Tanaka Yuki, Kume Shinji, Araki Hisazumi, Nakazawa Jun, Chin-Kanasaki Masami, Araki Shin-ichi, Nakagawa Fumiyuki, Koya Daisuke, Haneda Masakazu, Maegawa Hiroshi, Uzu Takashi.
    • Journal Title

      Free Radic Biol Med.

      Volume: 89 Pages: 831-841

    • DOI

      10.1016/j.freeradbiomed.2015.10.414

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Role of nutrient-sensing signals in the pathogenesis of diabetic nephropathy.2014

    • Author(s)
      Kume S, Koya D, Uzu T, Maegawa H.
    • Journal Title

      Biomed Res Int.

      Volume: 2014 Pages: 315494-500

    • DOI

      10.1155/2014/315494

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Fatty acids are novel nutrient factors to regulate mTORC1 lysosomal localization and apoptosis in podocytes.2014

    • Author(s)
      Yasuda M, Tanaka Y, Kume S, Morita Y, Chin-Kanasaki M, Araki H, Isshiki K, Araki SI, Koya D, Haneda M, Kashiwagi A, Maegawa H, Uzu T.
    • Journal Title

      Biochim Biophys Acta.

      Volume: 1842 Issue: 7 Pages: 1097-1108

    • DOI

      10.1016/j.bbadis.2014.04.001

    • Related Report
      2014 Annual Research Report 2013 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Autophagy: emerging therapeutic target for diabetic nephropathy.2014

    • Author(s)
      Kume S, Yamahara K, Yasuda M, Maegawa H, Koya D.
    • Journal Title

      Semin Nephrol.

      Volume: 34 Issue: 1 Pages: 9-16

    • DOI

      10.1016/j.semnephrol.2013.11.003

    • Related Report
      2014 Annual Research Report 2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 肥満と腎臓病 新規治療標的の開発を目指して2014

    • Author(s)
      久米 真司, 前川 聡
    • Journal Title

      肥満研究

      Volume: 20 Pages: 160-167

    • NAID

      40020321227

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Obesity-mediated autophagy insufficiency exacerbates proteinuria-induced tubulointerstitial lesions.2013

    • Author(s)
      Yamahara K, Kume S, Koya D, Tanaka Y, Morita Y, Chin-Kanasaki M, Araki H, Isshiki K, Araki S, Haneda M, Matsusaka T, Kashiwagi A, Maegawa H, Uzu T.
    • Journal Title

      J Am Soc Nephrol.

      Volume: 24 Issue: 11 Pages: 1769-81

    • DOI

      10.1681/asn.2012111080

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] The role of autophagy in the pathogenesis of diabetic nephropathy.2013

    • Author(s)
      Yamahara K, Yasuda M, Kume S, Koya D, Maegawa H, Uzu T.
    • Journal Title

      J Diabetes Res

      Volume: 2013 Pages: 193757-193762

    • DOI

      10.1155/2013/193757

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Presentation] Role of autophagy in diabetic nephropathy and renal ketogenesis2016

    • Author(s)
      Shinji Kume
    • Organizer
      Kidney Week 2016
    • Place of Presentation
      Chicago, USA
    • Year and Date
      2016-11-16
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Role of autophagy in diabetic nephropathy and renal ketogenesis2016

    • Author(s)
      Shinji Kume
    • Organizer
      Kidney Week 2016
    • Place of Presentation
      Chicago, USA
    • Year and Date
      2016-11-15
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] 糖尿病性腎症の克服を目指して2016

    • Author(s)
      久米真司
    • Organizer
      第46回日本腎臓学会西部学術大会
    • Place of Presentation
      宮崎
    • Year and Date
      2016-10-14
    • Related Report
      2016 Annual Research Report 2015 Annual Research Report
    • Invited
  • [Presentation] 糖尿病性腎症進展におけるポドサイト障害の関与2016

    • Author(s)
      久米真司
    • Organizer
      第46回日本腎臓学会西部学術大会
    • Place of Presentation
      宮崎
    • Year and Date
      2016-10-14
    • Related Report
      2016 Annual Research Report 2015 Annual Research Report
    • Invited
  • [Presentation] 糖尿病に伴う糖・脂質代謝異常に起因する細胞内低酸素応答の破綻に着目した近位尿細管障害の病態解析2016

