Research on therapeutic strategies through myelin regeneration for neurodegenerative diseases and spinal cord injury.
| Project/Area Number |
25713035
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| Research Category |
Grant-in-Aid for Young Scientists (A)
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| Allocation Type | Partial Multi-year Fund |
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| Research Field |
Neurology
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| Research Institution | Keio University |
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Principal Investigator |
Nakahara Jin 慶應義塾大学, 医学部, 助教 (60537950)
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥25,090,000 (Direct Cost: ¥19,300,000、Indirect Cost: ¥5,790,000)
Fiscal Year 2015: ¥8,060,000 (Direct Cost: ¥6,200,000、Indirect Cost: ¥1,860,000)
Fiscal Year 2014: ¥8,060,000 (Direct Cost: ¥6,200,000、Indirect Cost: ¥1,860,000)
Fiscal Year 2013: ¥8,970,000 (Direct Cost: ¥6,900,000、Indirect Cost: ¥2,070,000)
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| Keywords | 髄鞘 / オリゴデンドロサイト / 神経変性疾患 / 再生医療 / 新規治療戦略 |
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| Outline of Final Research Achievements |
Myelin is an indispensable architecture of the central nervous system, required for saltatory conduction and for protection of neuronal cells. Clinically speaking, myelin is not only involved in demyelinating diseases such as multiple sclerosis, but also in Alzheimer's disease, Parkinson's disease, neurodegenerative diseases including ALS, psychiatric diseases including schizophrenia and major depression, or in trauma such as spinal cord injury.
In the current study, the role of myelin regeneration in these pathologies has been reconsidered, and we speculate that it is essential not only to solely induce remyelination but also provide a pathway to supply myelin-lipids to enable myelniogenesis, in which astrocytes' ketogenesis may have the most important role.
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Report
(4 results)
Research Products
(16 results)
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[Journal Article] Application of q-Space Diffusion MRI for the Visualization of White Matter2016
Author(s)
Fujiyoshi K, Hikishima K, Nakahara J, Tsuji O, Hata J, Konomi T, Nagai T, Shibata S, Kaneko S, Iwanami A, Momoshima S, Takahashi S, Jinzaki M, Suzuki N, Toyama Y, Nakamura M, Okano H.
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Journal Title
Journal of Neuroscience
Volume: 36(9)
Issue: 9
Pages: 2796-2808
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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