Identification and functional analysis of target microRNAs of angiogenesis factor regulating endochondral ossification
| Project/Area Number |
25713064
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| Research Category |
Grant-in-Aid for Young Scientists (A)
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| Allocation Type | Partial Multi-year Fund |
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| Research Field |
Orthodontics/Pediatric dentistry
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| Research Institution | Kyushu Dental College |
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Principal Investigator |
FUJITA Yuko 九州歯科大学, 歯学部, 助教 (90514670)
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| Project Period (FY) |
2013-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥24,960,000 (Direct Cost: ¥19,200,000、Indirect Cost: ¥5,760,000)
Fiscal Year 2016: ¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2015: ¥6,760,000 (Direct Cost: ¥5,200,000、Indirect Cost: ¥1,560,000)
Fiscal Year 2014: ¥6,500,000 (Direct Cost: ¥5,000,000、Indirect Cost: ¥1,500,000)
Fiscal Year 2013: ¥6,630,000 (Direct Cost: ¥5,100,000、Indirect Cost: ¥1,530,000)
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| Keywords | マイクロRNA / 血管新生 / 骨化 / マイクロアレイ / 咬筋 / 統合解析 / マイクロＲＮＡ / 成長発育 / ラット / 軟骨内骨化 / 骨形成 / 骨代謝 / microRNA |
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| Outline of Final Research Achievements |
We performed microarray and integrated analyses of microRNA-mRNA expression profiles for masseter muscle in rats fed the soft or hard diets. In addition, we identified the miRNAs and mRNAs associated with the angiogenesis and endochondral ossification using Gene Ontology (GO) analysis.
GO analysis predicted interactions between 12 genes and 8 miRNAs, including some angiogenesis factors and ossification genes. In particular, 5 mRNAs associated with angiogenesis and endochondral ossification were identified as potential targets of rno-miR-19b-3p and rno-miR-181c-5p, respectively.
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Report
(5 results)
Research Products
(10 results)
