| Budget Amount *help |
¥17,160,000 (Direct Cost: ¥13,200,000、Indirect Cost: ¥3,960,000)
Fiscal Year 2016: ¥3,510,000 (Direct Cost: ¥2,700,000、Indirect Cost: ¥810,000)
Fiscal Year 2015: ¥3,510,000 (Direct Cost: ¥2,700,000、Indirect Cost: ¥810,000)
Fiscal Year 2014: ¥3,510,000 (Direct Cost: ¥2,700,000、Indirect Cost: ¥810,000)
Fiscal Year 2013: ¥6,630,000 (Direct Cost: ¥5,100,000、Indirect Cost: ¥1,530,000)
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| Outline of Final Research Achievements |
Lymphatic vessels are known to be induced with angiogenesis in various diseases. We reported that typical lymphatic vessels were not induced in choroidal neovascularization which is often observed in age-related macular degeneration. In addition, macrophages are important for lymphangiogenesis. Our study revealed M2 macrophages are important in choroidal neovascularization. Furthermore, we reported M2 macrophages predominates with age, and that ROCK2 is the molecular target. Furthermore, we examined if lymphatic vessel could be induced during retinal neovascularization model, but Lyve-1 podoplanin positive lymphatics could not be observed. Lyve1 expression was elevated in the model and the expression could be observed in macrophages.
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