New therapeutic strategies targeting lymphatic vessels for retinochoroidal disease
| Project/Area Number |
25713057
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| Research Category |
Grant-in-Aid for Young Scientists (A)
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| Allocation Type | Partial Multi-year Fund |
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| Research Field |
Ophthalmology
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| Research Institution | Kyushu University |
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Principal Investigator |
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| Project Period (FY) |
2013-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥17,160,000 (Direct Cost: ¥13,200,000、Indirect Cost: ¥3,960,000)
Fiscal Year 2016: ¥3,510,000 (Direct Cost: ¥2,700,000、Indirect Cost: ¥810,000)
Fiscal Year 2015: ¥3,510,000 (Direct Cost: ¥2,700,000、Indirect Cost: ¥810,000)
Fiscal Year 2014: ¥3,510,000 (Direct Cost: ¥2,700,000、Indirect Cost: ¥810,000)
Fiscal Year 2013: ¥6,630,000 (Direct Cost: ¥5,100,000、Indirect Cost: ¥1,530,000)
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| Keywords | 血管新生 / リンパ管新生 / 糖尿病網膜症 / VEGF / 網膜 / 脈絡膜 / イメージング / モデル動物 |
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| Outline of Final Research Achievements |
Lymphatic vessels are known to be induced with angiogenesis in various diseases. We reported that typical lymphatic vessels were not induced in choroidal neovascularization which is often observed in age-related macular degeneration. In addition, macrophages are important for lymphangiogenesis. Our study revealed M2 macrophages are important in choroidal neovascularization. Furthermore, we reported M2 macrophages predominates with age, and that ROCK2 is the molecular target. Furthermore, we examined if lymphatic vessel could be induced during retinal neovascularization model, but Lyve-1 podoplanin positive lymphatics could not be observed. Lyve1 expression was elevated in the model and the expression could be observed in macrophages.
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Report
(5 results)
Research Products
(15 results)
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[Journal Article] High-Resolution Imaging by Adaptive Optics Scanning Laser Ophthalmoscopy Reveals Two Morphologically Distinct Types of Retinal Hard Exudates.2016
Author(s)
Yamaguchi M, Nakao S, Kaizu Y, Kobayashi Y, Nakama T, Arima M, Yoshida S, Oshima Y, Takeda A, Ikeda Y, Mukai S, Ishibashi T, Sonoda KH.
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Journal Title
Sci Rep.
Volume: 6
Issue: 1
Pages: 33574-33574
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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[Journal Article] Vascular Normalization by ROCK Inhibitor: Therapeutic Potential of Ripasudil (K-115) Eye Drop in Retinal Angiogenesis and Hypoxia.2016
Author(s)
Yamaguchi M, Nakao S, Arita R, Kaizu Y, Arima M, Zhou Y, Kita T, Yoshida S, Kimura K, Isobe T, Kaneko Y, Sonoda KH, Ishibashi T.
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Journal Title
Invest Ophthalmol Vis Sci
Volume: 57
Issue: 4
Pages: 2264-2276
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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[Journal Article] ROCK-Isoform-Specific Polarization of Macrophages Associated with Age-Related Macular Degeneration2015
Author(s)
Zandi S, Nakao S, Chun K H, Fiorina P, Sun D, Arita R, Zhao M, Kim E, Schueller O, Campbell S, Taher M, Melhorn M I, Schering A, Gatti F, Tezza S, Xie F, Vergani A, Yoshida S, Ishikawa K, Yamaguchi M, Sasaki F, Schmidt-Ullrich R, Hata Y, Enaida H, Yuzawa M, Yokomizo T, 4名
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Journal Title
Cell Rep
Volume: 10
Issue: 7
Pages: 1173-86
DOI
Related Report
Peer Reviewed / Open Access
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[Presentation] Therapeutic potential of topical ROCK inhibitor Ripasudil (K-115) in choroidal neovascularization2016
Author(s)
Yamaguchi M, Nakao S, Kaizu Y, Kobayashi Y, Nakama T, Yoshida S,Oshima Y, Isobe T, Kaneko Y, Ishibashi T, Sonoda KH
Organizer
The Association for Research in Vision and Ophthalmology
Place of Presentation
Seattle
Year and Date
2016-05-01
Related Report
Int'l Joint Research
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