Synthetic biological approach to construct and analyze a synthetic microbial ecosystem
Project/Area Number |
25730176
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Research Category |
Grant-in-Aid for Young Scientists (B)
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Allocation Type | Multi-year Fund |
Research Field |
Life / Health / Medical informatics
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Research Institution | Tokyo Institute of Technology |
Principal Investigator |
Ayukawa Shotaro 東京工業大学, 情報生命博士教育院, 特任助教 (70645845)
|
Project Period (FY) |
2013-04-01 – 2016-03-31
|
Project Status |
Completed (Fiscal Year 2015)
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Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2014: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2013: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
|
Keywords | 人工遺伝子回路 / 微生物共生系 / 合成生物学 |
Outline of Final Research Achievements |
Many microbes are living by forming symbiotic systems that have complex structures and functions by communicating with other microbes. In order to understand the design principle of these symbiotic systems, we constructed a synthetic mutualistic system that is easy to be controlled and analyzed with the synthetic biological approach. Firstly, we designed and constructed synthetic genetic circuits that make E.coli cells to form a mutualistic system in which two types of cells help the other’s survival by inducing expression of antibiotic resistance genes through cell-cell communication molecules. Furthermore, we confirmed that the synthetic mutualistic system can exist stably with culture experiments and numerical simulations.
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Report
(4 results)
Research Products
(5 results)
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[Presentation] 共生系への合成生物学的アプローチ2014
Author(s)
西田暁史, 鮎川翔太郎, 山村雅幸
Organizer
環境微生物系学会合同大会
Place of Presentation
アクトシティ浜松コングレスセンター
Year and Date
2014-10-21 – 2014-10-24
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