Galanin-like peptide (GALP) has an anti-obesity effect and acts through the energy metabolism by autonomic nervous system.

• Project/Area Number: 25750053
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Eating habits
• Research Institution: Showa University
• Principal Investigator: HIRAKO Satoshi 昭和大学, 医学部, ポスドク (90644261)
• Project Period (FY): 2013-04-01 – 2015-03-31
• Project Status: Completed (Fiscal Year 2014)
• Budget Amount: ¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000); Fiscal Year 2014: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000); Fiscal Year 2013: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
• Keywords: 脂質代謝 / エネルギー代謝 / 神経ペプチド / 抗肥満 / 交感神経 / 末梢組織 / ガラニン用ペプチド / 脂肪組織 / 肝臓

Outline of Final Research Achievements

Galanin-like peptide (GALP), a 60-amino acid neuropeptide that was originally isolated from porcine hypothalamic extracts and is well known as a neuropeptide regulating feeding behavior and energy metabolism. In this study, I examined anti-obesity effect of GALP by focusing on lipid metabolism. In chronic infusion study, the body weight gain was decreased by GALP treatment as compared with the control group. The amount of lipid droplets was lower in the GALP group and hepatic triglyceride levels was decreased in the GALP groups compared with the vehicle group. Hepatic fatty acid oxidation-related gene mRNA levels were increased in the GALP group.The present study indicates that stimulates the hepatic lipid metabolism and anti-obese effect of GALP is evident with both central and intranasal administration.