    • Author(s)
      桑形 尚吾, 久米 真司, 武田 尚子, 金崎 雅美, 荒木 久澄, 荒木 信一, 古家 大祐, 羽田 勝計, 宇津 貴, 前川 聡
    • Organizer
      第31回日本糖尿病合併症学会
    • Place of Presentation
      仙台
    • Year and Date
      2016-10-07
    • Related Report
      2016 Annual Research Report
  • [Presentation] 糖尿病性腎症の新規治療標的の解明を目指して2016

    • Author(s)
      久米真司
    • Organizer
      第59回日本腎臓学会学術総会
    • Place of Presentation
      横浜
    • Year and Date
      2016-06-17
    • Related Report
      2016 Annual Research Report 2015 Annual Research Report
    • Invited
  • [Presentation] 食事制限に学ぶ腎老化2016

    • Author(s)
      久米真司
    • Organizer
      第59回日本腎臓学会学術総会
    • Place of Presentation
      横浜
    • Year and Date
      2016-06-17
    • Related Report
      2016 Annual Research Report
    • Invited
  • [Presentation] 蛋白O-GlcNAc修飾は糸球体上皮細胞(ポドサイト)の機能維持に不可欠である2016

    • Author(s)
      小野 真也, 山原 真子, 久米 真司, 中澤 純, 金崎 雅美, 荒木 久澄, 荒木 信一, 宇津 貴, 前川 聡
    • Organizer
      第59回日本腎臓学会学術総会
    • Place of Presentation
      横浜
    • Year and Date
      2016-06-17
    • Related Report
      2016 Annual Research Report
  • [Presentation] 腎老化2016

    • Author(s)
      久米真司
    • Organizer
      第59回日本腎臓学会学術総会
    • Place of Presentation
      横浜
    • Year and Date
      2016-06-17
    • Related Report
      2015 Annual Research Report
    • Invited
  • [Presentation] 低酸素ストレス応答の破綻に伴う近位尿細管障害に着目した新規糖尿病性腎症治療標的の同定2016

    • Author(s)
      桑形 尚吾, 久米 真司, 中澤 純, 金崎 雅美, 荒木 久澄, 荒木 信一, 古家 大祐, 羽田 勝計, 宇津 貴, 前川 聡
    • Organizer
      第59回日本糖尿病学会年次学術集会
    • Place of Presentation
      京都
    • Year and Date
      2016-05-19
    • Related Report
      2016 Annual Research Report
  • [Presentation] 創薬を目指した糖尿病性腎症研究の展望 腎老化と糖尿病性腎症対策におけるオートファジーの新たな役割2016

    • Author(s)
      久米真司
    • Organizer
      第59回日本糖尿病学会年次学術集会
    • Place of Presentation
      京都
    • Year and Date
      2016-05-19
    • Related Report
      2016 Annual Research Report
    • Invited
  • [Presentation] Renoprotective role of autophagy in kidney injury related to aging, obesity and diabetes2016

    • Author(s)
      久米真司
    • Organizer
      第59回日本糖尿病学会年次学術集会
    • Place of Presentation
      京都
    • Year and Date
      2016-05-19
    • Related Report
      2015 Annual Research Report
    • Invited
  • [Presentation] 糖尿病性腎症の新規治療標的の解明を目指して2015

    • Author(s)
      久米真司
    • Organizer
      第58回日本腎臓学会学術総会
    • Place of Presentation
      名古屋
    • Year and Date
      2015-06-05
    • Related Report
      2015 Annual Research Report
    • Invited
  • [Presentation] 糸球体上皮細胞におけるオートファジー不全は糖尿病性腎症における蛋白尿を増悪させる2015

    • Author(s)
      田川 安都子, 安田 真子, 久米 真司, 中澤 純, 金崎 雅美, 荒木 久澄,荒木 信一, 古家 大祐, 羽田 勝計, 宇津 貴, 前川 聡
    • Organizer
      第58回日本腎臓学会学術総会
    • Place of Presentation
      名古屋
    • Year and Date
      2015-06-05
    • Related Report
      2015 Annual Research Report
  • [Presentation] 飢餓時の糖新生ならびにケトン産生における肝腎オートファジーの役割2015

