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Development of cell-vibration microdevice wiht piezoelectric thin film

Research Project

Project/Area Number 25750158
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Biomedical engineering/Biomaterial science and engineering
Research InstitutionToyohashi University of Technology

Principal Investigator

KAWASHIMA Takahiro  豊橋技術科学大学, 工学(系)研究科(研究院), 准教授 (50378270)

Project Period (FY) 2013-04-01 – 2015-03-31
Project Status Completed (Fiscal Year 2014)
Budget Amount *help
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2014: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2013: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
Keywords細胞機能制御 / 機械的振動刺激 / 圧電アクチュエータ / BioMEMS
Outline of Final Research Achievements

In this study, we have been developing a cell-vibration microdevice with piezoelectric thin film for screening and optimization of the influencing factors of mechanical vibratory stimuli to cells. The microdevice was fabricated by the proposed fabrication process. Moreover, a cell arrangement method using dielectrophoresis was adopted to trap cells on the microdevice. The study revealed that the method was effective to trap cells. Finally, cell culture experiments were executed in order to evaluate cell adhesion on substrates. As a result, it was found that the surface material of the microdevice was important to cell behavior.

Report

(3 results)
  • 2014 Annual Research Report   Final Research Report ( PDF )
  • 2013 Research-status Report
  • Research Products

    (6 results)

All 2015 2014 2013 Other

All Presentation (5 results) Remarks (1 results)

  • [Presentation] オンチップ細胞機能制御のための圧電駆動型マイクロ細胞培養デバイスの開発(第 4 報):機械的ナノ振動刺激による細胞応答の基礎的検討2015

    • Author(s)
      小林功治,永井萌土,川島貴弘,柴田隆行
    • Organizer
      2015年度精密工学会春季大会学術講演会
    • Place of Presentation
      東洋大学(東京)
    • Year and Date
      2015-03-17 – 2015-03-19
    • Related Report
      2014 Annual Research Report
  • [Presentation] オンチップ細胞機能制御のための圧電駆動型マイクロ細胞培養デバイスの開発(第3報) ―誘電泳動を利用した高効率細胞配列技術の検討―2014

    • Author(s)
      梅垣彦希,石原祥貴,永井萌土,川島貴弘,柴田隆行
    • Organizer
      2014年度精密工学会春季大会学術講演会
    • Place of Presentation
      東京
    • Related Report
      2013 Research-status Report
  • [Presentation] Development of Cell Culture Microdevice for Regulation of Cell Functions Based on Nanomechanical Stimulation2013

    • Author(s)
      G. Umegaki, Y. Ishihara, M. Nagai, T. Kawashima, T. Shibata
    • Organizer
      24th 2013 International Symposium on Micro-NanoMechatronics and Human Science (MHS 2013)
    • Place of Presentation
      Nagoya, Japan
    • Related Report
      2013 Research-status Report
  • [Presentation] Fabrication and Characterization of Cell Culture Microdevice for Nanomechanical Stimulation of Living Cells2013

    • Author(s)
      G. Umegaki, Y. Ishihara, M. Nagai, T. Kawashima, T. Shibata
    • Organizer
      The Irago (Interdisciplinary Research and Global Outlook) Conference 2013
    • Place of Presentation
      Aichi, Japan
    • Related Report
      2013 Research-status Report
  • [Presentation] オンチップ細胞機能制御のための圧電駆動型マイクロ細胞培養デバイスの開発(第2報) ―誘電泳動による細胞操作の基礎的検討―2013

    • Author(s)
      梅垣彦希,石原祥貴,永井萌土,川島貴弘,柴田隆行,増澤 徹,木村 剛,岸田晶夫
    • Organizer
      2013年度精密工学会秋季大会学術講演会
    • Place of Presentation
      大阪
    • Related Report
      2013 Research-status Report
  • [Remarks]

    • URL

      http://mems.me.tut.ac.jp/research.html

    • Related Report
      2014 Annual Research Report

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Published: 2014-07-25   Modified: 2019-07-29  

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