| Project/Area Number |
25750048
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Eating habits
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| Research Institution | University of Shizuoka |
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Principal Investigator |
UNNO Yuka 静岡県立大学, 薬学部, 助教 (30433212)
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| Project Period (FY) |
2013-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2014: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2013: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
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| Keywords | 肥満 / 炎症 / 脂肪細胞 / プロテアソーム / ヘテロクロマチン / 分化 / 表現型スクリーニング / 分子細胞生物学 / 阻害剤 / 細胞イメージング技術 / 創薬 / 評価システム |
|---|
| Outline of Final Research Achievements |
Being obese raises the risk of developing type 2 diabetes and other associated health problems. For treatment of obesity, a large reduction in caloric intake, along with increased physical activity, can produce a loss body weight over. But control caloric intake is not easy for us. In this study, I challenged to find new biomarker for ‘evaluation of anti-obesity activity’ using adipocyte. I found that several proteasome inhibitors have suppression effect of adipogenic differentiation in 3T3-L1 preadipocytes. Furthermore, one of proteasome inhibitors is selectivity towards immunoproteasome. These findings suggest that understanding roles of immunoproteasome in chronic local inflammation in adipose tissue is important for our study.
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