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Investigation of induced stem cells treatment for epidermolysis bullosa

Research Project

Project/Area Number 25713041
Research Category

Grant-in-Aid for Young Scientists (A)

Allocation TypePartial Multi-year Fund
Research Field Dermatology
Research InstitutionHokkaido University

Principal Investigator

FUJITA Yasuyuki  北海道大学, 大学病院, 助教 (80374437)

Project Period (FY) 2013-04-01 – 2015-03-31
Project Status Completed (Fiscal Year 2014)
Budget Amount *help
¥26,130,000 (Direct Cost: ¥20,100,000、Indirect Cost: ¥6,030,000)
Fiscal Year 2014: ¥8,060,000 (Direct Cost: ¥6,200,000、Indirect Cost: ¥1,860,000)
Fiscal Year 2013: ¥18,070,000 (Direct Cost: ¥13,900,000、Indirect Cost: ¥4,170,000)
Keywords表皮水疱症 / iPS細胞 / 人工多能性幹細胞 / 造血系幹細胞 / 17型コラーゲン / 造血幹細胞移植
Outline of Final Research Achievements

Epidermolysis bullosa (EB) is a group of genodermatoses that cause blister formations from the congenital abnormality of anchor proteins between the epidermis and the dermis. There have been several strategies for the treatment of EB, and so far, cell therapies are the most promising approach because of the potential of systemic effects. We have proved that stem cell therapies, including bone marrow transplantation, hematopoietic stem cell transplantation, can ameliorate the phenotype and survival prognosis in the junctional EB model mice that lack type XVII collagen (Col17). In this study we explore the possibility of induced pluripotent stem cells (iPSCs) for the treatment of EB, via induction of hematopoietic cell lineages. We preformed iPSCs-derived hematopoietic stem cell transplantation to Col17 knockout / Col17 humanized mice, and some of them showed slight expression of the lacked murine Col17 in the re-epithelized skin injuries.

Report

(3 results)
  • 2014 Annual Research Report   Final Research Report ( PDF )
  • 2013 Annual Research Report
  • Research Products

    (9 results)

All 2015 2014 2013

All Journal Article (5 results) (of which Peer Reviewed: 5 results,  Acknowledgement Compliant: 1 results,  Open Access: 1 results) Presentation (4 results) (of which Invited: 2 results)

  • [Journal Article] MMP13 can be a useful differentiating marker between squamous cell carcinoma and benign hyperkeratotic lesions in recessive dystrophic epidermolysis bullosa.2015

    • Author(s)
      Hata H, Abe R, Suto A, Homma E, Fujita Y, Aoyagi S, Shimizu H.
    • Journal Title

      British Journal of Dermatology

      Volume: 172 Issue: 3 Pages: 769-773

    • DOI

      10.1111/bjd.13302

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Development of bullous pemphigoid during treatment of psoriatic onycho-pachydermo periostitis with ustekinumab.2015

    • Author(s)
      Nakayama C, Fujita Y, Watanabe M, Shimizu H
    • Journal Title

      Journal of Dermatology

      Volume: -

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed
  • [Journal Article] An annexin A1-FPR1 interaction contributes to necroptosis of keratinocytes in severe cutaneous adverse drug reactions.2014

    • Author(s)
      Saito N, Qiao H, Yanagi T, Shinkuma S, Nishimura K, Suto A, Fujita Y, Suzuki S, Nomura T, Nakamura H, Nagao K, Obuse C, Shimizu H, Abe R.
    • Journal Title

      Science Translational Medicine

      Volume: 6 Issue: 245 Pages: 245-295

    • DOI

      10.1126/scitranslmed.3008227

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Long-term follow-up of cultured epidermal autograft in a patient with recessive dystrophic epidermolysis bullosa2014

    • Author(s)
      Shinkuma S, Sawamura D, Fujita Y, Kawasaki H, Nakamura H, Inoie M, Nishie W, Shimizu H
    • Journal Title

      Acta Derm Venereol

      Volume: 94(1) Issue: 1 Pages: 98-99

    • DOI

      10.2340/00015555-1592

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Disturbed balance in three subpopulations of CD4(+)Foxp3(+) regulatory T cells in Stevens-Johnson syndrome and toxic epidermal necrolysis patients.2013

    • Author(s)
      Yoshioka N, Suto A, Abe R, Saito N, Murata J, Hayashi-Ujiie I, Hoshina D, Fujita Y, Shimizu H.
    • Journal Title

      Clin Immunol

      Volume: 148 Issue: 1 Pages: 89-91

    • DOI

      10.1016/j.clim.2013.04.002

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Presentation] GVHD-like manifestation in Thymoma: Thymoma-associated multiorgan autoimmunity.2015

    • Author(s)
      Muramatsu K, Fujita Y, Inokuma D, Tsukinaga I, Ito K, Nishiura Y, Shimizu H
    • Organizer
      The 23rd World Congress of Dermatology
    • Place of Presentation
      Vancouver Convention Centre (Vancouver, Canada)
    • Year and Date
      2015-06-08 – 2015-06-13
    • Related Report
      2014 Annual Research Report
  • [Presentation] RNA recognition motif of LEMD3 as a key player in the pathogenesis of Buschke-Ollendorff syndrome.2015

    • Author(s)
      Takashima S, Fujita Y, Suzuki S, Saito N, Shinkuma S, Nomura T, Shimizu H
    • Organizer
      The 71st Annual Meeting of the Society for Investigative Dermatology
    • Place of Presentation
      Hilton Atlanta Hotel (Atlanta, USA)
    • Year and Date
      2015-05-06 – 2015-05-09
    • Related Report
      2014 Annual Research Report
  • [Presentation] Epidermolysis bullosa in Japan: from bench to bedside.2014

    • Author(s)
      Fujita Y
    • Organizer
      The 37th Kung-Sun Oh Memorial Lecture
    • Place of Presentation
      Yonsei University (Seoul, Korea)
    • Year and Date
      2014-08-30
    • Related Report
      2014 Annual Research Report 2013 Annual Research Report
    • Invited
  • [Presentation] Novel strategies for the treatment of epidermolysis bullosa.2013

    • Author(s)
      Yasuyuki Fujita
    • Organizer
      The 1st Beijing International Forum of Pediatric Development.
    • Place of Presentation
      Beijing International Conference Center (Beijing, China)
    • Related Report
      2013 Annual Research Report
    • Invited

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Published: 2013-05-21   Modified: 2019-07-29  

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