Social experience-dependent functional changes to synaptic input to the bed nucleus of the stria terminalis

• Project/Area Number: 25713044
• Research Category: Grant-in-Aid for Young Scientists (A)
• Allocation Type: Partial Multi-year Fund
• Research Field: Psychiatric science
• Research Institution: Hokkaido University (2014-2015); Institute of Physical and Chemical Research (2013)
• Principal Investigator: AMANO Taiju 北海道大学, 薬学研究科(研究院), 講師 (00591950)
• Project Period (FY): 2013-04-01 – 2016-03-31
• Project Status: Completed (Fiscal Year 2015)
• Budget Amount: ¥19,760,000 (Direct Cost: ¥15,200,000、Indirect Cost: ¥4,560,000); Fiscal Year 2015: ¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000); Fiscal Year 2014: ¥5,720,000 (Direct Cost: ¥4,400,000、Indirect Cost: ¥1,320,000); Fiscal Year 2013: ¥8,710,000 (Direct Cost: ¥6,700,000、Indirect Cost: ¥2,010,000)
• Keywords: 養育行動 / 攻撃行動 / 分界条床核 / 内側視索前野 / 電気生理学 / 薬理学 / ドパミン / 社会行動 / 神経回路

Outline of Final Research Achievements

While virgin adult male mice attack pups, mice who have fathered pups care for them. To determine the neural mechanisms associated with paternal caregiving in mice, we performed whole-cell patch clamp recording in the rhomboid nucleus of the bed nulceus of the stria terminalis (BSTrh), which was activated after attack . By comparing of the amplitude of the postsynaptic potentials evoked by electrical stimulation among the virgin male, paternal males prior to the birth of their pups, and paternal males who have an experience with pups. We found increased inhibition in BSTrh depending on the experience of mice with pups. Excitotoxic lesioning of the medial preoptic area (MPOA), a region considered to be central to parental behavior, reversed this inhibition to the level seen in virgin males.

