Strategy to improve the quality of wound angiogenesis
| Project/Area Number |
25713059
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| Research Category |
Grant-in-Aid for Young Scientists (A)
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| Allocation Type | Partial Multi-year Fund |
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| Research Field |
Plastic surgery
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| Research Institution | Keio University |
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Principal Investigator |
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| Project Period (FY) |
2013-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥25,220,000 (Direct Cost: ¥19,400,000、Indirect Cost: ¥5,820,000)
Fiscal Year 2016: ¥5,720,000 (Direct Cost: ¥4,400,000、Indirect Cost: ¥1,320,000)
Fiscal Year 2015: ¥5,720,000 (Direct Cost: ¥4,400,000、Indirect Cost: ¥1,320,000)
Fiscal Year 2014: ¥5,720,000 (Direct Cost: ¥4,400,000、Indirect Cost: ¥1,320,000)
Fiscal Year 2013: ¥8,060,000 (Direct Cost: ¥6,200,000、Indirect Cost: ¥1,860,000)
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| Keywords | 血管 / 創傷治癒 / VEGF / VEGFR2 / 発現制御 / 発生・分化 / 循環器・高血圧 / 血管新生 / 細胞・組織 / 臨床 |
|---|
| Outline of Final Research Achievements |
Once skin tissues are injured, the endogenous healing program takes place and damaged tissues are repaired or regenerated. Angiogenesis, formation of new blood vessels from nascent vessels, are believed to play a central role in this repairing process. However, the entity of the kinetics of blood vessels associated with wound healing is only ambiguously clarified. Here we established a new wound healing model using neonatal mice, suitable for visualizing the 3-D structure of blood vessels in wound tissues. Utilizing this technique, we found vascular changes during wound repair are mainly the vascular enlargement accompanied by increased blood flow, and the vessel curving caused by wound contraction, rather than typical angiogenesis. We also found the increase in diameter and blood flow depends on the VEGF-VEGFR2 signaling. These results suggest the vascular remodeling during wound healing is not a typical angiogenesis, but uniquely characterized as enlargement and curving.
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Report
(5 results)
Research Products
(24 results)
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[Journal Article] Plastic roles of pericytes in the blood retinal barrier.2017
Author(s)
Park DY, Lee J, Kim J, Kim K, Hong S, Han S, Kubota Y, Augustin HG, Morrison SJ, Kim JW, DePinho RA, He Y, Adams RH and Koh GY
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Journal Title
Nature Communications
Volume: 印刷中
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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[Journal Article] VEGFR2 but not VEGFR3 governs integrity and remodeling of thyroid angiofollicular unit in normal state and during goitrogenesis.2017
Author(s)
Jang JY, Choi SY, Park I, Park DY, Choe K, Kim P, Kim YK, Lee BJ, Hirashima M, Kubota Y, Park JW, Cheng SY, Nagy A, Park YJ, Alitalo K, Shong M and Koh GY
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Journal Title
EMBO Molecular Medicine
Volume: 印刷中
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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[Journal Article] Osteogenic capillaries orchestrate growth plate-independent ossification of the malleus2015
Author(s)
Matsuo K, Kuroda Y, Nango N, Shimoda K, Kubota Y, Ema M, Bakiri L, Wagner EF, Takeda Y, Yashiro W, Momose A
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Journal Title
Development
Volume: 142
Pages: 3912-20
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
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[Presentation] 網膜血管パターニングの制御機構2015
Author(s)
久保田義顕
Organizer
Research PlaNet 2015
Place of Presentation
梅田スカイビルタワーウエスト（大阪府大阪市）
Year and Date
2015-06-20
Related Report
Invited
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[Presentation] 網膜血管発生と病的血管新生2014
Author(s)
久保田義顕
Organizer
第12回心臓血管発生研究会
Place of Presentation
磐梯熱海温泉 ホテル 華の湯（福島県郡山市）
Year and Date
2014-10-17 – 2014-10-18
Related Report
Invited
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