Preparation of nano-vaccine for activation of antigen-specific immunity by co-delivery of antigen and cytokine gene
| Project/Area Number |
25750177
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Biomedical engineering/Biomaterial science and engineering
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| Research Institution | Osaka Prefecture University |
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Principal Investigator |
YUBA Eiji 大阪府立大学, 工学(系)研究科(研究院), 助教 (80582296)
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| Project Period (FY) |
2013-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2014: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2013: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
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| Keywords | pH応答性高分子 / リポソーム / サイトカイン / 樹状細胞 / 遺伝子 / 細胞質デリバリー / 細胞傷害性T細胞 / ナノワクチン / 膜融合 / 細胞障害性T細胞 |
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| Outline of Final Research Achievements |
In this study, we developed co-delivery system of cytokine-encoding gene and antigen using cytokine-encoding gene-cationic lipid complexes and antigen-loaded liposomes modified with fusogenic polymers. This co-delivery systems achieved complete cure of tumor-bearing mice by antigen-specific antitumor immunity induced by synergetic effect of cytoplasmic delivery of antigen and introduction of cytokine gene, which induce antigen-specific cellular immunity and activates cellular immunity, respectively. Therefore, such fusogenic polymer-based co-delivery system of cytokine gene and antigen are promising as antigen delivery systems for cancer immunotherapy.
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Report
(3 results)
Research Products
(67 results)
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[Journal Article] Effective enhancement of anti-tumor immune responses by transfection of IFNγ gene into tumor using a new type synthetic vector.2014
Author(s)
Wijesekera, D.P.H., Sugiura, K., Yuba, E., Ueda, K., Wijewardana, V., Kanegi, R., Nishimura, T., Ushigusa, T., Hatoya, S., Kono, K., Inaba, T.
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Journal Title
Vet. Immunol. Immunopathol.
Volume: 162
Issue: 1-2
Pages: 59-64
DOI
Related Report
Peer Reviewed / Acknowledgement Compliant
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