| Budget Amount *help |
¥23,660,000 (Direct Cost: ¥18,200,000、Indirect Cost: ¥5,460,000)
Fiscal Year 2015: ¥7,800,000 (Direct Cost: ¥6,000,000、Indirect Cost: ¥1,800,000)
Fiscal Year 2014: ¥6,890,000 (Direct Cost: ¥5,300,000、Indirect Cost: ¥1,590,000)
Fiscal Year 2013: ¥8,970,000 (Direct Cost: ¥6,900,000、Indirect Cost: ¥2,070,000)
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| Outline of Final Research Achievements |
The transplantation of neural stem/precursor cells (NSPCs) is a promising therapeutic strategy for spinal cord injury (SCI) , however, few studies have investigated NSPC transplantation for the severe injury nor chronic phase of SCI, and its therapeutic efficacy remains controversial. In this study, we demonstrated that the interactive synaptic reorganization between engrafted NSPCs and spared host neurons is crucial for functional recovery. In addition, even with the adequate capacity in generating neurons/oligodendrocytes and producing therapeutic molecules, engrafted NSPCs did not improve locomotor function, indicating that failure in chronic transplantation is not due to the lack of therapeutic activities of engrafted NSPCs but the refractory state of chronically injured spinal cords. Environmental modulation, rather modification of transplanting cells, will be significant for successful translation of stem cell-based therapies for SCI.
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