| Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2014: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2013: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Outline of Final Research Achievements |
Lysophosphatidic acid (LPA) and sphingosine 1-phosphate (S1P) are bioactive lipid mediators that are crucial for the regulation of diverse biological processes. We assumed that abnormal production of LPA and S1P contribute to fat development in obesity, which leads to various diseases such as arteriosclerosis, coronary artery disease, diabetes and hypertension. By screening from commercially available polyphenols, we found that querctin, kempherol, robinetin, cathekin, propyl gallate, luteolin, resveratrol, curcumin, myricetin have inhibitory activities to LPA- and/or S1P-producing enzymes. In these polyphenols, quercetin, fisetin, luteolin, resveratrol and curcumin prevent cell differentiation and triacylglycerol synthesis, showing the foods contained these polyphenols are useful as anti-obesity food.
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