Impact of maternal BMI and dietary intake on health of mother and child.

• Project/Area Number: 25750036
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Eating habits
• Research Institution: Yamanashi Gakuin University
• Principal Investigator: YACHI Yoko 山梨学院大学, 健康栄養学部, 講師 (30642821)
• Project Period (FY): 2013-04-01 – 2015-03-31
• Project Status: Completed (Fiscal Year 2014)
• Budget Amount: ¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000); Fiscal Year 2014: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2013: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
• Keywords: 若年女性のやせ / 低出生体重児 / 妊産婦の栄養 / BMI / 血糖値 / 妊娠糖尿病

Outline of Final Research Achievements

Birth weight is known to affect not only perinatal health or subsequent growth/development but also morbidity in later life. Especially low birth weight (LBW) is now recognized as an established risk for future metabolic abnormalities, including obesity and diabetes. Although it is well known that hyperglycemia is an important risk factor for macrosomia, whether maternal glucose levels are associated with incident neonatal LBW is unknown. We therefore examined the associations between maternal glycemia within normal glucose tolerance and the risk of LBW infants in Japanese mothers. In addition, we examined the relative contributions of maternal glycemia and BMI to LBW.
In this study, a low 1-h postload glucose level but within normal range and low maternal BMI alone, as well as in combination, were independently associated with an increased risk of incident LBW independent of other known risk factors. Their combination had a greater impact than either value alone.

Research Products

• [Journal Article] 妊婦の糖代謝 (2015)
  • Author(s): 谷内洋子、曽根博仁
  • Journal Title: bios Volume: 20 Pages: 3-6
  • Peer Reviewed
• [Journal Article] 妊娠中の母体血糖状態と低出生体重児出産 (2015)
  • Author(s): 谷内洋子、曽根博仁
  • Journal Title: 糖尿病と妊娠 Volume: 15
  • NAID: 40020585166
  • Peer Reviewed
• [Journal Article] 日本人女性の妊娠前後の体型および栄養摂取が母児の健康に及ぼす影響の検証 (2014)
  • Author(s): 谷内 洋子
  • Journal Title: 栄養学雑誌 Volume: 72 Pages: 47-48
  • Peer Reviewed
• [Journal Article] High Risk of Failing Eradication of Helicobacter Pylori in Patients with Diabetes: A Meta-analysis (2014)
  • Author(s): Horikawa C, Kodama S, Fujihara K, Hirasawa R, Yachi Y, Suzuki A, Hanyu O, Shimano H, Sone H
  • Journal Title: Diabet Res Clin Prac Volume: 106 Issue: 1 Pages: 81-7
  • DOI: 10.1016/j.diabres.2014.07.009
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Meta-analysis of the quantitative relation between pulse pressure and mean arterial pressure and cardiovascular risk in patients with diabetes mellitus. (2014)
  • Author(s): Kodama S, Horikawa C, Fujihara K, Yoshizawa S, Yachi Y, Tanaka S, Ohara N, Matsunaga S, Yamada T, Hanyu O, Sone H.
  • Journal Title: The American Journal of Cardiology Volume: 113 Issue: 6 Pages: 1058-1065
  • DOI: 10.1016/j.amjcard.2013.12.005
  • Peer Reviewed
• [Journal Article] Association of Helicobacter Pylori Infection with Glycemic Control in Patients with Diabetes: A Meta-analysis (2014)
  • Author(s): Horikawa C, Kodama S, Fujihara K, Yachi Y, Tanaka S, Suzuki A, Hanyu O, Shimano H, Sone H
  • Journal Title: J Diab Res Volume: - Pages: 250620-250620
  • DOI: 10.1155/2014/250620
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Second trimester postload glucose level as an important predictor of low birth weight infants: Tanaka Women's Clinic Study (2014)
  • Author(s): Yachi Y, Tanaka Y, Nishibata I, Yoshizawa S, Fujihara K, Kodama S, Suzuki A, Hanyu O, Sone H
  • Journal Title: Diabetes Res Clin Pract Volume: 105 Issue: 3 Pages: e16-e19
  • DOI: 10.1016/j.diabres.2014.02.006
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] High cholesterol intake is associated with elevated risk of type 2 diabetes mellitus - a meta-analysis. (2014)
  • Author(s): Tajima R, Kodama S, Hirata M, Horikawa C, Fujihara K, Yachi Y, Yoshizawa S, Iida KT, Sone H.
