Effects on alleviation of lipid metabolism abnormality and arteriosclerotic lesion by voluntary exercise and dietary environment
| Project/Area Number |
25750035
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Eating habits
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| Research Institution | Tohoku University |
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Principal Investigator |
INOUE NAO 東北大学, (連合)農学研究科(研究院), 助教 (90510529)
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| Project Period (FY) |
2013-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2014: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2013: ¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
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| Keywords | 脂質代謝 / 糖代謝 / エネルギー代謝 / 食品 / メタボリックシンドローム / 耐糖能 / 食事療法 / 運動療法 |
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| Outline of Final Research Achievements |
We evaluated the effect of "dietary component A" on prevention of lipid accumulation and inflammation by hepatocyte, myocyte and lipocyte derived from mouse. However, "dietary component A" induced apoptosis in long-term cell culture. Additionally, we evaluated the effects of "dietary component A" on lipid metabolism, carbohydrate metabolism and energy metabolism in mice. First, we evaluated by single oral administration. In the result, carbohydrate consumption, fat consumption and lipid parameters were the same between the groups. Second, we evaluated as the diets including "dietary component A" in short-term feeding or long-term feeding. As the result of respiratory gas analysis, carbohydrate consumption was higher by the feeding of "dietary component A". Furthermore, Serum glucose level, the hepatic TAG level and the inflammation marker levels in muscle and WAT were significantly lower by the feeding of "dietary component A".
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Report
(3 results)
Research Products
(25 results)
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[Journal Article] A comparison of the lipid-lowering effects of four different n-3 highly unsaturated fatty acids in HepG2 cells.2015
Author(s)
K. Yoshinaga, K. Sasaki, H. Watanabe, K. Nagao, N. Inoue, B. Shirouchi, T. Yanagita, T. Nagai, H. Mizobe, K. Kojima, F. Beppu, N. Gotoh
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Journal Title
J. Nutr. Biochem.
Volume: 26
Issue: 1
Pages: 57-63
DOI
NAID
Related Report
Peer Reviewed / Acknowledgement Compliant
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[Journal Article] Epigallocatechin gallate decreases the micellar solubility of cholesterol via specific interaction with phosphatidylcholine.2014
Author(s)
Kobayashi M, Nishizawa M, Inoue N, Hosoya T, Yoshida M, Ukawa Y, Sagesaka YM, Doi T, Nakayama T, Kumazawa S, Ikeda I.
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Journal Title
Journal of Agricultural and Food Chemistry
Volume: 62
Issue: 13
Pages: 2881-2890
DOI
Related Report
Peer Reviewed
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[Journal Article] Oxytocin Receptor in the Hypothalamus Is Sufficient to Rescue Normal Thermoregulatory Function in Male Oxytocin Receptor Knockout Mice.2013
Author(s)
Kasahara Y, Sato K, Takayanagi Y, Mizukami H, Ozawa K, Hidema S, So K-H, Kawada T, Inoue N, Ikeda I, Roh S-G, Itoi K, and Nishimori
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Journal Title
Endocrinology
Volume: 154
Issue: 11
Pages: 4305-4315
DOI
Related Report
Peer Reviewed
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