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Application to the clarification and treatment of molecular mechanism of iron metabolic disorders in hypertension

Research Project

Project/Area Number 25750044
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Eating habits
Research InstitutionKyushu University

Principal Investigator

Tajima Soichiro  九州大学, 大学病院, その他 (10579460)

Project Period (FY) 2013-04-01 – 2016-03-31
Project Status Completed (Fiscal Year 2015)
Budget Amount *help
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2014: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2013: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Keywords鉄代謝 / 高血圧症 / angiotensin II / ヘプシジン / 酸化ストレス / アンジオテンシンII / マクロファージ / iron regulatory protein / 鉄代謝関連蛋白質 / 鉄 / hepcidin
Outline of Final Research Achievements

We examined the effect of Ang II on duodenal iron transporters, hepatic hepcidin, and body iron storage. Serum hepcidin-25 concentration was lower in Ang II-infused mice compared to vehicle-treated mice, and this decrease was ameliorated by angiotensin II type 1 receptor antagonist administration. Protein expression of FPN and DMT1 was increased in the duodenum of Ang II-treated mice. Iron content was elevated in kidney and peritoneal macrophage from Ang II-treated mice. These results suggest that Ang II involves in body iron metabolism through the regulation of duodenal iron transporters via hepatic hepcidin and the alteration of body iron distribution. Inhibition of Ang II has a beneficial effect on correction of abnormal iron metabolism induced by Ang II.

Report

(4 results)
  • 2015 Annual Research Report   Final Research Report ( PDF )
  • 2014 Research-status Report
  • 2013 Research-status Report
  • Research Products

    (11 results)

All 2015 2014 2013

All Journal Article (6 results) (of which Peer Reviewed: 6 results,  Open Access: 4 results,  Acknowledgement Compliant: 1 results) Presentation (5 results) (of which Invited: 1 results)

  • [Journal Article] Pemetrexed-Induced Rash May Be Prevented by Supplementary Corticosteroids2015

    • Author(s)
      Takumi Sakurada, Soji Kakiuchi, Soichiro Tajima, Yuya Horinouchi, Ken Konaka, Naoto Okada, Hirotaka Nishisako, Toshimi Nakamura, Kazuhiko Teraoka, Kazuyoshi Kawazoe, Hiroaki Yanagawa, Yasuhiko Nishioka, Keisuke Ishizawa
    • Journal Title

      Biological and Pharmaceutical Bulletin

      Volume: 38 Issue: 11 Pages: 1752-1756

    • DOI

      10.1248/bpb.b15-00435

    • NAID

      130005106388

    • ISSN
      0918-6158, 1347-5215
    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Characteristics and risk factors of interstitial lung disease induced by chemotherapy for lung cancer2015

    • Author(s)
      Takumi Sakurada, Soji Kakiuchi, Soichiro Tajima, Yuya Horinouchi, Naoto Okada, Hirotaka Nishisako, Toshimi Nakamura, Kazuhiko Teraoka, Kazuyoshi Kawazoe, Hiroaki Yanagawa, Yasuhiko Nishioka, Kazuo Minakuchi, Keisuke Ishizawa
    • Journal Title

      The Annals Pharmacotherapy

      Volume: 49(4) Issue: 4 Pages: 398-404

    • DOI

      10.1177/1060028014566446

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Angiotensin II alters the expression of duodenal iron transporters, hepatic hepcidin, and body iron distribution in mice2015

    • Author(s)
      Soichiro Tajima, Yasumasa Ikeda, Hideaki Enomoto, Imao Mizuki, Yuya Horinouchi, Yuki Izawa-Ishizawa, Yoshitaka Kihira, Rihito Miyamoto, Keisuke Ishizawa, Koichiro Tsuchiya and Toshiaki Tamaki
    • Journal Title

      European Journal of Nutrition

      Volume: 印刷中 Issue: 5 Pages: 709-719

    • DOI

      10.1007/s00394-014-0749-1

    • NAID

      120006732013

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Iron chelation by deferoxamine prevents renal interstitial fibrosis in mice with unilateral ureteral obstruction.2014

    • Author(s)
      Ikeda Y, Ozono I, Tajima S, Imao M, Horinouchi Y, Izawa-Ishizawa Y, Kihira Y, Miyamoto L, Ishizawa K, Tsuchiya K, Tamaki T.
    • Journal Title

      PLoS One.

      Volume: 9 Issue: 2 Pages: e89355-e89355

    • DOI

      10.1371/journal.pone.0089355

    • Related Report
      2013 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Dietary iron restriction inhibits progression of diabetic nephropathy in db/db mice2013

    • Author(s)
      Yasumasa Ikeda, Hideaki Enomoto, Soichiro Tajima, Yuki Izawa-Ishizawa, Yoshitaka Kihira, Keisuke Ishizawa, Shuhei Tomita, Koichiro Tsuchiya, Toshiaki Tamaki
    • Journal Title

      Am J Physiol Renal Physiol.

      Volume: 304(7)

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] Bovine milk-derived lactoferrin exerts proangiogenic effects in an Src-Akt-eNOS-dependent manner in response to ischemia.2013

    • Author(s)
      Ikeda Yasumasa, et al
    • Journal Title

      J Cardiovasc Pharmacol

      Volume: 未定 Issue: 5 Pages: 423-429

    • DOI

      10.1097/fjc.0b013e318287d526

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Presentation] 呼吸器がん領域におけるイリノテカン塩酸塩投与患者の治療安全に対するUGT1A1遺伝子多型の影響2014

    • Author(s)
      田島 壮一郎
    • Organizer
      第31回日本薬学会九州支部大会
    • Place of Presentation
      福岡
    • Year and Date
      2014-12-06 – 2014-12-07
    • Related Report
      2014 Research-status Report
    • Invited
  • [Presentation] 肺癌薬物療法における薬剤性間質性肺炎の発症とそのリスク因子の解析2014

    • Author(s)
      櫻田 巧, 柿内 聡司, 田島 壮一郎, 寺岡 和彦, 中村 敏己, 川添 和義, 西岡 安彦, 楊河 宏章, 水口 和生
    • Organizer
      第55回日本肺癌学会学術集会
    • Place of Presentation
      京都
    • Year and Date
      2014-11-14 – 2014-11-16
    • Related Report
      2014 Research-status Report
  • [Presentation] アンジオテンシンIIは鉄吸収制御と生体内鉄分布変化に関与する2014

    • Author(s)
      池田 康将, 田島 壮一郎, 堀ノ内 裕也, 石澤 有紀, 木平 孝高, 宮本 理人, 石澤 啓介, 土屋 浩一郎, 玉置 俊晃
    • Organizer
      第125回日本薬理学会近畿部会
    • Place of Presentation
      岡山
    • Year and Date
      2014-06-20
    • Related Report
      2014 Research-status Report
  • [Presentation] Iron metabolic disorders in hypertension2014

    • Author(s)
      Soichiro Tajima, Nobuaki Egashira, Satohiro Masuda
    • Organizer
      第87回日本薬理学会年会
    • Place of Presentation
      仙台国際センター
    • Related Report
      2013 Research-status Report
  • [Presentation] アンジオテンシンIIは十二指腸鉄輸送体発現とマクロファージ鉄量を増加させる2014

    • Author(s)
      池田 康将, 田島 壮一郎, 石澤 有紀, 木平 孝高, 石澤 啓介, 土屋 浩一郎, 玉置 俊晃
    • Organizer
      第43回日本心脈管作動物質学会
    • Place of Presentation
      神戸国際会議場
    • Related Report
      2013 Research-status Report

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Published: 2014-07-25   Modified: 2019-07-29  

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