    • Author(s)
      高木 彩乃, 久米 真司, 中澤 純, 金崎 雅美, 荒木 久澄, 荒木 信一, 宇津 貴, 前川 聡
    • Organizer
      第58回日本腎臓学会学術総会
    • Place of Presentation
      名古屋
    • Year and Date
      2015-06-05
    • Related Report
      2015 Annual Research Report
  • [Presentation] 肥満による近位尿細管細胞のオートファジー破綻が尿蛋白誘発腎障害を増悪させる2015

    • Author(s)
      古家 大祐, 山原 康佑, 久米 真司
    • Organizer
      第15回日本抗加齢医学会総会
    • Place of Presentation
      福岡
    • Year and Date
      2015-05-29
    • Related Report
      2015 Annual Research Report
  • [Presentation] Sirtuin研究の深化と展望 SIRT1によるオートファジー制御2015

    • Author(s)
      久米真司
    • Organizer
      第58回日本糖尿病学会年次学術集会
    • Place of Presentation
      下関
    • Year and Date
      2015-05-21
    • Related Report
      2015 Annual Research Report
    • Invited
  • [Presentation] 糖尿病性腎症における近位尿細管障害をmTORC1依存性に制御する新規microRNAsの同定.2015

    • Author(s)
      桑形 尚吾, 久米 真司, 中澤 純, 金崎 雅美, 荒木 久澄, 荒木 信一, 古家 大祐,羽田 勝計, 宇津 貴, 前川 聡
    • Organizer
      第58回日本糖尿病学会年次学術集会
    • Place of Presentation
      下関
    • Year and Date
      2015-05-21
    • Related Report
      2015 Annual Research Report
  • [Presentation] NAD代謝関連酵素Nicotinamide n-methyltransferase(NNMT)は糖尿病性腎症の脂肪酸結合アルブミンによる近位尿細管障害を抑制する2015

    • Author(s)
      田中 裕紀, 久米 真司, 中澤 純, 金崎 雅美, 荒木 久澄, 荒木 信一, 古家 大祐, 羽田 勝計, 宇津 貴, 前川 聡
    • Organizer
      第58回日本糖尿病学会年次学術集会
    • Place of Presentation
      下関
    • Year and Date
      2015-05-21
    • Related Report
      2015 Annual Research Report
  • [Presentation] 糸球体上皮細胞の機能維持における蛋白O-GlcNAc修飾の役割2015

    • Author(s)
      小野 真也, 安田 真子, 久米 真司, 関根 理, 中澤 純, 金崎 雅美, 荒木 久澄, 荒木 信一, 古家 大祐, 羽田 勝計, 宇津 貴, 前川 聡
    • Organizer
      第58回日本糖尿病学会年次学術集会
    • Place of Presentation
      下関
    • Year and Date
      2015-05-21
    • Related Report
      2015 Annual Research Report
  • [Presentation] Protein O-GlcNAcylation is essential for maintaining normal podocyte function2014

    • Author(s)
      Shinya Ono, Mako Yasuda, Shinji Kume, Jun Nakazawa, Hisazumi Araki, Masami Chin-Kanasaki, Shin-ichi Araki, Daisuke Koya, Masakazu Haneda, Takashi Uzu, Hiroshi Maegawa
    • Organizer
      American Society of Nephrology (Kidney Week 2014)
    • Place of Presentation
      フィラデルフィア, アメリカ合衆国
    • Year and Date
      2014-11-11 – 2014-11-16
    • Related Report
      2014 Annual Research Report
  • [Presentation] Identification of novel miRNAs regulating proximal tubular cell apoptosis in diabetes2014

