| Budget Amount *help |
¥3,380,000 (Direct Cost: ¥2,600,000、Indirect Cost: ¥780,000)
Fiscal Year 2015: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2014: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2013: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
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| Outline of Final Research Achievements |
To carry "personalized medicine" for patients, that is, to conduct more effective medical treatments according to individual patient's characteristics, we should consider the set of treatment regimes (treatment strategy) that is based on patient's time-dependent biomarkers during clinical practice. In this study, I focused on "dynamic treatment regimes" that are defined as adaptive treatment strategies based on the patient's time-varying characteristics, and to estimate the appropriate levels of the biomarkers to be targeted in the regimes. In particular, I have utilized, extended, and statistically evaluated the following causal-inference methods: 1) marginal structural models, 2) structural nested models, and 3) the parametric g-computation algorithm.
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