Testing serotonin hypothesis of depression with optogenetics
| Project/Area Number |
25713043
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| Research Category |
Grant-in-Aid for Young Scientists (A)
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| Allocation Type | Partial Multi-year Fund |
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| Research Field |
Psychiatric science
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| Research Institution | Hokkaido University |
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Principal Investigator |
Ohmura Yu 北海道大学, 医学(系)研究科(研究院), 助教 (80597659)
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| Research Collaborator |
TANAKA KENJI 慶應義塾大学, 医学部, 准教授 (30329700)
YAMANAKA AKIHIRO 名古屋大学, 環境医学研究所, 教授 (60323292)
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| Project Period (FY) |
2013-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥16,250,000 (Direct Cost: ¥12,500,000、Indirect Cost: ¥3,750,000)
Fiscal Year 2016: ¥3,380,000 (Direct Cost: ¥2,600,000、Indirect Cost: ¥780,000)
Fiscal Year 2015: ¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2014: ¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2013: ¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
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| Keywords | うつ病 / 光遺伝学 / 精神薬理学 / 神経科学 |
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| Outline of Final Research Achievements |
“Serotonin hypothesis of depression” - decreased serotonin levels in the brain cause depression while increased serotonin levels in the brain attenuate depression - has been widely believed. However there is so far no direct evidence proving the relationships between serotonin and depression/depressive symptoms though the hypothesis was proposed in the 1950s. We addressed this issue by using recently-developed optogenetic tools. We used transgenic mice to manipulate serotonergic activity with light illumination. Our results demonstrated that optogenetic activation of serotonergic neurons decreased depressive-like behavior in mice while optogenetic suppression of serotonergic neurons did not affect it.
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Report
(5 results)
Research Products
(16 results)
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[Journal Article] Activation of pyramidal neurons in mouse medial prefrontal cortex enhances food seeking behavior while reducing impulsivity in the absence of an effect on food intake2016
Author(s)
Warthen D, Lambeth P, Ottolini M, Shi Y, Barker B, Gaykema R, Newmyer B, Ohmura Y, Perez-Reyes E, Guler A, Patel M, Scott M.
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Journal Title
Frontiers in Behavioral Neuroscience
Volume: 10
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
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