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Prediction of the wall property and rupture risk of cerebral aneurysms based on the computational fluid dynamics

Research Project

Project/Area Number 25713051
Research Category

Grant-in-Aid for Young Scientists (A)

Allocation TypePartial Multi-year Fund
Research Field Neurosurgery
Research InstitutionTohoku University

Principal Investigator

Niizuma Kuniyasu  東北大学, 医工学研究科, 助教 (10643330)

Research Collaborator SUGIYAMA SHIN-ICHIRO  東北大学病院, 非常勤講師 (30623152)
NAKAGAWA ATSUHIRO  東北大学病院, 助教 (10447162)
HAYASE TOSHIYUKI  東北大学, 流体科学研究所, 教授 (30135313)
OHTA MAKOTO  東北大学, 流体科学研究所, 准教授 (20400418)
FUNAMOTO KENICHI  東北大学, 流体科学研究所, 助教 (70451630)
ARAFUNE TATSUHIKO  東京電機大学, 理工学部, 助教 (50376597)
WASHIO TOSHIKATSU  独立行政法人産業技術総合研究所, ヒューマンライフテクノロジー研究部門, 主任研究員 (40358370)
Project Period (FY) 2013-04-01 – 2016-03-31
Project Status Completed (Fiscal Year 2015)
Budget Amount *help
¥25,480,000 (Direct Cost: ¥19,600,000、Indirect Cost: ¥5,880,000)
Fiscal Year 2015: ¥6,500,000 (Direct Cost: ¥5,000,000、Indirect Cost: ¥1,500,000)
Fiscal Year 2014: ¥7,150,000 (Direct Cost: ¥5,500,000、Indirect Cost: ¥1,650,000)
Fiscal Year 2013: ¥11,830,000 (Direct Cost: ¥9,100,000、Indirect Cost: ¥2,730,000)
Keywords数値流体力学 / 脳動脈瘤 / くも膜下出血 / 数値流体解析 / 脳血管障害学 / 脳神経外科学 / 動脈硬化
Outline of Final Research Achievements

The purpose of this study was to build a large-scale cerebral aneurysm database including computational fluid dynamics (CFD) analysis, and to predict wall property and rupture risk. In the 3 years around 500 cases were included. Based on the database, we reported that the yellowish wall can be predicted by CFD. In addition, we revealed that rupture risk or recanalization after coil embolization could be predicted by CFD.
Further analysis based on the database and outpatient clinic system are planned.

Report

(4 results)
  • 2015 Annual Research Report   Final Research Report ( PDF )
  • 2014 Annual Research Report
  • 2013 Annual Research Report
  • Research Products

    (12 results)

All 2016 2015 2014 2013

All Journal Article (3 results) (of which Acknowledgement Compliant: 1 results,  Peer Reviewed: 1 results) Presentation (9 results) (of which Int'l Joint Research: 1 results,  Invited: 1 results)

  • [Journal Article] Prediction of the initiation of cerebral aneurysms2016

    • Author(s)
      Kuniyasu Niizuma, Takanobu Yagi, Shin-ichiro Sugiyama, Atsuhiro Nakagawa, and Teiji Tominaga
    • Journal Title

      The 2nd International Symposium on Multidisciplinary Computational Anatomy

      Volume: -

    • Related Report
      2015 Annual Research Report
    • Acknowledgement Compliant
  • [Journal Article] 脳動脈瘤壁の硬化性変化2014

    • Author(s)
      新妻邦泰、杉山慎一郎、遠藤英徳、松本康史、冨永悌二
    • Journal Title

      脳神経外科速報

      Volume: 24 Pages: 640-643

    • Related Report
      2014 Annual Research Report
  • [Journal Article] Relative residence time prolongation in intracranial aneurysms: a possible association with atherosclerosis.2013

    • Author(s)
      Sugiyama S, Niizuma K, Nakayama T, Shimizu H, Endo H, Inoue T, Fujimura M, Ohta M, Takahashi A, Tominaga T.
    • Journal Title

      Neurosurgery

      Volume: 73 Issue: 5 Pages: 767-776

    • DOI

      10.1227/neu.0000000000000096

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Presentation] Bifurcation configuration as a criterion affecting risk of aneurysm rupture in Basilar artery aneurysms2016

