Fabrication of self-assembled nanoparticles using homo/hetero-stereocomplex formation of poly(lactide)
| Project/Area Number |
25750174
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Biomedical engineering/Biomaterial science and engineering
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| Research Institution | Osaka University |
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Principal Investigator |
AKAGI Takami 大阪大学, 臨床医工学融合研究教育センター, 特任研究員(常勤) (00527236)
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| Project Period (FY) |
2013-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2014: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Fiscal Year 2013: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | ナノ粒子 / ポリ乳酸 / ステレオコンプレックス / ドラッグデリバリーシステム / ワクチン / ドラックデリバリーシステム |
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| Outline of Final Research Achievements |
Self-assembled nanoparticles (NPs) composed of poly(γ-glutamic acid) (γ-PGA) as a hydrophilic backbone and enantiomeric poly(lactide) (PLA) as a hydrophobic side chain were prepared using stereocomplex (SC) formation of PLA. The γ-PGA-PLA SC NPs exhibit a lower critical aggregation concentration (CAC) as well as stronger kinetic stability compared with the corresponding isomer NPs. Moreover, mouse immunization with ovalbumin (OVA)-encapsulated SC NPs predominantly induced OVA-specific cellular immunity. The findings suggest that the γ-PGA-PLA SC NPs are suitable for protein-based vaccines that are used to induce cellular immunity, such as for infectious diseases, cancer, allergies and autoimmune diseases.
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Report
(3 results)
Research Products
(13 results)