  • Journal Title: Clinical Nutrition Volume: 33 (6) Issue: 6 Pages: 946-50
  • DOI: 10.1016/j.clnu.2014.03.001
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] 健常妊婦における栄養と妊娠経過に関する中間解析. (2013)
  • Author(s): 谷内洋子、曽根博仁
  • Journal Title: 栄養学雑誌 Volume: 71 Pages: 242-252
  • NAID: 130004553519
  • Peer Reviewed
• [Journal Article] Diabetes and risk of hearing impairment in adults: a meta-analysis (2013)
  • Author(s): Horikawa C, Kodama S, Tanaka S, Fujihara K, Hirasawa R, Yachi Y, Shimano H, Yamada N, Saito K, Sone H
  • Journal Title: J Clin EndocrinoI Metab Volume: 98(1) Issue: 1 Pages: 51-58
  • DOI: 10.1210/jc.2012-2119
  • Peer Reviewed
• [Journal Article] Body Weight Change and Type 2 Diabetes (2013)
  • Author(s): Kodama S, Horikawa C, Yoshizawa S, Fujihara K, Yachi Y, Tanaka S, Suzuki A, Hanyu O, Yagyu H, Sone H
  • Journal Title: Epidemiology Volume: 24 Issue: 5 Pages: 778-9
  • DOI: 10.1097/ede.0b013e31829f6c31
  • Peer Reviewed
• [Journal Article] Use of high-normal levels of hemoglobin A1C and fasting plasma glucose for diabetes screening and prediction - A meta-analysis (2013)
  • Author(s): Kodama S, Horikawa C, Fujihara K, Hirasawa R, Yachi Y, Yoshizawa S, Tanaka S, Sone Y, Shimano H, Iida KT, Saito K, Sone H
  • Journal Title: Diabetes Metab Res Rev Volume: 29 Issue: 8 Pages: 680-92
  • DOI: 10.1002/dmrr.2445
  • Peer Reviewed
• [Journal Article] Quality and accuracy of Internet information concerning a healthy diet (2013)
  • Author(s): Hirasawa R, Yachi Y, Yoshizawa S, Horikawa C, Heianza Y, Sugawara A, Sone Y, Kondo K, Shimano H, Saito K, Kodama S, Sone H.