    • Author(s)
      Sherif Rashad, Shin-ichiro Sugiyama, Kuniyasu Niizuma, Kenichi Sato, Hidenori Endo, Yasushi Matsumoto, Miki Fujimura, Teiji Tominaga
    • Organizer
      European congress on computational methods in applied sciences and engineering
    • Place of Presentation
      Greece
    • Year and Date
      2016-06-05
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] The CFD rupture challenge 2013: Prediction of rupture status in intracranial aneurysms2016

    • Author(s)
      杉山慎一郎, 新妻邦泰, 遠藤英徳, 佐藤健一, 松本康史, 船本健一, 太田信, 冨永悌二
    • Organizer
      第38回日本脳神経CI学会
    • Place of Presentation
      名古屋
    • Year and Date
      2016-02-13
    • Related Report
      2015 Annual Research Report
  • [Presentation] 脳疾患領域におけるComputational Fluid Dynamics: 最新の知見2015

    • Author(s)
      新妻邦泰、杉山慎一郎、遠藤英徳、佐藤健一、藤村幹、松本康史、冨永悌二
    • Organizer
      2015-02-25_SENDAI 脳・心血管疾患 JOINT Symposium 2015
    • Place of Presentation
      江陽グランドホテル(宮城県仙台市)
    • Year and Date
      2015-02-25
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] 破裂瘤の治療後早期に破裂した前交通動脈瘤の一例  ー 血行力学的変化の検討 ー2014

    • Author(s)
      新妻邦泰、杉山慎一郎、遠藤英徳、佐藤健一、松本康史、藤村幹、冨永悌二
    • Organizer
      第26回日本脳循環代謝学会
    • Place of Presentation
      岡山コンベンションセンター(岡山県岡山市)
    • Year and Date
      2014-11-21 – 2014-11-22
    • Related Report
      2014 Annual Research Report
  • [Presentation] A Case of Anterior Communicating Artery Aneurysm Ruptured after the Treatment of Another Ruptured Aneurysm2014

    • Author(s)
      Niizuma K, Sugiyama S, Endo H, Sato K, Matsumoto Y, Fujimura M, Tominaga T
    • Organizer
      Asia Pacific Stroke Conference 2014
    • Place of Presentation
      台北(台湾)
    • Year and Date
      2014-09-12 – 2014-09-14
    • Related Report
      2014 Annual Research Report
  • [Presentation] 脳動脈瘤に対する数値流体力学的アプローチ2014

    • Author(s)
      新妻邦泰、杉山慎一郎、遠藤英徳、清水宏明、藤村幹、井上敬、近藤竜史、松本康史、船本健一、冨永悌二
    • Organizer
      第43回日本脳卒中の外科学会学術総会
    • Place of Presentation
      大阪
    • Related Report
      2013 Annual Research Report
  • [Presentation] CFD解析による脳動脈瘤壁性状の予測2013

    • Author(s)
      新妻邦泰、杉山慎一郎、遠藤英徳、清水宏明、近藤竜史、松本康史、長嶺義秀、藤原悟、冨永悌二
    • Organizer
      第22回日本脳ドック学会総会
    • Place of Presentation
      仙台
    • Related Report
      2013 Annual Research Report
  • [Presentation] 破裂瘤の治療後早期に破裂した前交通動脈瘤の一例  ー 血行力学的変化の検討 ー2013

    • Author(s)
      新妻邦泰、杉山慎一郎、遠藤英徳、鈴木一郎、近藤竜史、松本康史、冨永悌二
    • Organizer
      第29回日本脳神経血管内治療学会学術総会
    • Place of Presentation
      新潟
    • Related Report
      2013 Annual Research Report
  • [Presentation] Stagnant Blood Flow in Intracranial Aneurysms2013

    • Author(s)
      Shin-ichiro Sugiyama, Kuniyasu Niizuma, Kenichi Funamoto, Toshio Nakayama, TeijiTominaga
    • Organizer
      ICBME 2013
    • Place of Presentation
      Singapore, Singapore
    • Related Report
      2013 Annual Research Report

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Published: 2013-05-21   Modified: 2019-07-29  

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