    • Author(s)
      Shogo Kuwagata, Shinji Kume, Hisazumi Araki, Masami Chin-Kanasaki, Shin-ichi Araki, Daisuke Koya, Masakazu Haneda, Takashi Uzu, Hiroshi Maegawa
    • Organizer
      American Society of Nephrology (Kidney Week 2014)
    • Place of Presentation
      フィラデルフィア, アメリカ合衆国
    • Year and Date
      2014-11-11 – 2014-11-16
    • Related Report
      2014 Annual Research Report
  • [Presentation] Nicotinamide n-methyltransferase (NNMT) is a novel enzyme that protects proximal tubular cells from lipotoxicity-mediated apoptosis2014

    • Author(s)
      Yuki Tanaka, Shinji Kume, Hisazumi Araki, Shin-ichi Araki, Daisuke Koya, Masakazu Haneda, Takashi Uzu, Hiroshi Maegawa
    • Organizer
      American Society of Nephrology (Kidney Week 2014)
    • Place of Presentation
      フィラデルフィア, アメリカ合衆国
    • Year and Date
      2014-11-11 – 2014-11-16
    • Related Report
      2014 Annual Research Report
  • [Presentation] 肥満関連腎障害とオートファジー2014

    • Author(s)
      久米真司
    • Organizer
      第35回日本肥満学会
    • Place of Presentation
      宮崎
    • Year and Date
      2014-10-24 – 2014-10-25
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] Role of autophagy in diabetic nephropathy2014

    • Author(s)
      Shinji Kume
    • Organizer
      2014 International Conference on Diabetes and Metabolism, Korea Diabetes Association
    • Place of Presentation
      Ilsan, Republic of Korea
    • Year and Date
      2014-10-16 – 2014-10-18
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] NAD代謝関連酵素Nicotinamide n-methyltransferase(NNMT)は糖尿病における脂肪毒性に伴う近位尿細管細胞障害を抑制する2014

    • Author(s)
      田中 裕紀, 久米 真司, 荒木 久澄, 一色 啓二, 荒木 信一, 古家 大祐, 羽田 勝計, 宇津 貴, 前川 聡
    • Organizer
      第29回日本糖尿病合併症学会
    • Place of Presentation
      東京
    • Year and Date
      2014-10-03 – 2014-10-04
    • Related Report
      2014 Annual Research Report
  • [Presentation] NAD代謝関連酵素Nicotinamide n-methyltransferase(NNMT)は脂肪毒性に伴う近位尿細管細胞障害を抑制する2014

    • Author(s)
      田中 裕紀, 久米 真司, 荒木 久澄, 一色 啓二, 荒木 信一, 古家 大祐, 羽田 勝計, 宇津 貴, 前川 聡
    • Organizer
      第57回日本腎臓学会学術総会
    • Place of Presentation
      横浜
    • Year and Date
      2014-07-04 – 2014-07-06
    • Related Report
      2014 Annual Research Report
  • [Presentation] 生活習慣病とCKDの相互連関 肥満が腎に与える影響2014

    • Author(s)
      山原 康佑, 久米 真司, 前川 聡, 宇津 貴
    • Organizer
      第57回日本腎臓学会学術総会
    • Place of Presentation
      横浜
    • Year and Date
      2014-07-04 – 2014-07-06
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] The Role of Starvation-induced Autophagy in Gluconeogenesis and Ketogenesis2014

    • Author(s)
      Ayano Takagi, Shinji Kume, Yuki Tanaka, Hisazumi Araki, Keiji Isshiki, Shin-Ichi Araki, Takashi Uzu, Hiroshi Maegawa
    • Organizer
      American Diabetes Association (ADA) 74th Scientific Sessions
    • Place of Presentation
      サンフランシスコ, アメリカ合衆国
    • Year and Date
      2014-06-13 – 2014-06-17
    • Related Report
      2014 Annual Research Report
  • [Presentation] Podocyte Autophagy is Associated with the Progression of Proteinuria in Diabetic Nephropathy2014

    • Author(s)
      Mako Yasuda, Atsuko Tagawa, Shinji Kume, Yuki Tanaka, Kosuke Yamahara, Hisazumi Araki, Keiji Isshiki, Shin-ichi Araki, Daisuke Koya, Masakazu Haneda, Takashi Uzu and Hiroshi Maegawa
    • Organizer
      American Diabetes Association (ADA) 74th Scientific Sessions
    • Place of Presentation
      サンフランシスコ, アメリカ合衆国
    • Year and Date
      2014-06-13 – 2014-06-17
    • Related Report
      2014 Annual Research Report
  • [Presentation] 飢餓時の糖新生ならびにケトン産生におけるオートファジーの役割2014

