Identification of fatty acid composition in diet related to the liver carcinogenesis.

• Project/Area Number: 25750045
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Eating habits
• Research Institution: Ehime University
• Principal Investigator: MIYAKE Teruki 愛媛大学, 医学(系)研究科(研究院), 講師 (80573659)
• Project Period (FY): 2013-04-01 – 2015-03-31
• Project Status: Completed (Fiscal Year 2014)
• Budget Amount: ¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000); Fiscal Year 2014: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000); Fiscal Year 2013: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
• Keywords: トランス脂肪酸 / 肝臓癌 / 非アルコール性脂肪性肝疾患 / 非アルコール性脂肪肝炎 / 肝癌 / 脂肪酸 / 酸化ストレス / 発がん

Outline of Final Research Achievements

To examine the role of fatty acid composition in diet on carcinogenesis in the liver, we analyzed the lipid metabolism in obese mice induced by high fat diet contained high trans fatty acid, oleic acid, or palmitic acid. High trans fatty acid diet-fed mice exhibited increased amount of triglyceride in the liver compared with other groups. In addition, the expression levels of genes related to fatty acid synthesis and fat storage were increased in the liver from high trans fatty acid-fed mice. Moreover, the gene associated with ω-oxidation in the endoplasmic reticulum was also increased. These results indicate that composition of fatty acid in diet may alter the fatty acid metabolism and induce carcinoma in the liver.

Research Products

• [Journal Article] Significance of exercise in nonalcoholic fatty liver disease in men: a community-based large cross-sectional study. (2015)
  • Author(s): Miyake T, Kumagi T, Hirooka M, Furukawa S, Kawasaki K, Koizumi M, Todo Y, Yamamoto S, Nunoi H, Tokumoto Y, Ikeda Y, Abe M, Kitai K, Matsuura B, Hiasa Y.
  • Journal Title: J Gastroenterol Volume: 50 Issue: 2 Pages: 230-237
  • DOI: 10.1007/s00535-014-0959-6
  • Peer Reviewed / Open Access
• [Journal Article] Short sleep duration reduces the risk of nonalcoholic fatty liver disease onset in men: a community-based longitudinal cohort study. (2015)
  • Author(s): Miyake T, Kumagi T, Furukawa S, Hirooka M, Kawasaki K, Koizumi M, Todo Y, Yamamoto S, Tokumoto Y, Ikeda Y, Abe M, Kitai K, Matsuura B, Hiasa Y.
  • Journal Title: Journal of gastroenterology Volume: -
  • Peer Reviewed / Acknowledgement Compliant
• [Presentation] 男性の短時間睡眠はNAFLD発症に影響を及ぼす (2014)
  • Author(s): 三宅映己，熊木天児，藤堂裕彦，山本 晋，古川慎哉，新谷哲司，上田晃久，宮内省蔵，南 尚佳，酒井武則，宮岡弘明，谷口嘉康，恩地森一，日浅陽一，松浦文三
  • Organizer: 第52回日本糖尿病学会中国四国地方会総会
  • Place of Presentation: 広島
  • Year and Date: 2014-10-24 – 2014-10-25
• [Presentation] 性差が生活習慣と非アルコール性脂肪性肝疾患(NAFLD)の関係に及ぼす影響の検討 (2014)
  • Author(s): 三宅映己，熊木天児，藤堂裕彦，山本 晋，古川慎哉，徳本良雄，廣岡昌史，池田宜央，阿部雅則，松浦文三，日浅陽一
  • Organizer: 第101回日本消化器病学会四国支部例会
  • Place of Presentation: 愛媛
  • Year and Date: 2014-06-14 – 2014-06-15
• [Presentation] 非アルコール性脂肪性肝疾患(NAFLD)の病態における骨髄由来抑制細胞の関与 (2014)
  • Author(s): 阿部雅則，三宅映己，多田藤政，徳本良雄，川﨑敬太郎，越智裕紀，小泉洋平，廣岡昌史，松浦文三，日浅陽一
  • Organizer: 第50回日本肝臓学会総会
  • Place of Presentation: 東京
  • Year and Date: 2014-05-28 – 2014-05-30
• [Presentation] 検診受診者を対象とした生活習慣が非アルコール性脂肪性肝疾 (2014)
  • Author(s): 三宅映己，藤堂裕彦，山本 晋，古川慎哉，新谷哲司，上田晃久，宮内省蔵，南 尚佳，酒井武則，宮岡弘明，谷口嘉康，恩地森一，松浦文三，日浅陽一
  • Organizer: 第57回日本糖尿病学会年次学術集会
  • Place of Presentation: 大阪
  • Year and Date: 2014-05-22 – 2014-05-24
• [Presentation] Composition of serum fatty acids may be associated with the antiviral effects of interferon-based therapy in patients with hepatitis C virus infection. (2013)
  • Author(s): Miyake T, Abe M, Furukawa S, Hamada M, Ueda T, Yamamoto S, Niiya T, Kumagi T, Hiasa Y, Matsuura B, Onji M.
  • Organizer: 64th Annual Meeting of American Association for the Study of the Liver
  • Place of Presentation: Washington DC，USA