Research Products

• [Journal Article] Distinct preoptic-BST nuclei dissociate paternal and infanticidal behavior in mice. (2015)
  • Author(s): Tsuneoka Y, Tokita K, Yoshihara C, Amano T, Esposito G, Huang AJ, Yu LM, Odaka Y, Shinozuka K, McHugh TJ, Kuroda KO.
  • Journal Title: EMBO J Volume: 34 Issue: 21 Pages: 2652-70
  • DOI: 10.15252/embj.201591942
  • Peer Reviewed
• [Presentation] The comparison of behavioral pattern toward pups and synaptic transmission in the rhomboid nucleus of the bed nucleus of the stria terminalis between mice before after weaning (2016)
  • Author(s): Taiju Amano, Sayaka Shindo, Chihiro Yoshihara, Yousuke Tusneoka, Masabumi Minami, Kumi O Kuroda
  • Organizer: 第39回日本神経科学大会
  • Place of Presentation: パシフィコ横浜（神奈川県横浜市）
  • Year and Date: 2016-07-20
• [Presentation] Rethinking of the boundary and the projection pattern of the medial amygdala subnuclei (2016)
  • Author(s): Kazuki Ito, Masabumi Minami, Taiju Amano
  • Organizer: 第39回日本神経科学大会
  • Place of Presentation: パシフィコ横浜（神奈川県横浜市）
  • Year and Date: 2016-07-20
• [Presentation] マウス父性行動および喰殺行動に関与する神経回路 (2016)
  • Author(s): Ken-Ichi Tokita, Yousuke Tsuneoka, Taiju Amano, Manami Sato, Kumi O Kuroda
  • Organizer: 第39回日本神経科学大会
  • Place of Presentation: パシフィコ横浜（神奈川県横浜市）
  • Year and Date: 2016-07-20
• [Presentation] The regulation of male pup-toward behavior by sexual hormones (2016)
  • Author(s): Kazuki Ito, Sayaka Shindo, Chihiro Yoshihara, Kumi Kuroda, Masabumi Minami, Taiju Amano
  • Organizer: 30th CINP World Congress of Neuropyschopharmacology
  • Place of Presentation: Seoul, Korea
  • Year and Date: 2016-07-05
  • Int'l Joint Research
• [Presentation] 性ホルモンを介した養育行動の調節機構 (2016)
  • Author(s): 伊藤和貴、進藤さやか、吉原千尋、黒田公美、南雅文、天野大樹
  • Organizer: 第46回日本神経精神薬理学会年会
  • Place of Presentation: Seoul, Korea
  • Year and Date: 2016-07-02
• [Presentation] Neural circuits controlling pup-directed behaviors in male mice (2016)
  • Author(s): Ken-Ichi Tokita, Yousuke Tsuneoka, Taiju Amano, Manami Sato, Kumi O Kuroda
  • Organizer: 17th International Symposium on Olfaction and Taste
  • Place of Presentation: パシフィコ横浜（神奈川県横浜市）
  • Year and Date: 2016-06-05
  • Int'l Joint Research
• [Presentation] 雄マウスの養育行動の発現と神経可塑的変化 (2016)
  • Author(s): 天野大樹、伊藤和貴、恒岡洋右、進藤さやか、吉原千尋、南雅文、黒田公美
  • Organizer: 第11回環境生理学プレコングレス
  • Place of Presentation: 北海道大学大学院医学研究科フラテ会館（北海道札幌市）
  • Year and Date: 2016-03-21
• [Presentation] Medial preoptic area is involved in the regulation of the inhibitory synaptic transmission in the posterior bed nucleus of the stria terminalis (2015)
  • Author(s): Taiju Amano, Chihiro Yoshihara, Sayaka Shindo, Yousuke Tsuneoka, Kazuki Ito, Masabumi Minami, Kumi O Kuroda
  • Organizer: Gordon Research Conference ‘Amygdala In Health & Disease'
  • Place of Presentation: Eaton, USA
  • Year and Date: 2015-08-05
  • Int'l Joint Research
• [Presentation] The effect of gonadal hormone on inhibitory synaptic transmission in the posterior bed nucleus of the stria terminalis (2015)
  • Author(s): Taiju Amano, Chihiro Yoshihara, Sayaka Shindo, Yousuke Tsuneoka, Ito Kazuki, Minami Masabumi, Kumi O Kuroda
  • Organizer: 第38回神経科学大会
  • Place of Presentation: 神戸国際会議場、神戸国際展示場（兵庫県神戸市）
  • Year and Date: 2015-07-29
• [Presentation] The electrophysiological analysis of the posterior division of the bed nucleus of stria terminalis in father mice. (2014)
  • Author(s): Amano T, Tsuneoka Y, Shindo S, Yoshihara C, Kuroda KO
  • Organizer: 44th Society for Neuroscience
  • Place of Presentation: Washington D.C.
  • Year and Date: 2014-11-15 – 2014-11-19
• [Presentation] 父性発現と神経可塑的変化 (2014)
  • Author(s): 天野大樹
  • Organizer: 感覚刺激・薬物による快・不快情動生成機構とその破綻 （情動研究会）
  • Place of Presentation: 岡崎市
  • Year and Date: 2014-10-07 – 2014-10-08
  • Invited
• [Presentation] Paternal behavior and inhibitory synaptic transmission in the bed nucleus of stria terminalis. (2014)
  • Author(s): Amano Taiju, Tsuneoka Yousuke, Shindo Sayaka, Yoshihara Chihiro, Kuroda O Kumi
  • Organizer: 第37回日本神経科学大会
  • Place of Presentation: 横浜市
  • Year and Date: 2014-09-11 – 2014-09-13
• [Presentation] Comparison of synaptic transmission in the bed nucleus of stria terminalis before and after being father. (2014)
  • Author(s): Amano T, Tsuneoka Y, Shindo S, Yoshihara C, Kuroda KO
  • Organizer: 9th FENS meeting
  • Place of Presentation: Milan, Italy
  • Year and Date: 2014-07-05 – 2014-07-09
• [Presentation] Comparison of synaptic transmission in the bed nucleus of stria terminalis before and after being father. (2014)
  • Author(s): Amano T, Tsuneoka Y, Shindo S, Yoshihara C, Kuroda KO
  • Organizer: 9th FENS Forum of Neuroscience
  • Place of Presentation: Milan, Italy
• [Presentation] 去勢による養育行動変化と神経可塑的変化 (2013)
  • Author(s): 天野大樹,吉原千尋, 進藤さやか,恒岡洋右,黒田公美
  • Organizer: 第3回社会神経科学研究会
  • Place of Presentation: 岡崎、愛知
• [Presentation] Activity changes of the posterior division of the bed nucleus of stria terminalis after being father. (2013)
  • Author(s): Amano T, Tsuneoka Y, Shindo S, Yoshihara C, Kuroda KO
  • Organizer: Gordon Research Conference ‘Amygdala In Health & Disease’
  • Place of Presentation: Easton, MA, USA
• [Presentation] The effect of dopamine on the posterior division of bed nucleus of stria terminalis after being father. (2013)
  • Author(s): Amano T, Tsuneoka Y, Shindo S, Yoshihara C, Kuroda KO
  • Organizer: 5th Parental Brain Conference
  • Place of Presentation: Regensburg, Germany
• [Remarks] マウスの「父性の目覚め」に重要な脳部位を発見
  • URL: http://www.riken.jp/pr/press/2015/20150930_1/
• [Remarks] 親和性社会行動研究チーム
  • URL: http://asb.brain.riken.jp/research2_j.html