  • Journal Title: Int J Food Sci Nutr Volume: 64 Issue: 8 Pages: 1007-1013
  • DOI: 10.3109/09637486.2013.812620
  • Peer Reviewed
• [Presentation] An early pregnancy HbA1C predicts gestational diabetes independent of fasting glucose in Japanese pregnant women: TWC Study (2015)
  • Author(s): Yoko Yachi, Yasuhiro Tanaka, Ayumi Sugawara, Izumi Nishibata, Yoko Ibe, Fujihara Kazuya, Reiko Hirasawa, Satoru Kodama, Hirohito Sone
  • Organizer: The 25th Annual Scientific Meeting of the Japan Epidemiological Association
  • Place of Presentation: ウインクあいち
  • Year and Date: 2015-01-21 – 2015-01-23
• [Presentation] 妊娠中期における身体活動が糖代謝に与える影響の検討 (TWC Study) (2014)
  • Author(s): 谷内洋子、田中康弘、西端泉、広瀬歩美、藤原和哉、児玉暁、曽根博仁
  • Organizer: 第 30 回日本糖尿病・妊娠学会年次学術集会
  • Place of Presentation: 長崎ブリックホール
  • Year and Date: 2014-11-28 – 2014-11-29
• [Presentation] 日本人妊婦325名における、妊娠早期の炭水化物摂取量と50g糖負荷試験陽性リスクの関連 (2014)
  • Author(s): 田島諒子、飯田薫子、穴迫唯衣、田中康弘、曽根博仁、谷内洋子
  • Organizer: 第36回日本臨床栄養学会総会
  • Place of Presentation: ＪＰタワー ホール＆カンファレンス
  • Year and Date: 2014-10-04 – 2014-10-05
• [Presentation] 日本人女性の妊娠前後の体型および栄養摂取が母児の健康に及ぼす影響の検証-奨励賞受賞講演- (2014)
  • Author(s): 谷内洋子
  • Organizer: 栄養改善学会
  • Place of Presentation: パシフィコ横浜
  • Year and Date: 2014-08-20 – 2014-08-22
  • Invited
• [Presentation] 妊娠初期HbA1c値および空腹時血糖値と妊娠糖尿病発症との関連の検討（TWC Study) (2014)
  • Author(s): 谷内洋子、田中康弘、西端泉、広瀬歩美、児玉暁、齋藤和美、曽根博仁
  • Organizer: 第3回日本DOHaD研究会学術集会
  • Place of Presentation: 国立成育医療研究センター
  • Year and Date: 2014-07-25 – 2014-07-26
• [Presentation] 妊娠中期の身体活動量が糖代謝に及ぼす影響の検討(TWC Study) (2014)
  • Author(s): 谷内洋子、田中康弘、西端泉、由澤咲子、藤原和哉、児玉暁、鈴木亜希子、羽入修、曽根博仁
  • Organizer: 第57回日本糖尿病学会年次学術集会
  • Place of Presentation: 大阪国際会議場
  • Year and Date: 2014-05-22 – 2014-05-24
• [Presentation] 問診による糖尿病予測能のメタ解析 (2014)
  • Author(s): 由澤咲子、児玉暁、藤原和哉、堀川千嘉、菅原歩美、谷内洋子、山田貴穂、鈴木亜希子、羽入修、曽根博仁
  • Organizer: 第57回日本糖尿病学会年次学術集会
  • Place of Presentation: 大阪国際会議場
  • Year and Date: 2014-05-22 – 2014-05-24
• [Presentation] 糖尿病患者における、ヘリコバクター・ピロリ菌感染とその除菌成功率：メタアナリシスによる報告 (2014)
  • Author(s): 堀川千嘉、児玉暁、藤原和哉、谷内洋子、羽入修、島野仁、曽根博仁
  • Organizer: 第57回日本糖尿病学会年次学術集会
  • Place of Presentation: 大阪国際会議場
  • Year and Date: 2014-05-22 – 2014-05-24
• [Presentation] Second trimester postload glucose level as an important predictor of low birth weight infants (2014)
  • Author(s): 谷内洋子、田中康弘、曽根博仁
  • Organizer: 第66回日本産婦人科学会学術講演会
  • Place of Presentation: 東京国際フォーラム
  • Year and Date: 2014-04-18 – 2014-04-20
• [Presentation] 妊娠中の母体の血糖状態と低出生体重児出産との関連（TWC Study) (2014)
  • Author(s): 谷内洋子、田中康弘、西端泉、由澤咲子、藤原和哉、児玉暁、鈴木亜希子、羽入修、曽根博仁
  • Organizer: 第24回日本疫学会学術総会
  • Place of Presentation: 艮陵会館
• [Presentation] 妊娠初期HbA1c値と妊娠糖尿病発症との関連の検討(TWC Study). (2013)
