| Budget Amount *help |
¥19,760,000 (Direct Cost: ¥15,200,000、Indirect Cost: ¥4,560,000)
Fiscal Year 2015: ¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2014: ¥5,720,000 (Direct Cost: ¥4,400,000、Indirect Cost: ¥1,320,000)
Fiscal Year 2013: ¥8,710,000 (Direct Cost: ¥6,700,000、Indirect Cost: ¥2,010,000)
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| Outline of Final Research Achievements |
While virgin adult male mice attack pups, mice who have fathered pups care for them. To determine the neural mechanisms associated with paternal caregiving in mice, we performed whole-cell patch clamp recording in the rhomboid nucleus of the bed nulceus of the stria terminalis (BSTrh), which was activated after attack . By comparing of the amplitude of the postsynaptic potentials evoked by electrical stimulation among the virgin male, paternal males prior to the birth of their pups, and paternal males who have an experience with pups. We found increased inhibition in BSTrh depending on the experience of mice with pups. Excitotoxic lesioning of the medial preoptic area (MPOA), a region considered to be central to parental behavior, reversed this inhibition to the level seen in virgin males.
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