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Research on therapeutic strategies through myelin regeneration for neurodegenerative diseases and spinal cord injury.

Research Project

Project/Area Number 25713035
Research Category

Grant-in-Aid for Young Scientists (A)

Allocation TypePartial Multi-year Fund
Research Field Neurology
Research InstitutionKeio University

Principal Investigator

Nakahara Jin  慶應義塾大学, 医学部, 助教 (60537950)

Project Period (FY) 2013-04-01 – 2016-03-31
Project Status Completed (Fiscal Year 2015)
Budget Amount *help
¥25,090,000 (Direct Cost: ¥19,300,000、Indirect Cost: ¥5,790,000)
Fiscal Year 2015: ¥8,060,000 (Direct Cost: ¥6,200,000、Indirect Cost: ¥1,860,000)
Fiscal Year 2014: ¥8,060,000 (Direct Cost: ¥6,200,000、Indirect Cost: ¥1,860,000)
Fiscal Year 2013: ¥8,970,000 (Direct Cost: ¥6,900,000、Indirect Cost: ¥2,070,000)
Keywords髄鞘 / オリゴデンドロサイト / 神経変性疾患 / 再生医療 / 新規治療戦略
Outline of Final Research Achievements

Myelin is an indispensable architecture of the central nervous system, required for saltatory conduction and for protection of neuronal cells. Clinically speaking, myelin is not only involved in demyelinating diseases such as multiple sclerosis, but also in Alzheimer's disease, Parkinson's disease, neurodegenerative diseases including ALS, psychiatric diseases including schizophrenia and major depression, or in trauma such as spinal cord injury.
In the current study, the role of myelin regeneration in these pathologies has been reconsidered, and we speculate that it is essential not only to solely induce remyelination but also provide a pathway to supply myelin-lipids to enable myelniogenesis, in which astrocytes' ketogenesis may have the most important role.

Report

(4 results)
  • 2015 Annual Research Report   Final Research Report ( PDF )
  • 2014 Annual Research Report
  • 2013 Annual Research Report
  • Research Products

    (16 results)

All 2016 2015 2014 2013 Other

All Journal Article (8 results) (of which Int'l Joint Research: 1 results,  Peer Reviewed: 2 results,  Open Access: 1 results) Presentation (6 results) (of which Invited: 4 results) Remarks (2 results)

  • [Journal Article] Application of q-Space Diffusion MRI for the Visualization of White Matter2016

    • Author(s)
      Fujiyoshi K, Hikishima K, Nakahara J, Tsuji O, Hata J, Konomi T, Nagai T, Shibata S, Kaneko S, Iwanami A, Momoshima S, Takahashi S, Jinzaki M, Suzuki N, Toyama Y, Nakamura M, Okano H.
    • Journal Title

      Journal of Neuroscience

      Volume: 36(9) Issue: 9 Pages: 2796-2808

    • DOI

      10.1523/jneurosci.1770-15.2016

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] 多発性硬化症と髄鞘再生2014

    • Author(s)
      中原仁
    • Journal Title

      MS Frontier

      Volume: 3 Pages: 12-20

    • Related Report
      2014 Annual Research Report
  • [Journal Article] α4インテグリン:ナタリズマブ2014

    • Author(s)
      中原仁
    • Journal Title

      Brain and Nerve

      Volume: 66 Pages: 1149-1158

    • Related Report
      2014 Annual Research Report
  • [Journal Article] オリゴデンドロサイトの動態2014

    • Author(s)
      中原仁、鈴木則宏
    • Journal Title

      Clinical Neuroscience

      Volume: 32 Pages: 1222-1224

    • Related Report
      2014 Annual Research Report
  • [Journal Article] フマル酸ジメチル(BG-12)2014

    • Author(s)
      高橋愼一、中原仁、鈴木則宏
    • Journal Title

      Clinical Neuroscience

      Volume: 32 Pages: 1287-1290

    • Related Report
      2014 Annual Research Report
  • [Journal Article] 多発性硬化症、視神経脊髄炎2014

    • Author(s)
      中原仁
    • Journal Title

      Brain Nursing

      Volume: 30 Pages: 1259-1261

    • Related Report
      2014 Annual Research Report
  • [Journal Article] Does neuroinflammation induce systemic aging?2013

    • Author(s)
      Jin Nakahara
    • Journal Title

      Cliical and Experimental Neuroimmunology

      Volume: 4 Issue: 2 Pages: 155-156

    • DOI

      10.1111/cen3.12038

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 多発性硬化症における脱髄と髄鞘再生2013

    • Author(s)
      谷川万里子, 中原仁, 鈴木則宏
    • Journal Title

      脳21

      Volume: 16 Pages: 427-431

    • Related Report
      2013 Annual Research Report
  • [Presentation] 多発性硬化症の髄鞘再生戦略と課題2015

    • Author(s)
      中原仁
    • Organizer
      第27回日本神経免疫学会学術集会
    • Place of Presentation
      長良川国際会議場(岐阜県岐阜市)
    • Year and Date
      2015-09-15
    • Related Report
      2015 Annual Research Report
    • Invited
  • [Presentation] 多発性硬化症におけるオリゴデンドロサイトの動態2015

    • Author(s)
      中原仁
    • Organizer
      第120回日本解剖学会総会全国学術集会・第92回日本生理学会大会・合同大会
    • Place of Presentation
      神戸
    • Year and Date
      2015-03-21 – 2015-03-23
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] 多発性硬化症における再髄鞘化療法開発の現状と課題2014

    • Author(s)
      中原仁
    • Organizer
      第36回日本生物学的精神医学会・第57回日本神経化学会大会・合同大会
    • Place of Presentation
      奈良
    • Year and Date
      2014-09-29 – 2019-10-01
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] 多発性硬化症の高次脳機能障害の発現機序-治療戦略考案に向けて-2014

    • Author(s)
      中原仁
    • Organizer
      第55回日本神経学会学術大会
    • Place of Presentation
      福岡
    • Year and Date
      2014-05-21 – 2014-05-24
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] Brain ketosis: A new therapeutic target for remyelination?2013

    • Author(s)
      Jin Nakahara et al
    • Organizer
      PACTRIMS 2013
    • Place of Presentation
      京都
    • Related Report
      2013 Annual Research Report
  • [Presentation] 髄鞘化を促進する髄鞘脂質前駆体の探索2013

    • Author(s)
      中原仁 他
    • Organizer
      第53回日本神経学会学術大会
    • Place of Presentation
      東京
    • Related Report
      2013 Annual Research Report
  • [Remarks] 慶應義塾大学医学部神経内科神経免疫グループ

    • URL

      http://www.keio-med.jp/neurology/nig/index.html

    • Related Report
      2015 Annual Research Report
  • [Remarks] 慶應義塾大学 中原仁

    • URL

      http://user.keio.ac.jp/~aa603146/

    • Related Report
      2015 Annual Research Report

URL: 

Published: 2013-05-21   Modified: 2019-07-29  

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