| Project/Area Number |
25750171
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Biomedical engineering/Biomaterial science and engineering
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| Research Institution | Chiba University |
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Principal Investigator |
YAMADA Masumi 千葉大学, 工学(系)研究科(研究院), 准教授 (30546784)
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| Project Period (FY) |
2013-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2014: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2013: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Keywords | ハイドロゲル / 生体組織工学 / 血管 / 肝臓 / マイクロ流体デバイス / マイクロ・ナノ科学 / 生体医工学 / バイオマテリアル / 組織工学 / 肝細胞 |
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| Outline of Final Research Achievements |
We have developed new strategies for reconstructing three-dimensional tissues in vitro, which are composed of densely packed cells with precise alignments. In order to achieve this, we proposed a process to pile up non-spherical unit cellular aggregates composed of multiple types of cells. First, anisotropic hydrogel microfibers or non-cell-adhesive microchambers were used to prepare linear organoids and anisotropic toroidal aggregates. Then, by organizing these unit structures within perfusion chambers or channels, we prepared high-density cellular tissues incorporating vascular networks and thick blood vessel models. In addition, we evaluated the effects of perfusion culture conditions on the functions of liver and blood tissues.
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