Application to the clarification and treatment of molecular mechanism of iron metabolic disorders in hypertension
| Project/Area Number |
25750044
|
|---|
| Research Category |
Grant-in-Aid for Young Scientists (B)
|
| Allocation Type | Multi-year Fund |
|---|
| Research Field |
Eating habits
|
|---|
| Research Institution | Kyushu University |
|---|
Principal Investigator |
|
|---|
| Project Period (FY) |
2013-04-01 – 2016-03-31
|
| Project Status |
Completed (Fiscal Year 2015)
|
| Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2014: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2013: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
|
|---|
| Keywords | 鉄代謝 / 高血圧症 / angiotensin II / ヘプシジン / 酸化ストレス / アンジオテンシンII / マクロファージ / iron regulatory protein / 鉄代謝関連蛋白質 / 鉄 / hepcidin |
|---|
| Outline of Final Research Achievements |
We examined the effect of Ang II on duodenal iron transporters, hepatic hepcidin, and body iron storage. Serum hepcidin-25 concentration was lower in Ang II-infused mice compared to vehicle-treated mice, and this decrease was ameliorated by angiotensin II type 1 receptor antagonist administration. Protein expression of FPN and DMT1 was increased in the duodenum of Ang II-treated mice. Iron content was elevated in kidney and peritoneal macrophage from Ang II-treated mice. These results suggest that Ang II involves in body iron metabolism through the regulation of duodenal iron transporters via hepatic hepcidin and the alteration of body iron distribution. Inhibition of Ang II has a beneficial effect on correction of abnormal iron metabolism induced by Ang II.
|
Report
(4 results)
Research Products
(11 results)
-
[Journal Article] Pemetrexed-Induced Rash May Be Prevented by Supplementary Corticosteroids2015
Author(s)
Takumi Sakurada, Soji Kakiuchi, Soichiro Tajima, Yuya Horinouchi, Ken Konaka, Naoto Okada, Hirotaka Nishisako, Toshimi Nakamura, Kazuhiko Teraoka, Kazuyoshi Kawazoe, Hiroaki Yanagawa, Yasuhiko Nishioka, Keisuke Ishizawa
-
Journal Title
Biol. Pharm. Bull.
Volume: 38
Issue: 11
Pages: 1752-1756
DOI
NAID
ISSN
0918-6158, 1347-5215
Related Report
Peer Reviewed / Open Access
-
-
[Journal Article] Angiotensin II alters the expression of duodenal iron transporters, hepatic hepcidin, and body iron distribution in mice.2015
Author(s)
Soichiro Tajima, Yasumasa Ikeda, Hideaki Enomoto, Imao Mizuki, Yuya Horinouchi, Yuki Izawa-Ishizawa, Yoshitaka Kihira, Rihito Miyamoto, Keisuke Ishizawa, Koichiro Tsuchiya and Toshiaki Tamaki
-
Journal Title
Eur J Nutr.
Volume: 印刷中
Pages: 709-719
DOI
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
-
[Journal Article] Iron chelation by deferoxamine prevents renal interstitial fibrosis in mice with unilateral ureteral obstruction2014
Author(s)
Ikeda Y, Ozono I, Tajima S, Imao M, Horinouchi Y, Izawa-Ishizawa Y, Kihira Y, Miyamoto L, Ishizawa K, Tsuchiya K, Tamaki T.
-
Journal Title
DOI
Related Report
Peer Reviewed / Open Access
-
-
-
-
-
-
-
