Development of a novel CYP11B2-specific imaging agent for detection of unilateral subtypes of primary aldosteronism
Project/Area Number |
25713046
|
Research Category |
Grant-in-Aid for Young Scientists (A)
|
Allocation Type | Partial Multi-year Fund |
Research Field |
Radiation science
|
Research Institution | Kyoto Pharmaceutical University (2016) Kyoto University (2013-2015) |
Principal Investigator |
|
Project Period (FY) |
2013-04-01 – 2017-03-31
|
Project Status |
Completed (Fiscal Year 2016)
|
Budget Amount *help |
¥25,610,000 (Direct Cost: ¥19,700,000、Indirect Cost: ¥5,910,000)
Fiscal Year 2015: ¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2014: ¥8,060,000 (Direct Cost: ¥6,200,000、Indirect Cost: ¥1,860,000)
Fiscal Year 2013: ¥13,520,000 (Direct Cost: ¥10,400,000、Indirect Cost: ¥3,120,000)
|
Keywords | 原発性アルドステロン症 / アルドステロン産生腺腫 / PET/SPECT用分子イメージングプローブ / CYP11B2選択的化合物 / PET/SPECT用イメージングプローブ / CYP11B2選択的イメージングプローブ / CYP11B2選択的 / CYP11B2選択性 / テトラヒドロキノリン骨格 / 123I標識体 |
Outline of Final Research Achievements |
Primary aldosteronism (PA) is the most common and surgically curable form of endocrine hypertension, accounting for 5%-10% of all patients with hypertension. Approximately 60% patients with PA exhibit bilateral form causing aldosterone hypersecretion and require medical treatment with mineralocorticoid receptor antagonists. The remaining 40% exhibit the unilateral form causing hypersecretion, e.g., aldosterone-producing adenoma (APA); in these patients, hypertension and hyperaldosteronism can be cured by unilateral laparoscopic adrenalectomy. Therefore, an accurate method for distinguishing unilateral from bilateral adrenal disease is critical for patients who wish to pursue the surgical option. Aldosterone synthase (CYP11B2) is responsible for the majority of cases clinically diagnosed as primary aldosteronism. CYP11B2 is highly homologous to 11β-hydroxylase (CYP11B1). In this study, we have developed a PET/SPECT imaging probe with higher selectivity for CYP11B2 than CYP11B1.
|
Report
(5 results)
Research Products
(9 results)
-
-
[Journal Article] A novel CYP11B2-specific positron emission tomography imaging agent for detection of aldosterone-producing adenomas2016
Author(s)
Abe, T., Naruse, M., Young Jr. W. F., Kobashi, N., Doi, Y., Izawa, A., Akama, K., Okumura, Y., Ikenaga, M., Kimura, H., Saji, H., Mukai, K., Matsumoto, H.
-
Journal Title
J. Clin. Endocrinol. Metab.
Volume: 101
Issue: 3
Pages: 1008-1015
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
-
-
-
[Presentation] A novel CYP11B2-specific imaging agent for detection of aldosterone-producing adenomas2016
Author(s)
Tsutomu Abe, Mitsuhide Naruse, William F Young, Nobuya Kobashi, Yoshihiro Doi, Akihiro Izawa, Kei Akama, Yuki Okumura, Miho Ikenaga, Hiroyuki Kimura, Hideo Saji, Kuniaki Mukai, and Hiroki Matsumoto
Organizer
Endocrine Society's 98th Annual Meeting and Expo
Place of Presentation
Boston, USA
Year and Date
2016-04-01
Related Report
Int'l Joint Research
-
-
-
-