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Development of a new continuum model of blood based on cellular scale RBC behaviors

Research Project

Project/Area Number 25750155
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Biomedical engineering/Biomaterial science and engineering
Research InstitutionTohoku University

Principal Investigator

Omori Toshihiro  東北大学, 工学(系)研究科(研究院), 助教 (10633456)

Project Period (FY) 2013-04-01 – 2016-03-31
Project Status Completed (Fiscal Year 2015)
Budget Amount *help
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2015: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2014: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2013: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Keywords計算生体力学 / 赤血球 / 血流 / バイオエンジニアリング / 細胞懸濁液 / 血液連続体モデル / サスペンション
Outline of Final Research Achievements

Blood is a dense suspension of red blood cells (RBCs), and RBC behaviors strongly affect mass transport of blood flow. Thus, we need to consider micro scale RBC motions when we discuss the mass transport of blood flow. However, in many cases, blood was assumed as a homogeneous liquid in former studies. Then, we need to develop a completely new continuum model of blood, which is based on cellular scale RBC behaviors. In this study, we developed a computational model of red blood cells using a finite element-boundary element coupling method, and by using the developed RBC model, we calculated a particle stress tensor and shear-induced diffusion of red blood cells in order to develop a new continuum model of blood.

Report

(4 results)
  • 2015 Annual Research Report   Final Research Report ( PDF )
  • 2014 Research-status Report
  • 2013 Research-status Report
  • Research Products

    (14 results)

All 2015 2014 2013

All Journal Article (4 results) (of which Peer Reviewed: 4 results,  Open Access: 3 results) Presentation (10 results) (of which Int'l Joint Research: 3 results,  Invited: 6 results)

  • [Journal Article] Hemodynamics in the microcirculation and in microfluidics2015

    • Author(s)
      Omori, T., Imai, Y., Kikuchi, K., Ishikawa, T., Yamaguchi, T.
    • Journal Title

      Annals of Biomedical Engineering

      Volume: 43 Issue: 1 Pages: 238-257

    • DOI

      10.1007/s10439-014-1180-8

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] A full GPU implementation of a numerical method for simulating capsule suspensions2014

    • Author(s)
      Daiki Matsunaga, Yohsuke Imai, Toshihiro Omori, Takami Yamaguchi, Takuji Ishikawa
    • Journal Title

      Journal of Biomechanical Science and Engineering

      Volume: 9 Issue: 3 Pages: 14-00039-14-00039

    • DOI

      10.1299/jbse.14-00039

    • NAID

      130004678607

    • ISSN
      1880-9863
    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Numerical analysis of a red blood cell flowing through a thin micropore2014

    • Author(s)
      Toshihiro Omori, Haruki Hosaka, Yhosuke Imai, Takami Yamaguchi, and Takuji Ishikawa
    • Journal Title

      Physical Review E

      Volume: 89 Pages: 13008-13008

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] Hydrodynamic interaction between two red blood cells in simple shear flow: its impact on the rheology of a semi-dilute suspension2014

    • Author(s)
      Omori, T., Ishikawa, T., Imai, Y., Yamaguchi, T.
    • Journal Title

      Computational Mechanics

      Volume: 54 Issue: 4 Pages: 933-941

    • DOI

      10.1007/s00466-014-0997-1

    • Related Report
      2013 Research-status Report
    • Peer Reviewed / Open Access
  • [Presentation] A boundary element method for cellular scale physiological flow problems2015

    • Author(s)
      Toshihiro Omori, Yohsuke Imai, Takami Yamaguchi and Takuji Ishikawa
    • Organizer
      International Workshops on Advances in Computational Mechanics
    • Place of Presentation
      KFC Hall & Rooms, Tokyo, Japan
    • Year and Date
      2015-10-12
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Cellular scale physiological flow: active swimming sperm cells and passive flowing red blood cells2015

    • Author(s)
      Toshihiro Omori, Takuji Ishikawa, Yohsuke Imai, and Takami Yamaguchi
    • Organizer
      13th US national congress on computational mechanics
    • Place of Presentation
      Sandiego, California, USA
    • Year and Date
      2015-07-27
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] A computational study of red blood cells in Stokes flow: from single cellular mecanics to suspension rheolgy2015

    • Author(s)
      Toshihiro Omori, Yohsuke Imai, Takami Yamaguchi and Takuji Ishikawa
    • Organizer
      Summer Biomechanics, bioengineering and biotransport conference 2015
    • Place of Presentation
      Snowbird, Utah, USA
    • Year and Date
      2015-06-17
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Rheology of A Red Blood Cell Suspension Computing with A Boundary Element-Finite Element Coupled Method2015

    • Author(s)
      T.Omori, Y.Imai, T.Ishikawa
    • Organizer
      18th International Conference on Finite Elements in Flow Problems
    • Place of Presentation
      台北,台湾
    • Year and Date
      2015-03-16
    • Related Report
      2014 Research-status Report
    • Invited
  • [Presentation] 境界要素法・有限要素法によるカプセル流動の数値計算2014

    • Author(s)
      大森俊宏
    • Organizer
      可視化情報シンポジウム2014
    • Place of Presentation
      東京,工学院大学新宿キャンパス
    • Year and Date
      2014-07-21
    • Related Report
      2014 Research-status Report
    • Invited
  • [Presentation] Rheology of a red blood cell suspension in a simple shear flow2014

    • Author(s)
      T.Omori, Y.Imai, D.Matsunaga, T.Yamaguchi, T.Ishikawa,
    • Organizer
      7th World Congress of Biomechanics
    • Place of Presentation
      Boston, USA
    • Year and Date
      2014-07-07
    • Related Report
      2014 Research-status Report
    • Invited
  • [Presentation] Rheology of a Red Blood Cell Suspension from Dilute to Semi-dilute Regime2014

    • Author(s)
      T.Omori, Y.Imai, TYamaguchi, T.Ishikawa
    • Organizer
      International Symposium on Integrated Nanobiomechanics
    • Place of Presentation
      Boston, USA
    • Year and Date
      2014-07-05
    • Related Report
      2014 Research-status Report
  • [Presentation] 微小流路内を流れる赤血球の変形挙動解析2014

    • Author(s)
      大森俊宏,石川拓司,今井陽介,山口隆美
    • Organizer
      第26回バイオエンジニアリング講演会
    • Place of Presentation
      東北大学片平キャンパス
    • Related Report
      2013 Research-status Report
  • [Presentation] Integrated Biomechanics for Physiological Problems2013

    • Author(s)
      Takami Yamaguchi, Yohsuke Imai, Toshihiro Omori, Hironori Ueno, Keiko Numayama-Tsuruta, Takuji Ishikawa
    • Organizer
      The 7th Asian Pacific Conference on Biomechanics
    • Place of Presentation
      Seoul, Korea
    • Related Report
      2013 Research-status Report
    • Invited
  • [Presentation] Effect of Aeration on the Biconvection Pattern in a Microalgae Suspension2013

    • Author(s)
      Yuki Nonaka, Hironori Ueno, Keiko Numayama, Toshihiro Omori, Yohsuke Imai, Takami Yamaguchi, Takuji Ishikawa
    • Organizer
      The 7th Asian Pacific Conference on Biomechanics
    • Place of Presentation
      Seoul, Korea
    • Related Report
      2013 Research-status Report

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Published: 2014-07-25   Modified: 2019-07-29  

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