| Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2015: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2014: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2013: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Outline of Final Research Achievements |
This study investigated the effects of iron deficiency diet on inflammation and senescence in vivo and in vitro. (1)We investigated the effects of dietary iron deficiency on the redox system in young or old mice. Dietary iron deficiency increased accumulation of carbonylated proteins and expression levels of an antioxidant enzymes and an autophagic marker compared to control diet. (2)Iron-specific chelator induce protein aggregation by increasing gene expression of p47phox. In addition, DFO treatment upregulated the expression of the autophagic genes during autophagy and anti-oxidant enzymes. Furthermore, DFO treatment also increased senescence-related molecules. These results suggested that anti-oxidant systems and autophagy in iron deficient condition protects from oxidative stress.
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