| Project/Area Number |
25750068
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Eating habits
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| Research Institution | National Center for Geriatrics and Gerontology |
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Principal Investigator |
OKUNO Alato 国立研究開発法人国立長寿医療研究センター, ラジオアイソトープ管理室, 研究員 (50623980)
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2015: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2014: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2013: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Keywords | トリプトファン / キヌレン酸 / キノリン酸 / 栄養 / アルツハイマー病 / アミロイドβ |
|---|
| Outline of Final Research Achievements |
Tryptophan (Trp) metabolism within the mammalian brain mainly occurs through the kynurenine pathway, where both the endogenous neuro-protective mediator, kynurenic acid (KYNA) and the endogenous excitatory neurotoxin, quinolinic acid (QA) are generated. Increase in KYNA/QA ratio in the brain is thought to be neuro-protective against some neurodegenerative diseases. To examine the possible effect of Trp intake on the change of the KYNA/QA ration in the brain, 0, 0.5, 1.0, 2.0, 5.0% Trp supplementation to 20% casein diet were fed to 20 weeks old C57BL6/J male mice for 28 weeks. As a result, the 1-5% Trp supplementation caused a decrease in the KYNA/QA ratio in brain. Furthermore, a systemic inflammation (a 5-fold increase in plasma level of IFN-γ). These results suggest that a simple Trp supplementation to AD patients worsens rather than suppresses neural degeneration by decrease in the KYNA/QA ratio and by increase in systemic inflammation.
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