| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2015: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2014: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2013: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
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| Outline of Final Research Achievements |
Ionizing radiation induces genetic instability in the progeny of the irradiated cells, that is estimated to be involved in radiation carcinogenesis. To clarify the mechanism of genetic instability is a very important because even lead to the elucidation of carcinogenic processes not only the biological effects of radiation. In this study, we hypothesized that some of the non-DSB type of DNA damage remaining after DSB repair may be related to the induction of genetic instability. As one of the causes that induce genetic instability, it was focused on the type of non-DSB damage. Then, we analyzed using delayed chromosomal aberrations and karyotype in order to clarify the differences in the genetic instability induced by the type of difference in damage.
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