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Strategy to improve the quality of wound angiogenesis

Research Project

Project/Area Number 25713059
Research Category

Grant-in-Aid for Young Scientists (A)

Allocation TypePartial Multi-year Fund
Research Field Plastic surgery
Research InstitutionKeio University

Principal Investigator

Kubota Yoshiaki  慶應義塾大学, 医学部, 教授 (50348687)

Project Period (FY) 2013-04-01 – 2017-03-31
Project Status Completed (Fiscal Year 2016)
Budget Amount *help
¥25,220,000 (Direct Cost: ¥19,400,000、Indirect Cost: ¥5,820,000)
Fiscal Year 2016: ¥5,720,000 (Direct Cost: ¥4,400,000、Indirect Cost: ¥1,320,000)
Fiscal Year 2015: ¥5,720,000 (Direct Cost: ¥4,400,000、Indirect Cost: ¥1,320,000)
Fiscal Year 2014: ¥5,720,000 (Direct Cost: ¥4,400,000、Indirect Cost: ¥1,320,000)
Fiscal Year 2013: ¥8,060,000 (Direct Cost: ¥6,200,000、Indirect Cost: ¥1,860,000)
Keywords血管 / 創傷治癒 / VEGF / VEGFR2 / 発現制御 / 発生・分化 / 循環器・高血圧 / 血管新生 / 細胞・組織 / 臨床
Outline of Final Research Achievements

Once skin tissues are injured, the endogenous healing program takes place and damaged tissues are repaired or regenerated. Angiogenesis, formation of new blood vessels from nascent vessels, are believed to play a central role in this repairing process. However, the entity of the kinetics of blood vessels associated with wound healing is only ambiguously clarified. Here we established a new wound healing model using neonatal mice, suitable for visualizing the 3-D structure of blood vessels in wound tissues. Utilizing this technique, we found vascular changes during wound repair are mainly the vascular enlargement accompanied by increased blood flow, and the vessel curving caused by wound contraction, rather than typical angiogenesis. We also found the increase in diameter and blood flow depends on the VEGF-VEGFR2 signaling. These results suggest the vascular remodeling during wound healing is not a typical angiogenesis, but uniquely characterized as enlargement and curving.

Report

(5 results)
  • 2016 Annual Research Report   Final Research Report ( PDF )
  • 2015 Annual Research Report
  • 2014 Annual Research Report
  • 2013 Annual Research Report
  • Research Products

    (24 results)

All 2017 2015 2014 2013 Other

All Int'l Joint Research (5 results) Journal Article (5 results) (of which Int'l Joint Research: 4 results,  Peer Reviewed: 5 results,  Open Access: 4 results,  Acknowledgement Compliant: 1 results) Presentation (13 results) (of which Int'l Joint Research: 2 results,  Invited: 13 results) Remarks (1 results)

  • [Int'l Joint Research] Max Planck Institute of Neurobiology(ドイツ)

    • Related Report
      2016 Annual Research Report
  • [Int'l Joint Research] Sichuan Academy of Medical Sciences(中国)

    • Related Report
      2016 Annual Research Report
  • [Int'l Joint Research] The University of Texas Southwestern/National Institutes of Health/University of Minnesota(米国)

    • Related Report
      2016 Annual Research Report
  • [Int'l Joint Research] Natinal Institutes of Health(米国)

    • Related Report
      2015 Annual Research Report
  • [Int'l Joint Research] University of Minnesota(米国)

    • Related Report
      2015 Annual Research Report
  • [Journal Article] Plastic roles of pericytes in the blood retinal barrier.2017

    • Author(s)
      Park DY, Lee J, Kim J, Kim K, Hong S, Han S, Kubota Y, Augustin HG, Morrison SJ, Kim JW, DePinho RA, He Y, Adams RH and Koh GY
    • Journal Title

      Nature Communications

      Volume: 印刷中

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Tissue Myeloid Progenitors Differentiate into Pericytes through TGF-β Signaling in Developing Skin Vasculature.2017

    • Author(s)
      Yamazaki T, Nalbandian A, Uchida Y, Li W, Arnold TD, Kubota Y, Yamamoto S, Ema M, Mukouyama YS
    • Journal Title

      Cell Reports

      Volume: 18 Issue: 12 Pages: 2991-3004

    • DOI

      10.1016/j.celrep.2017.02.069

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] VEGFR2 but not VEGFR3 governs integrity and remodeling of thyroid angiofollicular unit in normal state and during goitrogenesis.2017

    • Author(s)
      Jang JY, Choi SY, Park I, Park DY, Choe K, Kim P, Kim YK, Lee BJ, Hirashima M, Kubota Y, Park JW, Cheng SY, Nagy A, Park YJ, Alitalo K, Shong M and Koh GY
    • Journal Title

      EMBO Molecular Medicine

      Volume: 印刷中

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Osteogenic capillaries orchestrate growth plate-independent ossification of the malleus2015