  • Author(s): 谷内洋子, 田中康弘, 西端泉, 児玉暁, 鈴木亜希子,羽入修, 曽根博仁
  • Organizer: 第56回日本糖尿病学会年次学術集会
  • Place of Presentation: 熊本市民会館
• [Presentation] 母体の体重歴（二十歳時および妊娠時BMI）が母児の健康に及ぼす影響. (2013)
  • Author(s): 谷内洋子, 田中康弘, 西端泉, 菅原歩美, 児玉暁, 鈴木亜希子, 羽入修, 曽根博仁
  • Organizer: 第２回日本DOHaD研究会 学術集会
  • Place of Presentation: 厚生労働省戸山研究庁舎
• [Presentation] 妊娠初期空腹時血糖およびHbA1c値両者の同時測定は妊娠糖尿病発症を予測する指標として有用である（TWC Study）. (2013)
  • Author(s): 谷内洋子, 田中康弘, 西端泉, 由澤咲子, 藤原和哉, 児玉暁, 鈴木亜希子, 羽入修, 曽根博仁
  • Organizer: 第29回日本糖尿病・妊娠学会年次学術集会
  • Place of Presentation: 長良川国際会議場
• [Presentation] Relationship between Diabetic Neuropathy and Sleep Apnea Syndrome-A Meta-Analysis (2013)
  • Author(s): KAZUYA FUJIHARA, SATORU KODAMA, CHIKA HORIKAWA, AYUMI SUGAWARA, YORIKO HEIANZA, YOKO YACHI, KAZUMI SAITO, HITOSHI SHIMANO, OSAMU HANYU, HIROHITO SONE
  • Organizer: 73rd American Diabetes Association Scientific Sessions.
  • Place of Presentation: Chicago, US
• [Presentation] Relationship between Body Weight (BW) Gain from Early Adulthood and Incident Type 2 Diabetes (T2DM)-A Meta-Analysis (2013)
  • Author(s): SATORU KODAMA, CHIKA HORIKAWA, KAZUYA FUJIHARA, RYOKO TAJIMA, YORIKO HEIANZA, REIKO HIRASAWA, YOKO YACHI, KAORUKO T. IIDA, HITOSHI SHIMANO, OSAMU HANYU, HIROHITO SONE
  • Organizer: 73rd American Diabetes Association Scientific Sessions.
  • Place of Presentation: Chicago, US
• [Presentation] HbA1C in the First Trimester Predicts Gestational Diabetes Independent of Fasting Glucose in Japanese Pregnant Women: TWC Study (2013)
  • Author(s): Yoko Yachi, Yasuhiro Tanaka, Ayumi Sugawara, Izumi Nishibata, Chika Horikawa, Yoriko Heianza, Fujihara Kazuya, Satoru Kodama, Osamu Hanyu, Hirohito Sone
  • Organizer: 73rd American Diabetes Association Scientific Sessions.
  • Place of Presentation: Chicago, US
• [Presentation] Low Eradication Rate of Helicobacter Pylori (HP) in Patients with Diabetes: A Meta-Analysis (2013)
  • Author(s): CHIKA HORIKAWA, SATORU KODAMA, SAKIKO YOSHIZAWA, KAZUYA FUJIHARA, RYOKO TAJIMA, YOKO YACHI, AKIKO SUZUKI, OSAMU HANYU, HITOSHI SHIMANO, HIROHITO SONE
  • Organizer: 73rd American Diabetes Association Scientific Sessions.
  • Place of Presentation: Chicago, US
• [Presentation] Predictive ability of simple clinical information without blood tests for future incident diabetes: a meta-analysis. (2013)
  • Author(s): S. Yoshizawa, S. Kodama, K. Fujihara, C. Horikawa, A. Sugawara, Y. Heianza, Y. Yachi, S. Tanaka, S. Minakawa, T. Yamada, A. Suzuki, O. Hanyu, H. Sone
  • Organizer: 49th European Association for the Study of Diabetes.
  • Place of Presentation: Barcelona, Spain
• [Book] コンパクト 臨床栄養学 (2014)
  • Author(s): 長浜幸子、近藤雅雄、谷内洋子ほか
  • Publisher: 朝倉書店