| Project/Area Number |
25750060
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Eating habits
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| Research Institution | Aichi Gakusen University |
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Principal Investigator |
Uchida Tomono 愛知学泉大学, 家政学部, 准教授 (50440821)
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| Research Collaborator |
IKEDA SAIKO 名古屋学芸大学, 管理栄養学部, 教授
SUZUKI NORIE 名古屋学芸大学, 管理栄養学部, 助手
エーザイフード・ケミカル株式会社
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| Project Period (FY) |
2013-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2015: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2014: ¥520,000 (Direct Cost: ¥400,000、Indirect Cost: ¥120,000)
Fiscal Year 2013: ¥3,250,000 (Direct Cost: ¥2,500,000、Indirect Cost: ¥750,000)
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| Keywords | ビタミンE / γ-トコフェロール / ゴマリグナン / セサミン / γ－トコフェロール / ビタミンE濃度 / 腸管吸収量 |
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| Outline of Final Research Achievements |
Inhibition of lipoprotein lipase in rats, the effect of sesamin to increase vitamin E concentration was investigated.Serum and small intestinal γT concentrations increased due to ingestion of γT (one type of vitamin E) and sesamin, but the metabolite of γT (γ-CEHC) decreased.Therefore, sesamin inhibits γT metabolism in the small intestine,and Sesamin was supposed to promote γT absorption.Furthermore, when healthy people ingest sesame and γT, urinary metabolites(γ-CEHC) excretion decreases. The plasma γT concentration also tended to increase.Therefore, we concluded that inhibition of vitamin E metabolism by sesamin ingestion is also seen in humans.We expected antioxidant lipid suppression effect due to elevation of vitamin E concentration in the body,but this time it was not confirmed.
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