| Budget Amount *help |
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2015: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2014: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2013: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
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| Outline of Final Research Achievements |
To examine the the association between vitamin D status and sarcopenia, we have performed two cross-sectional studies; one for healthy 43 institutionalized elderly subjects and one for 40 middle-aged healthy adults to study the role of vitamin D on muscle strength and physical activity.
In multiple regression analysis, serum 25-hydroxyvitamin D (25OHD) level was a significant positive factor for physical performance in elderly subjects and for lower limb muscle strength in middle-aged adults. However, serum 25OHD level did not significantly contribute to the skeletal muscle mass index (SMI) in either study.
Muscle strength is composed of muscle mass and the quality of muscle, such as fat filtration of muscle. Since our study suggested that serum 25OHD level were more strongly correlated with the quality of muscle compared with muscle mass, further studies evaluating fat filtration of muscle by magnetic resonance imaging (MRI) are required to perform.
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