    • Author(s)
      Matsuo K, Kuroda Y, Nango N, Shimoda K, Kubota Y, Ema M, Bakiri L, Wagner EF, Takeda Y, Yashiro W, Momose A
    • Journal Title

      Development

      Volume: 142 Pages: 3912-20

    • DOI

      10.1242/dev.123885

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Unveiling Angptl2, a rising HSC expander.2014

    • Author(s)
      Yoshiaki Kubota
    • Journal Title

      Blood

      Volume: 124 Pages: 833-834

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed
  • [Presentation] 網膜発生における血管―神経のクロストーク2017

    • Author(s)
      久保田義顕
    • Organizer
      第121回日本解剖学会総会シンポジウム
    • Place of Presentation
      長崎大学坂本キャンパス (長崎県長崎市)
    • Year and Date
      2017-03-29
    • Related Report
      2016 Annual Research Report
    • Invited
  • [Presentation] 血管新生におけるミクログリアの役割2017

    • Author(s)
      久保田義顕
    • Organizer
      第42回日本微小循環学会総会
    • Place of Presentation
      富山国際会議場 (富山県富山市)
    • Year and Date
      2017-03-26
    • Related Report
      2016 Annual Research Report
    • Invited
  • [Presentation] Organ-specific vascular morphogenesis.2017

    • Author(s)
      Yoshiaki Kubota
    • Organizer
      Keio-NUS symposium on Life Cycle Medicine
    • Place of Presentation
      National University of Singapore (Singapore)
    • Year and Date
      2017-01-10
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Neurons limit angiogenesis by titrating VEGF in retina.2015

    • Author(s)
      久保田義顕
    • Organizer
      第11回麒麟塾
    • Place of Presentation
      コクヨホール(東京都港区)
    • Year and Date
      2015-07-11
    • Related Report
      2015 Annual Research Report
    • Invited
  • [Presentation] 血管ネットワーク形成のメカニズム2015

    • Author(s)
      久保田義顕
    • Organizer
      第31回慶應義塾大学形成外科同門会学術集会
    • Place of Presentation
      慶應義塾大学信濃町キャンパス(東京都新宿区)
    • Year and Date
      2015-07-11
    • Related Report
      2015 Annual Research Report
    • Invited
  • [Presentation] 中枢神経系における血管の発生2015

    • Author(s)
      久保田義顕
    • Organizer
      第33回内分泌学会サマーセミナー
    • Place of Presentation
      柳川藩主立花邸御花(福岡県柳川市)
    • Year and Date
      2015-07-09
    • Related Report
      2015 Annual Research Report
    • Invited
  • [Presentation] 網膜血管パターニングの制御機構2015

    • Author(s)
      久保田義顕
    • Organizer
      Research PlaNet 2015
    • Place of Presentation
      梅田スカイビルタワーウエスト(大阪府大阪市)
    • Year and Date
      2015-06-20
    • Related Report
      2015 Annual Research Report
    • Invited
  • [Presentation] Neuronal VEGF endocytosis triggers the programmed regression of hyaloid vessels2015

    • Author(s)
      久保田義顕
    • Organizer
      秋期特別日本血管生物医学会シンポジウム
    • Place of Presentation
      大阪大学微生物学研究所(大阪府吹田市)
    • Year and Date
      2015-05-13
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] 網膜血管発生と病的血管新生2014

    • Author(s)
      久保田義顕
    • Organizer
      第12回心臓血管発生研究会
    • Place of Presentation
      磐梯熱海温泉 ホテル 華の湯(福島県郡山市)
    • Year and Date
      2014-10-17 – 2014-10-18
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] Paracrine interplay between neural and vascular systems in the retina.2014

    • Author(s)
      久保田義顕
    • Organizer
      Lecture in Biomedicum Helsinki
    • Place of Presentation
      University of Helsinki (Helsinki, Finland)
    • Year and Date
      2014-10-10 – 2014-10-12
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] 血管新生におけるマクロファージの役割2014

    • Author(s)
      久保田義顕
    • Organizer
      第36回日本血栓止血学会学術集会
    • Place of Presentation
      大阪国際交流センター(大阪府天王寺区上本町)
    • Year and Date
      2014-05-29 – 2014-05-31
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] 腫瘍血管特異的な血管新生分子メカニズム2013

    • Author(s)
      久保田義顕
    • Organizer
      第4回Molecular Cardiovascular Conference II
    • Place of Presentation
      北海道キロロ
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] 腫瘍血管特異的分子標的としての酸化ストレスシグナル2013

    • Author(s)
      久保田義顕
    • Organizer
      第21回日本血管生物医学会学術集会
    • Place of Presentation
      大阪千里阪急
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Remarks] 研究室ホームページ

    • URL

      http://www.keiovascular.com/

    • Related Report
      2015 Annual Research Report 2014 Annual Research Report

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Published: 2013-05-21   Modified: 2022-02-16  

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