Fabrication of Fragmented Nanosheets with Patchwork-adhesion Behavior and Their Biomedical Applications
| Project/Area Number |
25750178
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Biomedical engineering/Biomaterial science and engineering
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| Research Institution | Tokai University |
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Principal Investigator |
OKAMURA Yosuke 東海大学, 創造科学技術研究機構, 講師 (40365408)
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| Research Collaborator |
INAGAKI Yutaka 東海大学, 医学部, 教授 (80193548)
SUMIYOSHI Hideaki 東海大学, 医学部, 講師 (60343357)
TAKANO Shuta
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| Project Period (FY) |
2013-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2014: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2013: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Keywords | ナノ材料 / 超薄膜 / 生体材料 / 高分子超薄膜 |
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| Outline of Final Research Achievements |
We have proposed biodegradable ultra-thin films, so-called nanosheets. These nanosheets represent unique properties such as high flexibility and good adhesiveness. However, they are often hard to wrap irregular/uneven interfaces due to the structural aspect (cm-size). In this study, we proposeed a fragmentation method of the nanosheets composed of poly(L-lactic acid) (PLLA) and a patchwork coating against various interfaces.
The PLLA nanosheets could be easily fragmented by homogenization and then reconstructed into a sheet on various interfaces without any adhesive reagents. We refer to this reconstruction as a “patchwork” technique. For a biomedical application, we demonstrated that the patchwork of fragmented nanosheets act as an anti-tissue adhesion materials.
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Report
(3 results)
Research Products
(9 results)
