| Project/Area Number |
25750051
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Eating habits
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| Research Institution | University of Kochi |
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Principal Investigator |
TANAKA Mamoru 高知県立大学, その他部局等, 助教 (00612350)
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| Project Period (FY) |
2013-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2014: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2013: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Keywords | 抗アレルギー作用 / 牛乳由来ペプチド / 食物アレルギーモデルマウス / RBL-2H3 / アナフィラキシー評価 / 脱顆粒阻害 |
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| Outline of Final Research Achievements |
In this study, I evaluated anti-allergic effects of the HAQ peptide were investigated by using a mouse model and examined characteristic of peptides with anti-allergic effect using rat basophilic leukemia RBL-2H3 cells (RBL-2H3 ). As a result, it is suggested that continuous administration of HAQ peptide wasn’t suppressed antibodies production, but anti-allergic effects were suppressed by another mechanisms of action. Furthermore, the level of degranulation inhibitory activity depended on the number of histidine residues in peptide, and peptide sequence specificity is important for the manifestation of degranulastion inhibitory activity.
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