    • Author(s)
      高木 彩乃, 久米 真司, 金崎 雅美, 荒木 久澄, 一色 啓二, 荒木 信一, 茶野 徳宏, 柏木 厚典, 宇津 貴, 前川 聡
    • Organizer
      第57回日本糖尿病学会年次学術集会
    • Place of Presentation
      大阪
    • Year and Date
      2014-05-22 – 2014-05-24
    • Related Report
      2014 Annual Research Report
  • [Presentation] 糸球体上皮細胞オートファジー不全は糖尿病性腎症における蛋白尿を増悪させる2014

    • Author(s)
      安田 真子, 田川 安都子, 久米 真司, 田中 敬, 金崎 雅美, 荒木 久澄, 一色 啓二, 荒木 信一, 古家 大祐, 羽田 勝計, 柏木 厚典, 宇津 貴, 前川 聡
    • Organizer
      第57回日本糖尿病学会年次学術集会
    • Place of Presentation
      大阪
    • Year and Date
      2014-05-22 – 2014-05-24
    • Related Report
      2014 Annual Research Report
  • [Presentation] Insufficient podocyte autophagy is associated with the progression of proteinuria in diabetic nephropathy2014

    • Author(s)
      Mako Yasuda, Atsuko Tagawa, Shinji Kum, Yuki Tanaka, Shin-ichi Araki, Daisuke Koya, Masakazu Haneda, Takashi Uzu and Hiroshi Maegawa
    • Organizer
      The 14th Asian Pacific Congress of Nephrology (APCN2014)
    • Place of Presentation
      東京
    • Year and Date
      2014-05-14 – 2014-05-17
    • Related Report
      2014 Annual Research Report
  • [Presentation] 異所性脂肪の概念と臨床展開 腎内脂肪蓄積の生理的役割から病態形成への関与まで2014

    • Author(s)
      久米真司
    • Organizer
      第87回日本内分泌学会学術総会
    • Place of Presentation
      福岡
    • Year and Date
      2014-04-24 – 2014-04-26
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] オートファジー機構の破綻と糖尿病性腎症との関わり2013

    • Author(s)
      久米真司
    • Organizer
      第55回西部腎臓学会学術総会
    • Place of Presentation
      愛媛
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] 飽和脂肪酸はmTORC1過剰亢進を介し糸球体上皮細胞のアポトーシスを惹起する.2013

    • Author(s)
      安田 真子, 田中 敬, 久米 真司, 森田 善方, 荒木 久澄, 一色 啓二, 荒木 信一, 古家 大祐, 羽田 勝計, 柏木 厚典, 宇津 貴, 前川 聡.
    • Organizer
      第28回日本糖尿病合併症学会
    • Place of Presentation
      旭川
    • Related Report
      2013 Annual Research Report
  • [Book] 尿病腎症克服に残された課題へ挑戦 発症メカニズムに立脚した治療の将来展望2015

    • Author(s)
      久米 真司, 安田 真子, 山原 康佑
    • Total Pages
      7
    • Publisher
      月刊糖尿病
    • Related Report
      2015 Annual Research Report
  • [Book] 尿細管における糖代謝2015

    • Author(s)
      菅原 翔, 荒木 信一, 久米 真司
    • Total Pages
      6
    • Publisher
      腎臓内科・泌尿器科
    • Related Report
      2015 Annual Research Report
  • [Book] 高血圧の最新治療2013

    • Author(s)
      久米 真司, 猪木 健
    • Total Pages
      7
    • Publisher
      フジメディカル出版
    • Related Report
      2013 Annual Research Report
  • [Book] BIO Clinica2013

    • Author(s)
      久米 真司
    • Total Pages
      5
    • Publisher
      北隆館/ニュー・サイエンス社
    • Related Report
      2013 Annual Research Report

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Published: 2013-05-21   Modified: 2022-01-27  

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