Development of non-invasive blood oxygen saturation mapping system based on photoacoustic technology

• Project/Area Number: 25750192
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Medical systems
• Research Institution: National Defense Medical College
• Principal Investigator: HIRASAWA Takeshi 防衛医科大学校(医学教育部医学科進学課程及び専門課程、動物実験施設、共同利用研究, 医学教育部医学科専門課程, 助教 (60583086)
• Project Period (FY): 2013-04-01 – 2016-03-31
• Project Status: Completed (Fiscal Year 2015)
• Budget Amount: ¥3,510,000 (Direct Cost: ¥2,700,000、Indirect Cost: ¥810,000); Fiscal Year 2015: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000); Fiscal Year 2014: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2013: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
• Keywords: 光音響画像化技術 / 光音響イメージング / 超音波 / レーザー / 血液酸素飽和度 / オキシメトリ / ウェーブレット変換 / マルチスペクトルイメージング / 光音響 / マルチスペクトル / 光音響画像 / 機能イメージング / 光学特性 / 周波数解析 / 光超音波

Outline of Final Research Achievements

Photoacoustic imaging is a medical imaging technology that offers high contrast images of blood vessels in biological tissue.　Photoacoustic imaging system consists of an ultrasound imaging device and a pulsed light source. The purpose of this research was to develop a method to measure blood oxygen saturation of blood vessels in biological tissues non-invasively and continuously. A photoacoustic signal analysis method to measure blood oxygen saturation accurately was proposed. Furthermore, an imaging system to offer blood oxygen saturation mapping was developed.

Research Products

• [Journal Article] Photoacoustic imaging of small organic molecule-based photoacoustic probe in subcutaneous tumor using P(VDF-TrFE) acoustic sensor (2015)
  • Author(s): Takeshi Hirasawa,Shinpei Okawa,Mako Kamiya,Yasuteru Urano,Miya Ishihara
  • Journal Title: Proceedings of SPIE Volume: 9323 Pages: 93233C-93233C
  • DOI: 10.1117/12.2081223
  • Peer Reviewed
• [Journal Article] Quantification of optical attenuation coefficient based on continuous wavelet transform of photoacoustic signals measured by a focused broadband acoustic sensor (2014)
  • Author(s): Hirasawa T, Okawa S, Fujita M, Kushibiki T, Ishihara M.
  • Journal Title: Proceedings of SPIE Volume: 8943 Pages: 89435Z-89435Z
  • DOI: 10.1117/12.2041676
  • Peer Reviewed
• [Journal Article] Quantification of effective attenuation coefficients using continuous wavelet transform of photoacoustic signals (2013)
  • Author(s): Hirasawa T, Fujita M, Okawa S, Kushibiki T, Ishihara M.
  • Journal Title: Applied Optics Volume: 52(35) Issue: 35 Pages: 8562-8571
  • DOI: 10.1364/ao.52.008562
  • Peer Reviewed
• [Presentation] Effect of reference spectra in spectral fitting to discriminate enzymeactivatable photoacoustic probe from intrinsic optical absorbers (2016)
  • Author(s): Takeshi Hirasawa, Shinpei Okawa, Ryu J Iwatate, Mako Kamiya, Yasuteru Urano, Miya Ishihara
  • Organizer: SPIE Photonics West BiOS 2016
  • Place of Presentation: サンフランシスコ
  • Year and Date: 2016-02-14
  • Int'l Joint Research
• [Presentation] Photoacoustic imaging of small organic molecule-based photoacoustic probe in subcutaneous tumor using P(VDF-TrFE) acoustic sensor (2015)
  • Author(s): Takeshi Hirasawa, Shinpei Okawa, Mako Kamiya, Yasuteru Urano, Miya Ishihara
  • Organizer: SPIE Photonics West Biomedical Optics, BiOS 2015
  • Place of Presentation: The Moscone Center (San Francisco, California, USA)
  • Year and Date: 2015-02-09
• [Presentation] Quantification of optical attenuation coefficient based on continuous wavelet transform of photoacoustic signals measured by a focused broadband acoustic sensor (2014)
  • Author(s): Takeshi Hirasawa, Shinpei Okawa, Masanori Fujita, Toshihiro Kushibiki, Miya Ishihara
  • Organizer: SPIE Photonics West Biomedical Optics, BiOS 2014
  • Place of Presentation: The Moscone Center (San Francisco, California USA)