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Fabrication of self-assembled nanoparticles using homo/hetero-stereocomplex formation of poly(lactide)

Research Project

Project/Area Number 25750174
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Biomedical engineering/Biomaterial science and engineering
Research InstitutionOsaka University

Principal Investigator

AKAGI Takami  大阪大学, 臨床医工学融合研究教育センター, 特任研究員(常勤) (00527236)

Project Period (FY) 2013-04-01 – 2015-03-31
Project Status Completed (Fiscal Year 2014)
Budget Amount *help
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2014: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Fiscal Year 2013: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Keywordsナノ粒子 / ポリ乳酸 / ステレオコンプレックス / ドラッグデリバリーシステム / ワクチン / ドラックデリバリーシステム
Outline of Final Research Achievements

Self-assembled nanoparticles (NPs) composed of poly(γ-glutamic acid) (γ-PGA) as a hydrophilic backbone and enantiomeric poly(lactide) (PLA) as a hydrophobic side chain were prepared using stereocomplex (SC) formation of PLA. The γ-PGA-PLA SC NPs exhibit a lower critical aggregation concentration (CAC) as well as stronger kinetic stability compared with the corresponding isomer NPs. Moreover, mouse immunization with ovalbumin (OVA)-encapsulated SC NPs predominantly induced OVA-specific cellular immunity. The findings suggest that the γ-PGA-PLA SC NPs are suitable for protein-based vaccines that are used to induce cellular immunity, such as for infectious diseases, cancer, allergies and autoimmune diseases.

Report

(3 results)
  • 2014 Annual Research Report   Final Research Report ( PDF )
  • 2013 Research-status Report
  • Research Products

    (13 results)

All 2015 2014 2013 Other

All Journal Article (3 results) (of which Peer Reviewed: 2 results) Presentation (8 results) Book (2 results)

  • [Journal Article] ナノ粒子アジュバントを用いたワクチン開発2014

    • Author(s)
      赤木隆美, 明石 満
    • Journal Title

      最新医学

      Volume: 69 Pages: 81-89

    • Related Report
      2014 Annual Research Report
  • [Journal Article] Biodegradable nanoparticles composed of enantiomeric poly(γ-glutamicacid)-graft-poly(lactide) copolymers as vaccine carriers for dominant induction of cellular immunity2014

    • Author(s)
      Takami Akagi, Ye Zhu, Fumiaki Shima, Mitsuru Akashi
    • Journal Title

      Biomater. Sci.

      Volume: 2 Issue: 4 Pages: 530-537

    • DOI

      10.1039/c3bm60279f

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] Self-assembling stereocomplex nanoparticles by enantiomeric poly(γ-glutamic acid)-poly(lactide) graft copolymers as a protein delivery carrier2014

    • Author(s)
      Ye Zhu, Takami Akagi, Mitsuru Akashi
    • Journal Title

      Maromol. Biosci.

      Volume: 14 Issue: 4 Pages: 576-587

    • DOI

      10.1002/mabi.201300434

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Presentation] Manipulating the Antigen-Specific Immune Responses by Particulate Adjuvants Consisting of Amphiphilic Poly(Amino Acid)2014

    • Author(s)
      Takami Akagi, Fumiaki Shima, Tomofumi Uto, Mitsuru Akashi
    • Organizer
      The 10th SPSJ International Polymer Conference (IPC 2014)
    • Place of Presentation
      つくば国際会議場(茨城県つくば市)
    • Year and Date
      2014-12-02 – 2014-12-05
    • Related Report
      2014 Annual Research Report
  • [Presentation] Design and Creation of Nanoparticles by Assembly of Amphiphilic Poly(amino acid) and Their DDS Applications2014

    • Author(s)
      Mitsuru Akashi, Fumiaki Shima, Tomofumi Uto, Paninee Chetprayoon, Michiya Matsusaki, Takami Akagi, Masanori Baba
    • Organizer
      11th France-Japan DDS Symposium
    • Place of Presentation
      Awaji Yumebutai International Conference Center (Hyogo, Japan)
    • Year and Date
      2014-10-05 – 2014-10-08
    • Related Report
      2014 Annual Research Report
  • [Presentation] ステレオコンプレックス形成を使用したポリ(γ-グルタミン酸)-ポリ乳酸グラフト共重合体からなるナノ粒子の調製とワクチンキャリアとしての機能評価2014

    • Author(s)
      赤木隆美, 朱 葉, 明石 満
    • Organizer
      第63回高分子年次大会
    • Place of Presentation
      名古屋国際会議場(愛知県名古屋市)
    • Year and Date
      2014-05-28 – 2014-05-30
    • Related Report
      2014 Annual Research Report
  • [Presentation] Self-assembling stereocomplex nanoparticles by enantiomeric poly(γ-glutamic acid)-poly(lactide) graft copolymers as a protein delivery carrier2013

    • Author(s)
      Ye Zhu, Takami Akagi, Mitsuru Akashi
    • Organizer
      第62回高分子年次大会
    • Place of Presentation
      京都国際会館
    • Related Report
      2013 Research-status Report
  • [Presentation] ポリ(γ-グルタミン酸)-ポリ乳酸グラフト共重合体のホモ/ヘテロステレオコンプレックス形成を利用した蛋白質/ペプチド担持ナノ粒子の調製2013

    • Author(s)
      朱 葉, 赤木隆美, 明石 満
    • Organizer
      第62回高分子討論会
    • Place of Presentation
      金沢大学角間キャンパス
    • Related Report
      2013 Research-status Report
  • [Presentation] Self-assembling stereocomplex nanoparticles by enantiomeric poly(γ-glutamic acid)-poly(lactide) graft copolymers as a protein delivery carrier2013

    • Author(s)
      Ye Zhu, Takami Akagi, Mitsuru Akashi
    • Organizer
      The 12th US-Japan Symposium on Drug Delivery Systems Conference
    • Place of Presentation
      Lahaina, Maui, Hawaii
    • Related Report
      2013 Research-status Report
  • [Presentation] Stereocomplex formation between enantiomeric poly(gamma-glutamic acid)-poly(lactide) graft copolymers: Characterization and application as protein delivery carriers

    • Author(s)
      朱 葉, 赤木隆美, 明石 満
    • Organizer
      第59回高分子発表会(神戸)
    • Place of Presentation
      兵庫県民会館
    • Related Report
      2013 Research-status Report
  • [Presentation] Self-assembling of peptide-conjugated heterostereocomplex nanoparticles by enantiomeric poly(γ-glutamic acid)-poly(lactide) graft copolymers

    • Author(s)
      朱 葉, 赤木隆美, 明石 満
    • Organizer
      日本バイオマテリアル学会 第8回関西若手研究発表会
    • Place of Presentation
      大阪大学銀杏会館
    • Related Report
      2013 Research-status Report
  • [Book] 進化する医療用バイオベースマテリアル2015

    • Author(s)
      赤木隆美, 明石 満
    • Total Pages
      272
    • Publisher
      シーエムシー出版
    • Related Report
      2014 Annual Research Report
  • [Book] Engineered Cell Manipulation for Biomedical Applications2014

    • Author(s)
      Takami Akagi, Mitsuru Akashi
    • Total Pages
      271
    • Publisher
      Springer
    • Related Report
      2014 Annual Research Report

URL: 

Published: 2014-07-25   Modified: 2019-07-29  

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