Research Products

• [Journal Article] Galanin-like peptide prevent obesity by control of food intake and energy metabolism. (2014)
  • Author(s): Hirako S, Takenoya F, Kageyama H, Wada N, Okabe M, Shioda S.
  • Journal Title: Pharm Anal Acta Volume: 5 Issue: 05 Pages: 1-5
  • DOI: 10.4172/2153-2435.1000297
  • Peer Reviewed / Open Access
• [Journal Article] Leptin and its receptors. (2014)
  • Author(s): Wada N, Hirako S, Takenoya F, Kageyama H, Okabe M, Shioda S.
  • Journal Title: J Chem Neuroanat. Volume: 61-62 Pages: 191-199
  • DOI: 10.1016/j.jchemneu.2014.09.002
  • Peer Reviewed
• [Journal Article] Vagal hyperactivity due to ventromedial hypothalamic lesions increases adiponectin production and release. (2014)
  • Author(s): Suzuki Y, Shimizu H, Ishizuka N, Kubota N, Kubota T, Senoo A, Kageyama H, Osaka T, Hirako S, Kim HJ, Matsumoto A, Shioda S, Mori M, Kadowaki T, Inoue S.
  • Journal Title: Diabetes. Volume: 63(5) Issue: 5 Pages: 1637-1648
  • DOI: 10.2337/db13-0636
  • Peer Reviewed
• [Journal Article] Upregulated Expression of AQP 7 in the Skeletal Muscles of Obese ob/ob Mice (2014)
  • Author(s): Wakayama Y, Hirako S, Ogawa T, Jimi T, Shioda S.
  • Journal Title: ACTA HISTOCHEMICA ET CYTOCHEMICA Volume: 47 Issue: 1 Pages: 27-33
  • DOI: 10.1267/ahc.13032
  • NAID: 130003390843
  • ISSN: 0044-5991, 1347-5800
  • Peer Reviewed
• [Journal Article] Interactive effect of galanin-like peptide (GALP) and spontaneous exercise on energy metabolism. (2013)
  • Author(s): Ito K, Kageyama H, Hirako S, Wang L, Takenoya F, Ogawa T, Shioda S.
  • Journal Title: Peptides. Volume: 49 Pages: 109-116
  • Peer Reviewed
• [Journal Article] Development of a new method of intranasal injection of GALP regarding clinical application to obese people. (2013)
  • Author(s): Takenoya F, Hirako S, Kageyama H, Nonaka N, Shioda S.
  • Journal Title: Drug Delivery System Volume: 28 Pages: 300-309
  • NAID: 130003384380
  • Peer Reviewed
• [Presentation] Effect of GALP on lipid metabolism in the liver. (2015)
  • Author(s): Hirako S, Takaenoya F, Wada N, Kageyama H, Shioda S
  • Organizer: 第120回日本解剖学会総会・全国学術集会
  • Place of Presentation: 神戸
  • Year and Date: 2015-03-21 – 2015-03-23
• [Presentation] 抗肥満ペプチドGALPによるエネルギー代謝調節機構. (2015)
  • Author(s): 平子哲史・竹ノ谷文子・影山晴秋・和田亘弘・塩田清二
  • Organizer: 第29回日本糖尿病・肥満動物学会
  • Place of Presentation: 京都
  • Year and Date: 2015-02-13 – 2015-02-14
• [Presentation] Galanin-like peptide (GALP) have the anti-obesity effect and control of energy metabolism via the sympathetic nervous system. (2014)
  • Author(s): Hirako S, Kageyama H, Takaenoya F, Wada N, Kimura A, Okabe M, Shioda S
  • Organizer: 44st Annual meeting Society for Neuroscience
  • Place of Presentation: Washington, DC
  • Year and Date: 2014-11-15 – 2014-11-19
• [Presentation] Effect of GALP on lipid metabolism and body weight regulation. (2014)
  • Author(s): Hirako S, Kageyama H, Takaenoya F, Wada N, Kimura A, Okabe M, Shioda S
  • Organizer: Obesity week 2014
  • Place of Presentation: Boston, MA
  • Year and Date: 2014-11-02 – 2014-11-07
• [Presentation] 摂食調節ペプチドGALP点鼻投与による脂質代謝改善メカニズムの解明. (2014)
  • Author(s): 平子哲史・竹ノ谷文子・影山晴秋・和田亘弘・木村 愛・岡部まい・塩田清二
  • Organizer: 第35回日本肥満学会
  • Place of Presentation: 宮崎
  • Year and Date: 2014-10-24 – 2014-10-25
• [Presentation] Energy metabolism regulation by intracerebroventricular and intranasal administration of GALP. (2014)
  • Author(s): Hirako S, Kageyama H, Takaenoya F, Wada N, Kimura A, Okabe M, Shioda S
  • Organizer: 20th International Symposium on Regulatory Peptides
  • Place of Presentation: kyoto
  • Year and Date: 2014-09-07 – 2014-09-10
• [Presentation] ガラニン様ペプチド(GALP)による肥満症・脂質異常症の予防効果及びその機序. (2014)
  • Author(s): 平子哲史・影山晴秋・竹ノ谷文子・太田英司・和田亘弘・塩田清二
  • Organizer: 第46回日本動脈硬化学会総会・学術集会
  • Place of Presentation: 東京
  • Year and Date: 2014-07-10 – 2014-07-11
• [Presentation] ガラニン様ペプチド(GALP)によるメタボリックシンドロームの予防・治療法の研究. (2014)
  • Author(s): 平子哲史・影山晴秋・竹ノ谷文子・太田英司・和田亘弘・塩田清二
  • Organizer: 第68会日本栄養・食糧学会大会
  • Place of Presentation: 北海道
  • Year and Date: 2014-05-30 – 2014-06-01
• [Presentation] ガラニン様ペプチドの末梢組織におけるエネルギー代謝制御機構の解明. (2014)
  • Author(s): 平子哲史・影山晴秋・竹ノ谷文子・太田英司・和田亘弘・塩田清二
  • Organizer: 第11回GPCR研究会
  • Place of Presentation: 東京
  • Year and Date: 2014-05-09 – 2014-05-10
• [Presentation] Galanin-like peptide (GALP) have anti-obesity effect via the activation of hepatic lipid metabolism. (2014)
  • Author(s): Hirako S, Kageyama H, Takenoya F, Ota E, Wada N, Shioda S
  • Organizer: The 2014 obesity summit
  • Place of Presentation: London, UK
  • Year and Date: 2014-04-01 – 2014-04-03
  • Invited
• [Presentation] ガラニン様ペプチド（GALP）投与による抗肥満作用とその機序 (2014)
  • Author(s): 平子哲史・影山晴秋・竹ノ谷文子・太田英司・和田亘弘・塩田清二
  • Organizer: 第28回日本糖尿病・肥満動物学会
  • Place of Presentation: 宮崎市民プラザ(宮崎)
• [Presentation] ガラニン様ペプチド(GALP)による肥満症軽減作用及びその作用機序の解明 (2014)
  • Author(s): 平子哲史・影山晴秋・竹ノ谷文子・太田英司・和田亘弘・塩田清二
  • Organizer: 第119回日本解剖学会総会・全国学術集会
  • Place of Presentation: 自治医科大学(栃木)
• [Presentation] ガラニン様ペプチド（GALP）による肝臓脂質代謝改善作用 (2013)
  • Author(s): 平子哲史・影山晴秋・小川哲郎・竹ノ谷文子・太田英司・和田亘弘・塩田清二
  • Organizer: 第67会日本栄養・食糧学会大会
  • Place of Presentation: 名古屋大学(名古屋)
• [Presentation] ガラニン様ペプチド（GALP）による脂質代謝改善メカニズムの解明 (2013)
  • Author(s): 平子哲史・影山晴秋・竹ノ谷文子・太田英司・和田亘弘・塩田清二
  • Organizer: 第45回日本動脈硬化学会総会・学術集会
  • Place of Presentation: 京王プラザホテル(東京)
• [Presentation] ガラニン様ペプチド（GALP）による交感神経を介した肝臓脂質代謝調節作用 (2013)
  • Author(s): 平子哲史・影山晴秋・竹ノ谷文子・太田英司・和田亘弘・塩田清二
  • Organizer: 第18回アディポサイエンスシンポジウム
  • Place of Presentation: 千里ライフサイエンスセンター(大阪)
• [Presentation] ガラニン様ペプチド（GALP）投与による肥満症軽減メカニズムの解明 (2013)
  • Author(s): 平子哲史・影山晴秋・竹ノ谷文子・太田英司・和田亘弘・塩田清二
  • Organizer: 第34回日本肥満学会
  • Place of Presentation: 東京国際フォーラム(東京)
• [Presentation] Galanin-like peptide (GALP):a key player in the regulation of feeding and energy metabolism (2013)
  • Author(s): Hirako S, Kageyama H, Takenoya F, Ota E, Wada N, Shioda S
  • Organizer: Galanin SFN pre-meeting 2013
  • Place of Presentation: San Diedo, USA
• [Presentation] Galanin-like peptide (GALP) ameliorates hepatic lipid metabolism via the sympathetic nervous system. (2013)
  • Author(s): Hirako S, Kageyama H, Takenoya F, Ota E, Wada N, Shioda S
  • Organizer: 43st Annual meeting Society for Neuroscience
  • Place of Presentation: San Diedo, USA